Lab Report #7 - CHEM 3105
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Texas Tech University *
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Apr 3, 2024
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___
Lab Partners - ___
10.19.2023, CHEM 3105
TA - ___ Williamson Ether Synthesis of Phenacetin from Paracetomol
Purpose
The purpose of this lab is to synthesize a common analgesic using Williamson ether synthesis.
Reaction and Physical Properties
Reagents and Solvents
MW
g/mol
Density
g/mol
Amount
mmol
Boiling
Point
(
o
C)
Melting Point
(
o
C)
acetamino
phen
151.163
0.23 g
1.52
169
K
2
CO
3
138.205
0.42 g
3.04
891
iodoethane
155.97
1.940
160 µL
1.99
70-73
2-butanone
2.5 mL
79.6
dichlorome
thane
40
acetone
56
phenacetin
179.22
132-133
Safety Iodoethane
●
Hazard Statements → Combustible liquid. Harmful if swallowed. Causes skin, eye, and respiration irritation. May cause an allergic skin reaction. May cause
allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing genetic defects
●
Safety Statements → Wear ppe/face protection. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition
Anhydrous potassium carbonate
●
Hazard Statements → Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
●
Safety Statements → Wear ppe/face protection. Ensure adequate ventilation. Avoid dust formation. Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance.
Acetaminophen
●
Hazard Statements → Ensure adequate ventilation. Use ppe as required.
●
Safety Statements → Avoid contact with skin and eyes. Do not breathe dust.
2-butanone
●
Hazard Statements → Highly flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure.
●
Safety Statements → Wear personal protective equipment/face protection. Ensure adequate ventilation. Use spark-proof tools and explosion-proof equipment. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition.
Take precautionary measures against static discharges. Use only non-
sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded
Dichloromethane (methyl chloride)
●
Hazard Statements → May be corrosive to metals. Causes skin irritation. Causes serious eye damage.
●
Safety Statements → Ensure adequate ventilation. Do not breathe mist/vapors/spray. Wear personal protective equipment/face protection. Do not get in eyes, on skin,or on clothing. Do not ingest. If swallowed then seek immediate medical assistance.
Aqueous sodium hydroxide
●
Hazard Statements → May be corrosive to metals. Causes skin irritation. Causes serious eye damage.
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Related Questions
1015MSC Chemistry of Biological Systems II 2021
2.
What kind of results do you expect to see when the following compounds are mixed
together with the given test solution? Indicate positive or negative in the table below.
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AIR
لله لا
^•^•
????
suap
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? product
7.7.7.
?
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4. 6-2-2
hydroxyethyl)-1-methylpropyl ester
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5. Picaridin
6. Citriodiol
ethyl ester
7. IR-3535
e. butyl-3,3- dihydro-2,2-dimethyl-4-oxo-2H-
pyran-6-carboохуlate
f. para-menthane-3,8-diol
8. Rutgers 612
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Oc-OH
H2N.
H3C
CH3
Acid
Base
weutral
te Le
ecp at
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ciple Attempts Not allowed. This test can only be taken once.
ce Completion Once started, this test must be completed in one sitting. Do not leave the test before clicking Save and Submit
This test does not allow backtracking. Changes to the answer after submission are prohibited.
emaining Time: 52 minutes, 44 seconds.
Question Completion Status:
A Moving to the next question prevents changes to this answer.
Question 2
Reaction of arenediazonium salts with aryl benzene give....
o Aryl halied
Benzonitrile
Phenole
Azo dayes
A Moving to the next question prevents changes to this answer.
P Type here to search
1HUAWE
F1
F2
F3
F4
F5
F6
F7
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24
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5
6.
7
8.
Q
W
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T
Y.
us
A
H.
1S
C,
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DI
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13:22
4G O
5 ê © T Ô
1. What is the correct IUPAC name for the following compound?
Q A. Diphenylamine
1,1 diphenylamine
OCN,N-diphenylamine
O D. None of the above is correct
Add a caption...
> Status (Custom)
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gnment Score:
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O Macmillan Learning
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R
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F4
A carboxylic acid reacts with water to form a carboxylate ion and H₂O+. Complete the reaction.
IUPAC name:
VI
SPECIAL
e
Write the IUPAC name of the carboxylate ion formed in the reaction.
C6H₂COOH + H₂O=
5
5
IV
M
%
T
#
B
GA carboxylic acid reacts with water to for...
9
F5
achieve.macmillanlearning.com
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22
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X2
F6
MacBook Air
x²
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Resources ➡ Give Up?
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GA carboxylic acid reacts with
F11
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Check Answer
Attempt 3
F12
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Chemist
4:22 PM Thu Jun 16
...
@日
HW2 Synth Aromaticity -
x CHEM220 SU exam_dhill
Course Notes Unit 3
B
2
N
U
★
P
{T}
DA
6) Synthesis: Design a reasonable synthesis for the following:
Br
p=
OH
NOTE: You can use any other inorganic reagent, but no other organic reagents.
The molecule below is provided as a possible intermediate to go through in the
synthesis. It is not required that you make the molecule below in your synthesis.
classNotes
x HW2 Synth Aromati... x
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Complete the following reactions by providing missing reagents or products:
i.
ii.
iii.
OH
i.
ii. H3O+
OEt
i. CH3MgCl
ii. H3O+
MgCl
MgBr
i.
Xo
ii. H3O+
i. NaBH4
ii. H3O+
OH
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Fill in the reagents:
OH
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OH
O
H₂C-
H
O-H
2-hydroxypropanoic acid
(1)
The reagents and conditions are
1st step
2nd step
NaOH(aq), heat under reflux
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heat under reflux
B Cl₂, UV light
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CO₂, room temperature
D HCN, in presence of KCN(aq)
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