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Henry Gray (1825–1861).  Anatomy of the Human Body.  1918.
 
closed amnion. It possessed a minute yolk-sac and was surrounded by mesoderm, which was connected by a band to that lining the trophoblast (Fig. 32). 1


FIG. 58– Human embryo about fifteen days old. (His.) (See enlarged image)


Second Week.—By the end of this week the ovum has increased considerably in size, and the majority of its villi are vascularized. The embryo has assumed a definite form, and its cephalic and caudal extremities are easily distinguished. The neural folds are partly united. The embryo is more completely separated from the yolk-sac, and the paraxial mesoderm is being divided into the primitive segments (Fig. 58).


FIG. 59– Human embryo between eighteen and twenty-one days old. (His. (See enlarged image)


Third Week.—By the end of the third week the embryo is strongly curved, and the primitive segments number about thirty. The primary divisions of the brain are visible, and the optic and auditory vesicles are formed. Four branchial grooves are present: the stomodeum is well-marked, and the bucco-pharyngeal membrane has disappeared. The rudiments of the limbs are seen as short buds, and the Wolffian bodies are visible (Fig. 59).


FIG. 60– Human embryo, twenty-seven to thirty days old. (His.) (See enlarged image)

Note 1.  Bryce and Teacher (Early Development and Imbedding of the Human Ovum, 1908) have described an ovum which they regard as thirteen to fourteen days old. In it the two vesicles, the amnion and yolk-sac, were present, but there was no trace of a layer of embryonic ectoderm. They are of opinion that the age of Peters’ ovum has been understated, and estimate it as between thirteen and one-half and fourteen and one-half days. [back]

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