Exam 4 Fall 2021

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Kennesaw State University *

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3500

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Chemistry

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Dec 6, 2023

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Biochemistry CHEM 3500 Fall 2021 Exam 4 Name: ______________________________ Dr. Meades 33 possible points For questions 1-32, choose the one best answer (1 point each). Bold words are clues. 1.) Which lists the equivalent functional component or space in chloroplasts and mitochondria? A) chloroplastic outer membrane = mitochondrial inner membrane B) stroma = cristae C) thylakoid = matrix D) chloroplastic inner membrane = mitochondrial outer membrane E) thylakoid membrane = cell membrane 2.) What product of triacylglycerol digestion requires phosphorylation to eventually enter glycolysis? A) malonyl-CoA B) pyruvate C) glycerol D) sphingosine E) cholesterol F) fatty acid G) C & F 3.) One of the starting materials of photosynthesis is _____. A) glucose B) H 2 O C) NADPH D) NADH E) O 2 F) ATP G) UTP 4.) The enzyme in the reaction depicted is part of the anabolic pathway that synthesizes _____. A) fatty acids B) cholesterol C) purines D) pyrimidines E) It is instead part of a catabolic pathway. 5.) What class is the enzyme in the reaction depicted? A) hydrolase B) isomerase C) lyase D) transferase E) ligase F) oxidoreductase 6.) The “ X ” in the reaction depicted is _____. A) Co-Q B) NADH C) CO 2 D) FAD E) FADH 2 F) aspartate 7.) Fatty acid synthesis’ repetitive steps can be abbreviated by which of the following? A) OHIO B) OHIO St. C) MICH D) MICH St. E) CoReDeR F) KSU 8.) The two oxygen atoms in xanthine originate from what source(s) in de novo synthesis? A) glycine and water B) arginine and water C) glutamine and CO 2 D) N 10 -formyl-THF and CO 2 E) 5,10-methylene-THF and water F) CO 2 and water G) There is only one oxygen in xanthine. 9.) During pyrimidine degradation, what are the ultimate fates of the oxygen atoms? A) an amino acid and urea B) ammonia and CO 2 C) UTP and CO 2 D) urea and uric acid 10.) During the flow of electrons from PS II to PS I , which of the carriers must transport them unpaired ? A) cytochrome bf B) plastoquinone C) plastocyanin D) NADPH E) chlorophyll 11.) _____ round(s) of the Calvin cycle are required for the net production of a hexose sugar. A) 1 B) 3 C) 4 D) 6 E) 9 F) 12 G) 18 12.) During the mechanism of ribonucleotide reductase, where does a radical exist? A) 2 C of ribose ʹ B) 3 C of ribose ʹ C) 3 C of deoxyribose ʹ D) a S of cysteine E) all of the above 13.) Partial  oxidation of a 22:0 fatty acid yields which of the following in addition to an (8:0) acyl-CoA ? 14.) Complete  oxidation of a 13:0 fatty acid yields which of the following in addition to propionyl-CoA (3:0) ? 15.) Complete  oxidation of an ω-5, 14:1 fatty acid yields which of the following? A) 7 acetyl CoA + 5 FADH 2 + 6 NADH + 6 H + B) 7 acetyl CoA + 6 FADH 2 + 6 NADH + 5 H + - 1 NADPH C) 5 acetyl CoA + 5 FADH 2 + 5 NADH + 5 H + D) 6 acetyl CoA + 5 FADH 2 + 5 NADH + 5 H + E) 7 acetyl CoA + 6 FADH 2 + 7 NADH + 7 H + F) 7 acetyl CoA + 7 FADH 2 + 7 NADH + 7 H + G) 8 acetyl CoA + 7 FADH 2 + 7 NADH + 7 H + 16.) Which ONE of the following labeled monosaccharides is relocated (on the same molecule) during glycogen degradation ? 17.) Which ONE of the following labeled monosaccharides could be acted upon by the branching enzyme at this point in time? 18.) Which ONE of the following labeled monosaccharides would be removed as glucose by the debranching enzyme ? 19.) Which ONE of the following labeled monosaccharides was added by glycogenin ?

