Challenges-Exam 1 2021
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Exam 1 Challenges, PHAR 4200
1.
Which of the following is the correct sequence of events leading to an increase in
IL-2 gene transcription?
Concern: One student believes that this concept was covered by Dr. Salim in our FIMMRA course but not our Immunology course. It would appear unfair to test students on a concept not covered in this course.
From Dr. Salim: The topic on which this question was based-on was covered in sufficient details in the immunology course. I also had posted study guidance to assist with this part (in the form of handwritten schemes), so I am sorry I am unable to accept the challenge.
2.
Which of the following is an important anatomical barrier to infection by microorganisms?
A. α- and β- defensins
B. Mucous membranes
C. Lysozyme and sweat
D. Commensal bacteria
Choices ‘C’ and ‘D’ will be accepted
3.
Cytotoxic T cells isolated from an individual named Cliff can kill virus-infected fibroblasts isolated from
A. Cliff himself and any other person.
B. Cliff himself and his father.
C. any member of Cliff’s ethnic group.
D. none of Cliff’s biologic siblings.
Cliff’s CTLs have been trained to recognize and kill cells from himself, he has MHC genes from both mom and dad, and both sets of genes are expressed (codominance). Cliff’s siblings also have expressed MHC from all of their MHC genes, mom’s and dad’s
Say Cliff’s parents have these haplotypes:
Mom
A/B
Dad
C/D
Each of their children will be one of the following:
A/C
A/D
B/C
B/D
Assume Cliff is B/D. His CTLs can kill any cell with a B or D haplotype, so there is only a 25% chance that one of his siblings will be resistant (the A/C). Due to the question’s wording, 25% of the class chose ‘D’, so that will be accepted, along with ‘B’.
Question with the figure: The way ExamSoft sets up a question like this is convoluted, and I failed it. What was intended was:
A: A few naïve B lymphocytes are being selected
B:
B-lymphocytes are undergoing apoptosis C:
Memory B-lymphocytes are responding
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