Health and promotion assignment 1

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University of Guelph *

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Course

1100

Subject

Chemistry

Date

Oct 30, 2023

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pdf

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3

Uploaded by layanhamarnah11

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Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review Summary (abstract) A Systematic Review study was made on e-cigarettes and its affect on the lungs. E-cigarette is a electrical device (vape) that has liquid substances that can be transformed to smoke by using heat and that its also called Heated Tobacco Products and Electronic Nicotine Delivery Systems. Studies that were included were published between January 2013 and August 2020. It was found that smoking is one of the main contributing factors for diseases like cancer, chronic obstructive pulmonary disease asthma, and many more. It was shown that there was a increasing user base targets young people, and these devices are sold without regulation and warnings about their health risks. To describe the adverse effects of these devices on consumers' respiratory systems used an objective systematic review and bibliometric analysis. An analysis of 79 studies was conducted using the PubMed database. These studies aimed to test the effects Electronic Nicotine Delivery Systems and Heated Tobacco Products have on the human respiratory system. Summary results The result of this The majority of reports on ENDS (Electronic Nicotine Delivery Systems) and HTPs (Heated Tobacco Products) are divided into three categories, according to the conceptual structure analysis performed using MCA: in vitro analysis, which includes terms like cell-line and epithelial cells; animal models, which includes terms like mice and lung; and
human studies, which include males, females, and young adults. In vitro models, the cells are either directly exposed to e-liquids in a culture media or to ENDS or HTP vaporisations. Recent studies prefer air-liquid interfaces (ALI) and undiluted aerosols because they both offer a more pertinent approach for toxicological studies related to inhaling ENDS and HTP. Important factors like the cell model used and the method of vaporisation delivery determine the physiological significance of any in vitro study. E-liquids with sweet, fruity, and citrus flavours have a cytotoxic effect and produce more reactive oxygen species (ROS) than those with vanilla or no flavour. Their presence can start pathological processes, oxidative stress, damage to biomolecules (such as DNA and protein alteration), and pro-inflammatory reactions associated with smoking-related diseases. The flavouring in the e-liquids affects endoplasmic reticulum stress, aberrant cell development, and ion calcium (Ca2+) balance, which can lead to chronic inflammation. In vitro exposure to e-cigarette vapour extract enhances platelet-activating factor receptor (PAFR) expression and pneumococcal adhesion and infection cells, whereas inhaling pollutants raises the chance of airway bacterial infection. Matrix metalloproteinase-3 (MMP-3) circulating levels were reduced as a result of repeated inhalations of e-cigarette vapour; decreased levels of this protein may indicate an increased risk of carcinogenesis [26]. Mice exposed to e-cigarette vapour by prolonged inhalation displayed altered intracellular lipid production and increased pulmonary surfactant layer in their alveoli, which led to a downregulation of local macrophages' innate immunity against viral infections [42,63]. Exposure to e-cigarettes in mice resulted in higher mortality, weight loss, and vulnerability to influenza infection. Inflammatory cytokines are upregulated in bronchial epithelial cells according to expression analysis of e-cigarette users, and this is linked to inflammasome. Users of ENDS exhibit decreased endothelial function as well as elevated levels of oxidative stress and
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