Case Notes - Drug Chem and Tox-1

15) Which one of the below given facts are not among the toxicological risk assessment? a) Identifying potential hazardous chemicals present in medical devices b) Re-designing the biomaterial to eliminate the toxic components c) Assessing the extent of a patient's potential exposure to these chemicals d) Determining the chemical's dose-response relationship 16) Which one the below givens are among the commonly employed in vitro tests to evaluate blood compatibility? a) Direct Contact test b) Colony Formation assay c) Genotoxicity d) Coagulation

(17360 Systane Part B CH3 CH3 CH3-CH₂-CH-CH-CH₂-OH Spell out the full name of the compound. Submit Request Answer Part C OH CH₂-CH3 P dy 44#1 BAKER -2221 51-19-145 ciation, Inc. OS WINE 19 25 OCT 2022 PM) Address Herbert Epstein 14773 Cumberland C DELRAY BEACH, F အင်းတင်း 46-135654 2 ^ [

6

Suspect #1: George Norman Suspect #2: Becky Baker George Norman recently Becky Baker is a world famous chef. She had just finished baking a cake at the time of the crime. The recipe called for baking soda. The formula for baking soda (sodium bicarbonate) is had an accident where he cut himself with a Alaia knife. He cleaned the wound with rubbing alcohol. The formula for rubbing alcohol Bak ing Seda NaHCOз. (isopropanol) is C3H80. Suspect # 3: Liz Lemon Suspect #4: Ben Linus Liz Lemon just had her nails Ben Linus had been walking done, and she still has traces of nail polish remover on her hands. Nail around in the rain for about an hour before the crime polish remover he was suspected contains acetone. Acetone of occurred. He The formula for Polish was dripping wet with water acetone is C3H60. renover at the time. The formula for water is H2o.

1) Which of the diet sodas have the highest concentration of caffeine? Which standard best reflects this concentration?

S (CQCL3) t σ 200 180 160 140 120 100 80 20 PPM 0 S (CDC13) 9 200 180 160 140 120 100 80 60 40 20 PPM 0 NH₂ T OH .OH །ཚིགས་.. OH

I Part 3 Discussion questions: Please answer in less than 2 paragraphs (20 points) 1. The FDA scientists have published 2 papers on the subject of sunscreen dermal absorption. What is different between the publications? The editorial page in the journal JAMA (Journal of American Medication Association) might help you answer this question.

Help Explain one effective or ineffective aspect of this graph.

Below is the therapeutic (effective) and lethal dose data for a new experimental cancer drug, compound X. What is the approximate ED50 value? lethal effective (therapeutic) dose curve dose curve 100 75 % subjects responding 50 25. 4 6. 8 10 12 mg of experimental drug, compound X 9 mg 3 mg 12 mg 6 mg 50%

3. In patients with early stage lung cancer, stereotactic body radiation therapy (SBRT) has greatly improved survival in patients unable to undergo surgery. In tumors 100 Gy 10 BED have demonstrated significantly improved survival, when compared with doses <100 Gy 10. What is the BED of the following protocol? Would you suggest increasing the dose, or does it appear adequate, assuming the given information? What would you expect as the most likely side effect of therapy for this patient? 3 fractions of 15 Gy delivered every other day.

What is analogue in medicinal chemistry? why it is so important in drug discovery?

لا © Macmillan Learning H H-C-OH H₂/Pt HO-C-H $ % do LO 5 H₂C-OH OCT 11 <6 Y MacBook Pro Resources Q2Q Erase Select Draw Templates More /// C 0 H G c 2Q & * ( 7 8 9 0 ) U 0 P SUD

2) Which of the diet sodas have the lowest concentration of aspartame? Which standard best reflects this concentration?

NO 85 At RI Astatin 209967 222.018 117 118 Uus Uuo Chunoctium unknown 84 Bi Po Pulonium [2002) 3 116 up Lv Livermorum nuncium own [298] unknown 69 70 Tm Thulum 168934 Yb Yicerbium 123055 102 101 Md No Mendelevium Nobellum 258.1 259.101 71 Lu Lutecium 174.967 103 Lr Lawrencium [262] DELL 2015 He org Stoichiometry (On Your Own) Solve the following stoichiometry grams-grams problems: 1) Using the following equation: 2 NaOH + H₂SO4 → 2 H₂O + Na₂SO4 How many grams of sodium sulfate will be formed if you start with 200 grams of sodium hydroxide and you have an excess of sulfuric acid? 2) Using the following equation: Pb(SO4)2 + 4 LINO3 → Pb(NO3)4 + 2 Li₂SO4 How many grams of lithium nitrate will be needed to make 250 grams of lithium sulfate, assuming that you have an adequate amount of lead (IV) sulfate to do the reaction?