BCHM462_Spring2019_Exam 1-1

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Chemistry

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Dec 6, 2023

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BCHM 462-Poulin Metabolism Exam #1 –February 27, 2019 YOUR NAME __________________________ (Last, First, M.I.) STUDENT ID # ________________________ "I pledge on my honor that I have not given or received any unauthorized assistance on this examination (assignment)." I have read the University's Honor Code and will abide by its responsibilities. Signature Page 2 (15 pts.) Page 3 (17 pts.) Page 4 (16 pts.) Page 5 (20 pts.) Page 6 (12 pts.) Page 7 (20 pts.) Total (100 pts.) Initial of last name

Exam 1, BCHM 462 Name: Spring 2019 Page 2 1. For the following question circle the Most correct answer. (15 pts) I. What functional groups are present on this molecule? a. Amino, Amido, Anhydride b. Ether, Hydroxyl and Amido c. Phosphoryl, Imidazole, Amido d. Phosphoanhydride, Amino, Imidazole e. Amino, Hydroxyl, Mixed Anhydride II. Which statement CORRECTLY describes the molecules shown in the figure? a. A and D are enantiomers, and A and C are diastereomers. b. A and D are diastereomers, and B and D are enantiomers. c. A and C are enantiomers, and B and D are diastereomers. d. A and C are diastereomers, and B and D are enantiomers. e. All are diastereomers to each other. III. 1,3-Bisphosphoglycerate can be hydrolyzed into 3-phosphoglycerate and inorganic phosphate (Pi) with a Δ G °’ of –49.3 kJ/mol. If ATP can be hydrolyzed into ADP + Pi with a Δ G °’ of –30.5 kJ/mol, what is the free energy change for the reaction of: 3-phosphoglycerate + ATP → 1,3-bisphosphoglycerate + ADP a. –79.8 kJ/mol b. –18.8 kJ/mol c. 18.8 kJ/mol d. 79.8 kJ/mol e. 1.61 kJ/mol IV. Which carbon atom is in the MOST oxidized state? a. a carbon in carbon dioxide b. a carbon in an alkyl group c. a carbon in a ketone group d. a carbon in a carboxylic acid group e. a carbon in an alcohol group N N N N NH 2 O OH OH O P O P - O O O - O - O A B C D CH 3 H 3 C HO H NH 2 H CH 3 H 3 C H HO NH 2 H CH 3 H 3 C HO H H NH 2 CH 3 H 3 C H HO H NH 2

Exam 1, BCHM 462 Name: Spring 2019 Page 3 V. Which statement about gluconeogenesis is FALSE? a. For starting materials, it can use carbon skeletons derived from certain amino acids. b. It consists entirely of the reactions of glycolysis, operating in the reverse direction. c. It employs the enzyme glucose 6-phosphatase. d. It is one of the ways that mammals maintain normal blood glucose levels between meals. e. It requires metabolic energy (ATP or GTP). 2. (12 pts) Circle all of the enzymes of glycolysis that involve the transfer of a phosphate group. (-2 pts for each incorrect answer, so don’t guess). Hexokinase Aldolase Triose phosphate isomerase Enolase Phosphohexose isomerase Glyceraldehyde 3-phosphate dehydrogenase Phosphofructokinase-1 Phosphoglycerate kinase Phosphoglycerate mutase Pyruvate kinase 3. (5 pts) Ethanol has a prochiral center. Identify the pro-S hydrogen by circling it. Don’t guess (+2 pts for assigning priorities,+2 pts for the correct answer, -2 pts for incorrect answer, 0 pts for no answer). CH 3 OH H H

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