Prelab 6

1)  Outline the processes you would adopt to purity and test the purity of sodium benzoate, an active ingredient of most cosmetic products in the laboratory.

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You have a sample of 90 mL cola drink that contains 50 mg of dissolved caffeine. Calculate the total mass of caffeine extracted using 54 mL of dichloromethane in each of the following procedures: the entire volume of dichloromethane is used in one step; the dichloromethane is divided into two (27 mL) portions in a two-step extraction and into three (18 mL) portions in a three-step extraction. Please use two decimal places. Number of extraction steps One Step Two Steps Three Steps Extracted caffeine mass (mg) (Submit)

2) A patient visits your pharmacy with a prescription for 200g Betnovate (betamethasone valerate) 0.1% w/w cream . The specials department has a Betnovate 2.5% w/w cream stock concentration.How much diluent needs to be added to the Betnovate 2.5% w/w cream in grams to produce the Betnovate 0.1% w/w cream for the prescription?State your answer to the nearest whole number.unit- g

C. Fractional Distillation SAMPLES °C at which vapors are collected Distillate Methanol + Ethanol 65 Hexane + Acetone 56 2-propanol + 2-Butanol 82

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Can you answer first 2 questions

You are given a 1:1 (by weight) solid mixture of vitamin C and vitamin A, and you are going to use liquid-liquid extraction to separate one from the other (chemical structures are given below). If you decide to use water (density, 1 g/mL) and ethanol (density, 0.789 g/mL) as your extraction solvents, will this separation be successful? Why or why not? он HO HO. HO HO Vitamin C (ascorbic acid) Vitamin A (retinol)

Look at the diagram below of a ten-fold serial dilution. Serial Dilution 1 mL stock 9 mL stock solution & 9 ml saline 9 mL saline 9 mL saline 9 mL saline 9 mL saline solution solution solution solution solution 1 mL D2 solution to D3 1 mL D3 solution to D4 1 mL D4 solution to D5 1 mL D5 solution to waste D1 D2 D3 D4 D5 D6 In this diagram, D1 is the original solution. For a ten-fold serial dilution, first add 9 mL of solvent (eg. Saline) to 5 new tubes marked D2-D6. Take 1 mL of D1 solution, add to tube D2 and mix. Take 1 mL of D2, add to D3, and mix. Take 1 mL of D3, add to D4, and mix. Take 1 mL of D4, add to D5, and mix. Take 1 mL of D5, add to D6, and mix. Problem 2. If tube D1 has 100% concentration, then what is the % concentration of tube D2? tube D3? tube D4? tube D5?

Q4- AGENERASE oral solution contains 1.5% amprenavir. A pharmacist wished to change the drug concentration to 5 mg/mL by using a diluent of polyethylene glycols. How many milliliters of the oral solution and how many milliliters of the diluent should be used to prepare 8 fluid ounces of the mixture?

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compound A = 0.02 g compound B = 0.012 g If 20 ml of solvent is used, which is the best solvent to use

1) outline the process you would adopt to purity and test the purity of sodium benzoate, an active ingredient of most cosmetic products in the laboratory.

. Given the following drugs in a urine specimen: Cocaine alkaloid Secobarbital (a derivative of barbituric acid) Carisoprodol (a neutral drug)      Devise an analytical flow chart that will be used to separate these substances from a urine specimen. The separation will be liquid extraction methods. Choose appropriate solvents and reagents based on the properties of the materials to be separated.

