Human genetics lab complete

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University of North Carolina, Charlotte *

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3111

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Biology

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Apr 3, 2024

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pdf

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3

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ANSWER SHEET FOR GENETICS LAB #4 – Human Gene9cs NAME: Damarae Thomas Lab Sec4on: L01 Pedigree Analysis Mode of Inheritance = Y Linked I ___XYA_____ _XX __XX_____. __XYA______ 1 2 3 4 II ___XX_____ __XYA___ __XX__ ___XYA__ ___XYA_ ___XX_____ 1 2 3 4 5 6 __XYa______ 7 III __XYa__ ___XX___ __XYA__ _XYA___ __XYA__ _XX__ 1 2 3 4 5 6 __XYA____ _XYA___ _XX__ _. ___XYa____ __XX______ 7 8 9 10 11 IV __XYa__ _XYA_______ __XX______ __XX______ ___XX_____ 1 2 3 4 5 Answer Sheet Questions 1. Identify which mode(s) of inheritance can be eliminated, and indicate why this/these individual(s) are inconsistent with that mode of inheritance. Since the trait is only expressed and transmitted in males we can rule out autosomal and recessive since we can see that this disease is sex-linked. We also see that only males are diseased and we can rule out it being x-linked because if it was maybe women would have it as well. We can conclude that the disease is sex-linked dominant because every male who is affected has the disease and it only occurs in males
2. Explain how you were able to determine that a trait shown on a pedigree was sex-linked/ autosomal, dominant/recessive. I was able to determine that it was sex-linked because only one gender was affected. We know that y-linked diseases will be passed to males 100 percent of the time because males only have the y chromosome 3. Answer the question posed in the pedigree below assuming individual II-1: (a) is a carrier and (b) is not a carrier. Show your calculations. a) is a carrier If the father is a carrier and the mother is also a carrier because of her parents then the child has a 25 percent chance of carrying the disease. If the mother receives homozygous dominant traits from her parents then the child would not get the disease b) is not a carrier If the father is not a carrier and he has homozygous dominant then it would not maIer is the mother is a carrier or not, the child would not be at risk of geLng this disease. If the mother is AA then the child will be AA, if the mother is a carrier for the disease then the child has a 50 percent chance of being Aa which means the child will be a carrier but not affected since this is a recessive disease. Karyotypes Karyotype #1 designation = Trisomy 21 47 XX Insertion Genetic condition: Down syndrome
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