Lab Report #7 - CHEM 3105

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School

Texas Tech University *

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Course

3105

Subject

Chemistry

Date

Apr 3, 2024

Type

docx

Pages

7

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___ Lab Partners - ___ 10.19.2023, CHEM 3105 TA - ___ Williamson Ether Synthesis of Phenacetin from Paracetomol Purpose The purpose of this lab is to synthesize a common analgesic using Williamson ether synthesis. Reaction and Physical Properties Reagents and Solvents MW g/mol Density g/mol Amount mmol Boiling Point ( o C) Melting Point ( o C) acetamino phen 151.163 0.23 g 1.52 169 K 2 CO 3 138.205 0.42 g 3.04 891 iodoethane 155.97 1.940 160 µL 1.99 70-73 2-butanone 2.5 mL 79.6 dichlorome thane 40 acetone 56 phenacetin 179.22 132-133
Safety Iodoethane Hazard Statements → Combustible liquid. Harmful if swallowed. Causes skin, eye, and respiration irritation. May cause an allergic skin reaction. May cause
allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing genetic defects Safety Statements → Wear ppe/face protection. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition Anhydrous potassium carbonate Hazard Statements → Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Safety Statements → Wear ppe/face protection. Ensure adequate ventilation. Avoid dust formation. Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance. Acetaminophen Hazard Statements → Ensure adequate ventilation. Use ppe as required. Safety Statements → Avoid contact with skin and eyes. Do not breathe dust. 2-butanone Hazard Statements → Highly flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. Safety Statements → Wear personal protective equipment/face protection. Ensure adequate ventilation. Use spark-proof tools and explosion-proof equipment. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Use only non- sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded Dichloromethane (methyl chloride) Hazard Statements → May be corrosive to metals. Causes skin irritation. Causes serious eye damage. Safety Statements → Ensure adequate ventilation. Do not breathe mist/vapors/spray. Wear personal protective equipment/face protection. Do not get in eyes, on skin,or on clothing. Do not ingest. If swallowed then seek immediate medical assistance. Aqueous sodium hydroxide Hazard Statements → May be corrosive to metals. Causes skin irritation. Causes serious eye damage.
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