The mixture contains benzoic acid, 2-napthol, and naphthalene. Dissolve the mixture in the polar solvent ether. When you react the mixture with 10% NaHCO3(sodium bicarbonatea weak base in aqueous solution) reacts with benzoic acid and forms sodium benzoate an ionic compound (similar to NaCl) that dissolves in aqueous solution (heavier than ether in density) and goes to the bottom of the centrifuge tube or to the bottom of the separatory funnel forming two layers. Then remove the bottom aqueous layer and collect in a beaker labeled as bicarbonate extract. Acidify the bicarbonate extract in the beaker to give benzoic acid. The top ethereal layer contains in the centrifuge tube or separatory funnel 2-napthol and naphthalene. To this top layer add 10% NaOH (sodium hydroxideis a strong base in aqueous solution reacts with only 2-napthol, a weak acid forming 2-napthoxide an ionic compound soluble in aqueous solution (similar to NaCl) that goes to the bottom of the centrifuge tube or to…

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flowchart for the Separation of the Components in an Analgesic Tablet

4-bromobenzoic acid (1.0 g)  is dissolved in 20 ml dichloromethane. After addition to a separatory funnel, the dichloromethane solution is treated with 20 ml 3.0 M NaOH solution. After the layers are separated, which layer(s) will contain an organic compound (non-solvent)? What would happen if the aqueous layer is treated with 20 ml 3.0 M HCl?

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Answer #6

Why is the glucose assay one of the most common analytical test performed in clinical chemistry.

NUMBER FOUR PLEASE, not three cause that was answered previously

11. How much fluorouracil powder is in 5% Efudex® cream 50 g? 12. How much oxiconazole nitrate powder is required to prepare the following order? Dr. Barbara Clemmons 121 West Loop Tacoma, WA 00000 phone 555-0404 For Sharon Parker Address R 1% Oxiconazole Nitrate Ointment Disp. 75 g Bater Clear SUBSTITUTION PERMITTED TIMES MeK-3 REFILL 2 Date 1-21 DISPENSE AS WRITTEN DEA No. MO

Question 4 What is the approximate boiling point of the liquid in the mixture with a lower boiling point? Sample Distillation Data 120 100 80 60 40 20 0 0 0.5 00 1 ● 1.5 2 2.5 3 3.5 ● ● 4 4.5

During your first day on the job as a research assistant, you are preparing 50 mL of hybridization solution with the following components and working concentrations: 50% formamide 5X sodium salt citrate 0.5% sodium dodecyl sulfate You start from the following concentrated stock solutions: 100% formamide 20X sodium salt citrate 20% sodium dodecyl sulfate How much of each concentrated stock solution and water will you add?

Given n-hexane (bp 69°C) and cyclohexane (bp 81°C) in a mixture for fractional distillation, which would be expect to be in the receiving flask: All the contents distilled n-hexane cyclohexane 1:2 n-hexane, cyclohexane

beer. A 2.39- mg sample of safrole was dissolved in 103.0 mg of diphenyl ether. The solution had a melting point of 25.70°C. Calculate the molecular weight of safrole. The freezing point of pure diphenyl ether is 26.84°C, and the freezing- point- depression constant, Kf, is 8.00°C/m.

a) Succinimide is an organic compound used in manysyntheses as a building block and is related to a class of drugs known asanticonvulsants. Given the following solubility of succinimide in water andmethanol, which would be a better solvent for recrystallizing succinimide?Solubility data: 1 gram of succinimide is soluble in 5 mL of cold water, 3 mL ofwater at room temperature and 0.7 mL of boiling water. 1 gram of succinimide issoluble in 30 mL of cold methanol, 24 mL of room temperature methanol and 5mL of hot methanol. Show calculations.b) A researcher wanted to purify 0.4 grams of crude succinimide viarecrystallization using only 2 mL of solvent. Decide the best solvent to use (water or methanol) to show the maximum % recovery of the researcher. The best solvent chosen here, may differ from the one chosen in part a. PLEASE show calculations for both parts as proof.

Which of the following compounds has a different classification according to their solubility? ac NH₂ НО. HS OH OH OH NH₂ F

During the distillation of the Bromobenzene and water mixture which fraction is richer in Bromobenzene:   a) First fraction   b) Second fraction   c) The last fraction   d) All fractions have the same composition

You have a prescription for 150g of 2% psoriasis w/w cream but only 8% cream in stock. How much of this more concentrated cream is required to make this prescription?

3. What is the major obstacle that fractional distillation overcomes? 1 1° in422 male distillatio