BIOB11 Part 2_ Topic Research and Timeline - FINAL PRODUCT
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BIOB11 -
Group # 10
Names of
contributing
group members:
Avika, Ishraq, Piraveen, Sadaf, Sitha, Tanisha
Topic chosen: Type 2 Diabetes
A) Timeline:
B) Article 1: Pathophysiology of Type 2 Diabetes Mellitus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503727/
Introduction:
●
The article discusses the pathophysiology of Type 2 Diabetes Mellitus (T2DM) and its
underlying causes.
●
It emphasizes the importance of insulin secretion by pancreatic β-cells and the
responsiveness of insulin-sensitive tissues in glucose homeostasis.
Molecular Mechanisms of T2DM:
●
The review focuses on the molecular mechanisms and pathways involved in insulin
metabolism leading to T2DM and insulin resistance.
●
It covers insulin synthesis, release, sensing, and their downstream effects on
insulin-sensitive organs.
Pathological Factors:
●
The article addresses the role of nutritional factors, physical activity, gut dysbiosis, and
metabolic memory in perpetuating T2DM.
●
It highlights the association of T2DM with accelerated atherosclerosis development.
Cardiovascular Risk and T2DM:
●
The review examines the molecular mechanisms linking T2DM and insulin resistance
with cardiovascular risk, a significant complication of T2DM.
●
It emphasizes the importance of understanding these mechanisms for managing and
preventing cardiovascular complications in T2DM.
Conclusion:
●
The article provides a comprehensive overview of T2DM, shedding light on its molecular
mechanisms, associated pathological factors, and cardiovascular risk.
●
It underscores the significance of addressing insulin metabolism and its regulation for
understanding and managing T2DM effectively.
●
This article is very reliable and scores a 5/5 for accuracy and broad applicability. This is
because the topic of diabetes is very old and a lot of research has been undertaken to
better understand it, the ideas presented in this study are peer-reviewed and accepted as
fact by the scientific community.
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