Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the largest reduction in imatinib binding? Phe317 ☆ Tyr253 A. Phe317-Tyr B. Tyr253 Phe C. Thr315-lle D. lle313-Leu E. Phe359-Tyr Thr315 Phe382 Ile313 Met290 Glu286 Asp381 His361 Phe359
Q: How do you think evidence from nursing journals affects patient care.
A: Nursing journals are periodical publications that focus on disseminating information related to…
Q: Is the C-section rate is currently lowering to near what it was in 1970?
A: A Cesarean section is a surgical method of delivering a baby. It occurs when giving birth naturally…
Q: The term ABUSE as it relates to elderly people can include: (select all that apply): stealing money…
A: Elderly abuse is the intentional negligence that causes harm to an elderly person over 60 years of…
Q: Visualise yourself in the role of a second year BN (Bachelor of Nursing) student on the last week of…
A: Acutе Bactеrial Mеningitis is a sеvеrе and potеntially lifе-thrеatеning infеction charactеrizеd by…
Q: A patient is transported to the emergency department following a motorcycle accident. After a CT…
A: Motor speech disorders are impairments in the systems and mechanisms that control the movements…
Q: Explain the stages of Bronchopulmonary Dysplasia?
A: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that primarily affects premature infants,…
Q: Discuss alternative treatments that could be effective in treating pain.
A: Alternative treatments for pain focus on approaches beyond traditional medications or surgical…
Q: Mr. Ali, a 78-year-old devout Muslim man, requires assistance with showering today. He is…
A: Mr. Ali, a 78-year old devout Muslim manrequires assistance with showering todayHe is specifically…
Q: How to restate the principles of medication administration? What is the principles of medication…
A: Restating the principles of medication administration is expressing the fundamental concepts in a…
Q: what is the important of pharmacology in a nurses career?
A: The scientific field that focuses on the investigation of medications and how they interact with…
Q: 1) Alex, a 38-year-old male, visits his primary care physician with complaints of constant tiredness…
A: Alex's first diagnosis, based on test results and symptoms, was probably acute leukemia, more…
Q: Discuss how the nurse can help toprevent deconditioning in the hospitalized patient?
A: A hospitalized patient refers to an individual who is currently admitted to a hospital for medical…
Q: 3. what is the importance of technology literacy in healthcare.
A: Technology literacy in healthcare refers to the ability of healthcare professionals to understand,…
Q: How can I use these research articles to write
A: The pervasive opioid crisis continues to exact a devastating toll on communities, leaving a profound…
Q: Increasing informed patient involvement in their care has which of the following effects? OA.…
A: The question at hand delves into the critical aspect of patient involvement in healthcare…
Q: Explain Sudden Infant Death Syndrome & its risk factors?
A: Sudden Infant Death Syndrome (SIDS) is the sudden, unexplained death of an otherwise healthy infant,…
Q: Explain why palliative patients are more likely to have 'Psychological distress and depression'.
A: Palliativе patiеnts, oftеn rеfеrrеd to as individuals in palliativе carе, arе thosе facing advancеd,…
Q: why you should not apply CPAP to a patient in respiratory arrest.
A: Respiratory arrest is a medical emergency that occurs when a person's breathing stops. It is a…
Q: You are delivering a food tray to one of your residents in their room. Upon arriving you discover…
A: The objective of this question is to understand the appropriate action a nursing assistant should…
Q: What is the access to health care in India and what are the morbidity and mortality rates
A: The mortality rate is the number of deaths in a particular population during a specific period of…
Q: what are Nursing care for patient after insertion of pacemaker?*
A: A pacеmakеr is a tiny, surgically implantеd mеdical dеvicе that produces еlеctrical impulsеs to…
Q: Where would this condition of hypertension be mentioned in the record.
A: Hypertension, commonly known as high blood pressure, is a medical condition characterized by the…
Q: What was unusual about the final congressional vote on the Medicare Modernization Act.
