Module 8 Worksheet

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Keck Graduate Institute *

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Biology

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Jan 9, 2024

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docx

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Uploaded by MaryB01

Answer the following multiple-choice questions. There is no time limit, and you may save and return to your work as many times as you need to before submitting the worksheet. But you may submit this worksheet only once. Flag question: Question 1 Question 1 1 pts What is the lifetime risk for women dying of cancer? Group of answer choices 23% 59% 43% 19% Flag question: Question 2 Question 2 1 pts Select the appropriate letter regarding tumor marker tests: 1. Screen for cancer 2. Aid in staging of cancer 3. Monitor response to therapy 4. Detect recurrent disease Group of answer choices 1, 2, and 3 1, 2, and 4 2, 3, and 4 All four are appropriate. 4 Flag question: Question 3 Question 3 1 pts Tumor markers may be defined as Group of answer choices None of these Analytic tests (e.g., immunoassays) used to mark cancer cells Radioactive substances and chemicals used to help the physician identify cancer cells Biologic substances synthesized and released by cancer cells or substances produced by the host in response to cancer cells

Flag question: Question 4 Question 4 1 pts Which of the following is an oncofetal antigen? Group of answer choices CA-125 PSA AFP β -hCG Flag question: Question 5 Question 5 1 pts What are the major limitations of tumor markers? Group of answer choices Cost Sensitivity and specificity Imprecision Turnaround time Flag question: Question 6 Question 6 1 pts The major clinical use for CA 15-3 is monitoring treatment response of Group of answer choices Colorectal cancer Ovarian carcinoma Prostatic cancer Breast cancer Flag question: Question 7 Question 7 1 pts The most common immunoassays used to measure PSA detect which form of the enzyme? Group of answer choices PSA complexed with α 1-antichymotrypisin PSA complexed with α 2-macroglobulin Total PSA Free PSA

Flag question: Question 8 Question 8 1 pts Which of the following enzymes is commonly used as a tumor marker? Group of answer choices Lipase ALT PSA DNA Polymerase Flag question: Question 9 Question 9 1 pts A tumor marker used in the assessment of choriocarcinoma or hydatidiform mole is Group of answer choices β -HCG CEA AFP IgG Flag question: Question 10 Question 10 1 pts A serum PSA is used for all of the following except Group of answer choices Detecting recurrence Screening Diagnosis Monitoring response Flag question: Question 11

Question 11 1 pts The following serum PSA measurements were obtained from two male patients who were being monitored over an 18-week period. Week 1 Week 6 Week 10 Week 15 Week 18 Patient A 21 ng/mL 26 ng/mL 46 ng/mL 79 ng/mL 78 ng/mL Patient B 14 ng/mL 46 ng/mL 89 ng/mL 120 ng/mL 110 ng/mL Which of the following statements most accurately describes these data? Group of answer choices Patient A may have a more aggressive prostate cancer based on the velocity of these measurements. Patient A is most likely to have benign prostate cancer. Patient B is most likely to be experiencing an inflammatory reaction, and this is largely contributing to the elevated PSA above 100 ng/mL. Patient B may have a more aggressive prostate cancer based on the velocity of these measurements. Flag question: Question 12 Question 12 1 pts When measuring tumor markers in the clinical laboratory, which of the following has been reported to contribute to 30% to 70% of the total amount of error? Group of answer choices Preanalytical errors Not comparing lot numbers between ELISA kits Analytical errors Using different immunoassay methods Hook effect Flag question: Question 13

Question 13 1 pts Which of the following methods is commonly used to measure endocrine metabolites? Group of answer choices HPLC Protein electrophoresis Gas chromatography Immunoassays Electrochemistry Flag question: Question 14 Question 14 1 pts Which of the following describes the correct source, function, and deficient state of the vitamin listed? Group of answer choices Folic acid — dairy products, myelin formation Niacin — meat, oxidation–reduction reactions, scurvy Vitamin E — plant tissues, antioxidant, osteomalacia Thiamine (B 1 ) — whole grains, carbohydrate metabolism, beriberi Flag question: Question 15 Question 15 1 pts Which vitamin would be affected if a patient was diagnosed with a disorder involving fat absorption? Group of answer choices Thiamine Ascorbic acid Vitamin B 12 Vitamin K Flag question: Question 16 Question 16 1 pts Which vitamin is a powerful antioxidant, protects the erythrocyte membrane from oxidative stress, and is found primarily in vegetable oils? Group of answer choices Vitamin C Vitamin K Folic acid Vitamin E

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