20.) The major metabolite regulating the activity of glycogen phosphorylase is _____ in muscle cells, and _____ in liver cells. A) glucose / ATP B) AMP / ATP C) ATP / glucose D) UTP / AMP E) insulin / Ca 2+ F) UTP / CTP G) insulin / glucagon 21.) Degradation of glycogen found in the liver for use by a distant muscle cell involves which enzyme(s)? (Hint: read that again!) A) phosphofructose isomerase B) glucose-1-phosphorylase C) glycogen synthase D) branching enzyme E) acetyl-CoA carboxylaseF) glucose-6-phosphatase G) B, D, & F 22.) ( Paper 4e2, video 4e3 ) The conveyance of information regulating ribonucleotide reductase substrate specificity involves _____. A) stoichiometric ratios of deoxynucleotides B) hydrogen bonding to amino acids in loop 2 C) deprotonation of a serine in loop 2 D) orientation of an arginine in loop 2 23.) ( Slide 4d#15 ) The PLP-dependent transamination reaction interconverts α-keto acids and α-amino acids. The substrates oxaloacetate and serine would produce which of the following as a product? A) glutamate B) alanine C) asparagine D) hydroxypyruvate E) norvaline F) hydroxyproline 24.) ( Slide 4e#24 ) Binding of _____ in the specificity site of ribonucleotide reductase promotes _____. A) dTTP / the formation of dUDP or dCDP B) dGTP / the formation of dADP C) dCTP / the binding of dATP at the activity site D) dTTP / the binding of ADP at the active site E) dATP / an overall increase in enzyme activity F) ATP / an overall decrease in enzyme activity *25.) ( Slide 4e#24 ) A transposition of the affinities of the substrate specificity site and activity site for ATP would result in _____. A) higher stoichiometric ratios of NTP products B) an overall increase in enzyme activity C) both A & B D) altered stoichiometric ratios of dNDP products E) an overall decrease in enzyme activity F) both D & E 26.) During the Kok cycle of PS II, the cluster of one Ca and four Mn ions has total positive charge of _____ at stage S 2 ? A) 12 B) 14 C) 15 D) 16 E) 17 F) 18 G) 19 27.) In cholesterol synthesis, _____ mevalonate (C 6 ) molecules are used to synthesize each squalene (C 30 ) molecule. A) 2 B) 3 C) 4 D) 5 E) 6 F) 12 G) 18 28.) Concerning the regulation of glycogen metabolism, activation of protein kinase A would have the combined effects of _____ glycogen synthase while _____ glycogen. A) phosphorylating and activating / degrading B) phosphorylating and deactivating / degrading C) dephosphorylating and deactivating / degrading D) dephosphorylating and activating / degrading E) phosphorylating and deactivating / synthesizing F) phosphorylating and activating / synthesizing G) dephosphorylating and deactivating / synthesizing 29.) Complete  oxidation of the fatty acid cis,cis -20:2Δ 14,17 would _____. A) consume one NADPH B) generate one fewer NADH than a saturated 20:0 fatty acid C) produce propionyl-CoA (3:0) D) consume two NADPH E) generate one fewer acetyl-CoA than a saturated 20:0 fatty acid F) consume one FAD + 30.) Effectively, how many protons of the gradient across the thylakoid membrane are depleted when ATP synthase completes one full turn (360°) forming molecule(s) of ATP and relocating it(them) to the cytoplasm? A) 0 B) 3 C) 4 D) 6 E) 9 F) 12 G) 18 31.) What is the name of the enzyme whose mechanism is depicted below? A) methylmalonyl-CoA epimerase B) 3-hydroxyacyl-CoA hydratase C) cis -Δ 3 -enoyl-CoA isomerase D) acyl-CoA dehydrogenase E) 2,4-dienoyl-CoA reductase F) succinyl-CoA synthase G) none of the above 32.) The above enzyme is utilized in the pathway for degrading which of the following starting materials? A) cis -16:1Δ 14 B) trans -18:1Δ 11 C) cis -18:1Δ 11 D) trans -14:1Δ 13 E) 6:0

Biochemistry CHEM 3500 Summer 2021 Exam 4 Name: ______________________________ 33.) (1 point) Mutation of Arg298 of loop 2 to Leu (R298L) would have what effect on ribonucleotide reductase? ( See paper 4e2- fig2&8 and the associated 4e3 video. This is a very short correct answer. Excessive length will not help you. ) Biochemistry CHEM 3500 Summer 2021 Exam 4 Name: ______________________________ 33.) (1 point) Mutation of Arg298 of loop 2 to Leu (R298L) would have what effect on ribonucleotide reductase? ( See paper 4e2- fig2&8 and the associated 4e3 video. This is a very short correct answer. Excessive length will not help you. )

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