bio literature project

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Apr 3, 2024

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BIL 151 Literature Search: Stem Cells and Regeneration Name: Lauren Dominguez Lab Section: 04 Keywords: stem cell differentiation, stem cell therapy, regenerative medicine, drug therapy, tissue, gene therapy, planaria, differentiation List three relevant articles you found in your search, in proper format. If you are not sure of proper format, here is a guide (Search “style examples” in that page to view a list of examples of how to cite journals, books, etc.): http://www.sciencemag.org/site/feature/contribinfo/prep/res/refs.xhtml 1. Srijaya, Thekkeparambil Chandrabose, et al. “Advancing Stem Cell Therapy from Bench to Bedside: Lessons from Drug Therapies - Journal of Translational Medicine.” BioMed Central , BioMed Central, 4 Sept. 2014, translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0243-9. Main theme of article: This scholarly article describes the eagerness of scientists to u tilize stem cells to treat diseases and fix damaged organs. There are some questions and further research needs to be done on how to use these cells effectively in clinical trials such as dosage, best route of administration, and duration. The article suggests that applying lessons learned from synthetic drug therapies and trials could help the overall effectiveness of stem-cell based therapies. Why is this article relevant to your project? This article is relevant to my project because it discusses challenges and potential solutions r ega rding the usage of stem cells for regenerating damaged tissues and organs. It emphasizes that while stem cell therapies hold promise for regeneration, there are uncertainties on things such as how to administer the cells effectively. Emphasizing innovation in stem cells is essential because it not only drives scientific progress but has the power to transform the way diseases are treated. 2. Jin, Ye et al. “Application of stem cells in regeneration medicine.” MedComm vol. 4,4 e291. 17 Jun. 2023, doi:10.1002/mco2.291 Main theme of article: The main idea of this article is that regeneration is a complex process influenced by many factors such as inflammation, proliferation, and tissue remodeling. It discusses the challenges in delivering stem cells and their exosomes to the skin, proposing various nano formulations to enhance their effectiveness in healing and regenerating skin and bone tissues. Why is this article relevant to your project? This is significant to my project because it sheds light on the process of natural tissue repair, specifically for skin and bone. These insights can have a significant impact on enhancing the quality of life for individuals by offering better therapeutic solutions.

3. Bohr, Tisha E, et al. “Planarian Stem Cells Sense the Identity of the Missing Pharynx to Launch Its Targeted Regeneration.” eLife , eLife Sciences Publications, Ltd, 22 June 2021, elifesciences.org/articles/68830. Main theme of article: The article focuses on planarian flatworms, and how they possess regenerative abilities and can respond to injuries in terms of their stem cell behavior. They can detect the identity of missing tissues and tailor their responses accordingly. The study looks at how planarian stem cells respond when certain organs, like the pharynx or head, are removed compared to injuries affecting multiple body tissues. Why is this article relevant to your project? This is relevant to my project because the findings of the study could offer valuable insights for projects related to stem cell-based regeneration or regenerative medicine. Furthermore, planarians are an excellent model for comparative biology. Their regenerative processes share some similarities with humans and other animals, making them a valuable model for studying biological mechanisms.

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