A: The Medicare Modernization Act, also known as the MMA, is a United States federal law that was…
Q: Surgical Procedure: "Laparoscopic bilateral salphigo oophorectomy" How is it done? Treatment of…
A: Bilateral salpingo - oophorectomy is a surgical procedure, through which, both fellopian tubes…
Q: Should Jhon expect any variation to the normal values of the heart rate knowing that the patient in…
A: Flight or fight mechanism is our body's automatic mechanism which prepares our body to accept or…
Q: Glucose is the primary energy source for both anaerobic and aerobic metabolism. True False
A: Glucose is a relatively simple sugar (monosacharide) that is the mainly the source of energy for the…
Q: Discuss 2 notable case studies of specific health care institutions in the US that extensively…
A: Case study is the detailed examination or analysis of a particular example which showcases how a…
Q: What are the Nursing Responsibilty of Scrub Nurse and Circulating Nurse in the given surgical…
A: In the intricate realm of surgical procedures, the roles of the scrub nurse and circulating nurse…
Q: Analyze and summarize causes and issues of suicide in women in China
A: Suicide is a very serious public issue that usually impacts many millions of individuals globally…
Q: What evidence supports the use of psychedelic drugs as a medical therapy and conditions might such…
A: Psychedelic drugs are a class of drugs that induce altered perceptions, thoughts, and feelings.…
Q: An SLP is working with a patient who has flaccid dysarthria. After many weeks of therapy, the SLP…
A: Flaccid dysarthria is a motor speech disorder often resulting from damage to the lower motor neurons…
Q: Compare and contrast global nutritional deficiencies, such as iron-deficiency anemia, niacin,…
A: Iron is a mineral needed for various bodily functions specially for the production of hemoglobin in…
Q: What are the small dark blue dots in this slide? Osecretory vessicles in a presynaptic neuron…
A: Answer - cerebellum.The cerebellum is a major component of the human brain, because it plays a major…
Q: why COPD patient initially treated by nebulizer in hospital ?
A: Patients with Chronic Obstructive Pulmonary Disease (COPD) are often initially treated with a…
Q: 6. How would you navigate a situation where a competent patient refuses a life-saving treatment?
A: A life-saving treatment refers to a medical intervention or therapy that is undertaken with the…
Q: Objective: Care plans will be based on the case studies posted in D2L (go to the Chronic illness…
A: Chronic illness management is a complex and critical aspect of nursing care. Primarily when patients…
Q: Mrs Romano has been transferred to the surgical ward from PACU. (Appendix 1 ISBAR handover PACU) 2.…
A: Post-operative recovery monitoring is a crucial component of perioperative patient management…
Q: A prescription indicates i-iii tsp po q 4-6 hr prn. How many ounces are needed for a five-day…
A: Prescribing medication is a task that should be done by a qualified healthcare professional who can…
Q: A child who weighs 25 kg is prescribed gentamicin 40 mg IVPB twice per day over 20 minutes. The…
A: To calculate the rate of administration in mL/hr, you can use the following formula:Rate (mL/hr) =…
Q: how does loxapine medication affect thermoregulation?
A: Loxapine is an antipsychotic medication used primarily in the treatment of schizophrenia. It works…
Q: 4. Explain the drug-nutrient interaction between methotrexate, leucovorin, and folate?
A: The term "drug-nutrient" refers to the interactions between drugs (medications) and nutrients…
Q: A blood specimen from a healthy individual that is being sent by aircraft from your laboratory to a…
A: According to the World Health Organization (WHO), the transport of infectious substances is…
Q: Order: 5 mcg/kg/minute IV Patient: 220 lb Supply 1g/250 mL D5W
A: 1)GivenOrder:5mcg/kg/minWeight : 220 lbs (to convert to kilograms divide pounds by 2.2…
Q: What is a safe dose of IV Cefazolin for a pediatric patient.
A: Cefazolin is a cephalosporin antibiotic. It is used in the treatment of certain conditions such as…
Q: Define medication for Alzheimer?
A: Alzheimer's disease is a progressive and degenerative brain disorder that primarily affects memory,…
Q: If I have a higher concentration of water inside my cells , which is low concentration of solute…
A: In a hypotonic solution there is a higher concentration of water outside the cell compared to the…
Q: Provide a comprehensive description of Palliative care nurses.Explain how nurses undertaking this…
A: Hеalth promotion is a multifacеtеd approach to еnhancing ovеrall wеll-bеing and prеvеnting illnеss…
Q: Which of the following is a preventive service covered by Medicare at no cost to beneficiaries? A.…
A: Medicare is a, government aided national health insurance program, in the United States.It started…
Q: Decriminalizing drugs (e.g., heroin) in Portugal led to an increase in drug use and overdose deaths.…
A: Decriminalizing drugs refers to the process of eliminating or reducing the criminal penalties…
Q: You are the SLP in an outpatient clinic working with a patient with a recently diagnosed bulbar…
A: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder which affects the motor neurons,…
Trending now
This is a popular solution!
Step by step
Solved in 4 steps
- An individual carries a somatic mutation that changes a lysinecodon into a glutamic acid codon. Prior to acquiring this mutation,the individual had been exposed to UV light, proflavin, and5-bromouracil. Which of these three agents would be the mostlikely to have caused this somatic mutation? Explain your answer.According to the research article: “Telomerase Modulates Wnt Signalling by Association with Target Gene Chromatin,” how did the authors determine that TERT, Brg1, and beta catenin were all part of the same protein complex on TCF sites in vivo? Describe the assay used to determine this.The codon change (Gly-12 to Val-12) in human rasH that convertsit to oncogenic rasH has been associated with many types ofcancers. For this reason, researchers would like to develop drugs toinhibit oncogenic rasH. Based on your understanding of the Rasprotein, what types of drugs might you develop? In other words,what would be the structure of the drugs, and how would theyinhibit Ras protein? How would you test the efficacy of the drugs?What might be some side effects?
