BIOB11 Part 2_ Topic Research and Timeline - FINAL PRODUCT

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Apr 3, 2024

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BIOB11 - Group # 10 Names of contributing group members: Avika, Ishraq, Piraveen, Sadaf, Sitha, Tanisha Topic chosen: Type 2 Diabetes A) Timeline:
B) Article 1: Pathophysiology of Type 2 Diabetes Mellitus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503727/ Introduction: The article discusses the pathophysiology of Type 2 Diabetes Mellitus (T2DM) and its underlying causes. It emphasizes the importance of insulin secretion by pancreatic β-cells and the responsiveness of insulin-sensitive tissues in glucose homeostasis. Molecular Mechanisms of T2DM: The review focuses on the molecular mechanisms and pathways involved in insulin metabolism leading to T2DM and insulin resistance. It covers insulin synthesis, release, sensing, and their downstream effects on insulin-sensitive organs. Pathological Factors: The article addresses the role of nutritional factors, physical activity, gut dysbiosis, and metabolic memory in perpetuating T2DM. It highlights the association of T2DM with accelerated atherosclerosis development. Cardiovascular Risk and T2DM: The review examines the molecular mechanisms linking T2DM and insulin resistance with cardiovascular risk, a significant complication of T2DM. It emphasizes the importance of understanding these mechanisms for managing and preventing cardiovascular complications in T2DM. Conclusion: The article provides a comprehensive overview of T2DM, shedding light on its molecular mechanisms, associated pathological factors, and cardiovascular risk. It underscores the significance of addressing insulin metabolism and its regulation for understanding and managing T2DM effectively. This article is very reliable and scores a 5/5 for accuracy and broad applicability. This is because the topic of diabetes is very old and a lot of research has been undertaken to better understand it, the ideas presented in this study are peer-reviewed and accepted as fact by the scientific community.
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