- . An interesting mutation in lacI results in repressorswith 110-fold increased binding to both operator andnonoperator DNA. These repressors display a “reverse”induction curve, allowing β-galactosidase synthesis inthe absence of an inducer (IPTG) but partly repressingβ-galactosidase expression in the presence of IPTG. Howcan you explain this? (Note that, when IPTG binds a repressor, it does not completely destroy operator affinity,but rather it reduces affinity 110-fold. Additionally, ascells divide and new operators are generated by thesynthesis of daughter strands, the repressor must findthe new operators by searching along the DNA, rapidlybinding to nonoperator sequences and dissociating fromthem.)Predict and explain the effect on GAL1 transcription, in the presence of galactose alone, of the following mutations:a. Deletion of one Gal4-binding site in the GAL1 UAS element.b. Deletion of all four Gal4-binding sites in the GAL1 UAS element.c. Deletion of the Mig1-binding site upstream of GAL1.d. Deletion of the Gal4 activation domain.e. Deletion of the GAL80 gene.f. Deletion of the GAL1 promoter.g. Deletion of the GAL3 gene.Arginine is one of the amino acids that serves as a building block for protein synthesis. Arginine biosynthesis depends on the expression of the arg operon, which encodes ArgC (a reductase) and ArgB (acetylglutamate kinase). Which of the following statements regarding mutation of the arginine biosynthesis repressor ArgR is true? O A 1-bp insertion in the argR gene would result in a mutant able to grow in the absence of arginine, O A 1-bp deletion in the argB gene would result in a mutant unable to transcriptionally regulate the arg operon encoding argB. O A 1bp insertion in the argC gene would result in a mutant able to grow in the absence of arginine. O A 1-bp deletion in the argR gene would result in a mutant that represses the arg operon when grown in the presence of arginine. None of the above.
- If the following truncated peptide represents the active domain of the COVID19’s S-protein N-terminal ----Leu-Leu-Gly-Cys-Ile-Glu-Ser-Thr-Cys-Ala ------ C-terminal a) state the RNA sequence of this peptide given that Leu is the first amino acid b) show a point mutation using the RNA sequence & explain how it results in silent mutation effect c) show a deletion mutation using the RNA sequence & explain the consequence(s)Would the following alterations to Src be oncogenic? Explain. (a) The deletion or inactivation of the SH3 domain. (b) The mutation of Tyr 416 to Phe.Propose a mutation for Uniprotkb-P39086 and it’s effect
- Consider the now dominant variant of the SARS-CoV-2 called the D614G mutation: a) The mutation changes an Aspartate (D, Asp) to a Glycine (G, Gly) at nucleotide position 614 (that’s why it’s called the D614G mutant) in the S1 subunit of the Spike protein. Using only the information above and a codon table, what are the mRNA codon sequences of the 2019-dominant and 2020-dominant Spike proteins? Note the figure above is not needed toanswer the question. Report in 5’ to 3' orientation __________________________________________ b) What type of substitution is this? In your answer, address the following: • The expected substitution in base sequence (e.g., A à C)• If the mutation is synonymous, nonsynonymous, or a frameshift• If the mutation is a transition or a transversion c) The mutation increases infectivity by reducing the stability of the Spike protein such that it can remain in the open conformation more often. The open conformation increases the chances of binding to the host ACE2…Which of the following mutations would produce a form of the Ras protein that would be more difficult to inactivate than normal Ras? Briefly explain your reasoning.(i) A mutation that allows Ras to cleave (hydrolyze) GTP more rapidly than usual(ii) A mutation that causes Ras to bind Ras-GAP more tightly than usual(iii) A mutation that causes Ras to cleave (hydrolyze) GTP more slowly than usualIn the galactose operon of E. coli, a repressor, encoded by the galR gene, binds to an operator site,galo, to regulate the expression of three structuralgenes, galE, galT, and galK. Expression is inducedby the presence of galactose in the media. For eachof the strains listed, would the cell show constitutive, inducible, or no expression of each of the structural genes? (Assume that galR− is a loss-of-functionmutation.)a. galR−galo+galE+galT+galK+b. galR+galocgalE+galT+galK+ c. galR−galo+galE+galT+galK−/galR+galo+galE−galT+galK+d. galR−galocgalE+galT+galK−/galR+galo+galE−galT+galK+