3D-Printing Case Study

AS well as sustaining the ability to produce prosthetic limbs, 3d printing is also extremely useful for creating artificial organs for needy patients in hospitals. But not only organs, but skin, bone, cartilage, blood vessels, surgical tools as well as even hearts and stem cells can just as well be made by these magnificent machines.

The field of bioprinting, using 3D printing technology for producing live cells with extreme accuracy, could be the answer to many of the problems we as humans face in the medical field. It could be the end to organ waiting lists and an alternative for organ transplants. In 3D printing technology lies the potential to replace the testing of new drugs on animals. However, the idea of applying 3 dimensional printing to the health industry is still quite new and yet to have a major impact. Manufacturing working 3D organs remains an enormous challenge, but in theory could solve major issues present today.

In a study conducted through the U.S. Department of Health and Human Services on “average 79 people will receive an organ each day; however, an average of 22 people die each day” waiting for transplants that cannot take place because of the shortage of donated organs (U.S. D.H.H.S). The average amount of patients waiting for an organ can reduce to zero with the continued development of 3-D printers. 3-D printing is a process of making three dimensional solid objects from a digital file. The digital file is uploaded onto a computer software, and then the 3-D printer prints the digital file out onto different materials. The materials include plastic, resin, nylon, sandstone. The finish products become replicas of the digital file, and what was an idea is now a reality. Therefore, 3-D printers will one day be the future of organ transplants because over the past twenty years the technology industry has rapidly grown into the focal point in society. From advancement in communication, to the medical field, science and technology has shaped this world today. Thus, the American Government should invest more money into the medical field budget because the research conducted on new technology (3-D Printers) leads to more lives saved, and expands the opportunity of future medical breakthroughs.

Secondly, advanced 3D printing applied to the medical field can be utilized in an Engels non capitalist technology drive society to impact the area of safety. In this utopian society, advanced 3D printing will have the capabilities to print synthetic tissue and organic tissue that can bond to the patient’s cells. In effect, this helps the patient’s wound heal faster. This type of advanced 3D bio printing can save many lives

Doctors and engineers have been working on another way to get organs a faster and more efficient way. Using 3D printers can help with their problem. They have worked on using a 3D printer to make organs that are a perfect match for patients. This can be very useful it can get an organ ready in a short amount of time helping the patient recovery faster as well. Organ transplants are hard to come by. One you have to be put in a waiting list, and people are usually on that list for a long while, just waiting for a perfect match to come. But sometimes it takes to long and some people die while still on the waiting list. But when an organ finally does come they feel bad because someone had to die in order for them to use it. So Dr Ali Khademhosseini is trying to use 3D printing to help solve this problem. His theory is he can make organs from a 3D printer, which can make the waiting list decrease faster and have people not have to die in order for a perfect match. 3D printers have been used to make Human cells, tissue, and blood vessels. But making something like a heart is much more difficult. Because you have to make the beating and pumps. (Mesley). There have been problems in the past that have just know started to show in some people. "Viruses aren't the only worry, and here too the past may serve as a guide. In 1956 injections of human growth hormone became a standard therapy for children failing to develop properly. The hormone was extracted from

In the past, the only way to replace diminished cells, tissues, and organs was from organ transplantation. An organ donor was needed, and the tissues would be surgically removed from the donated body and placed into the recipient. Due to the current research being conducted, it is believed that tissue engineering and organ printing can contribute to the process of improving and saving lives.

3D printing is definitely a huge advancement in Technology! However, very controversial. Although, it has multiple benefits in our society in Medical health practices & Engineering speed, it can also be used for illegal purposes. Now, does the bad outweigh the good? That is the question debated today. I see the whole concept in only 2 large points. It will greatly help people who are desperately in need for transplant organs. It will drastically reduce the organ waiting list and once perfected, our life span should be bumped up a decade or so. On the other hand, what if someone down the road you'll be able to completely recreate a human being in it's entirety? Would we harvest them for their organs? Would it be fair? What if it falls in the

In the future, the technology will be widely accepted since it can be used to create complete organ, to test newly developed drugs on manufactured cells instead of animals and human cell, to imprint cells directly onto a human body, thus reducing the wait time for organ transplantation, and save time and cost associated with drug research. An absolutely favorable position of customized organs is designing organs utilizing a patient 's own particular cells. With this methodology, there would be no issues with dismissal, and patients wouldn 't need to take the powerful anti-rejection medications that are presently required (Cooper-White, 2015). According to the Organovo company, the formation of a suitable liver is a crunch second for the bio-printing and drug industry since it demonstrates 3D printed tissue can be preserved successfully for a sufficient time to test the impacts of medications on it or insert it in a human body where it can further mature (Mearian,2013).

Bioprinting offers the ability to create a 3D biomimetic tissue by patterning cells and, in some approaches, multiple cell types with precise and reproducible spatial control. In order to create these organs a researcher must start off with a bioink consisting of compounds with a chemical structure consisting of polysaccharides and/or proteins. Some of the compounds include, but are not limited to agar, collagen, silk, elastin, and chitosan. These bioinks are then infused with additives that include growth factors, cytokines, and extracellular matrix (Bioprinting 4-12). Bioprinting then “moves from the laboratory to the clinic sources, clinical grade cells will be necessary to support the assembly of different constructs” This is where stem cells from the patient, if possible, are utilized to prevent the use of immunosuppressive drugs. (Bioprinting 4-12). Once everything is loaded into the biopen, it is then loaded into the bioprinter (fig 1, 2). Researchers are then able to make tissues, organs, and many other structural components.

Anthony Atala, in his 2011 Ted Talk, Printing a Human Kidney, tells of printing a bladder. He explains that they use a small piece of the patients original bladder. They then print a scaffold and let the cells grow on the scaffolding in an “oven like device” that has the “same conditions as the human body -- 37 degrees centigrade, 95 percent oxygen” Weeks later, the organ has grown and it is ready to be placed in the patient. Atala explains that “For these specific patients, we actually just suture these materials. We use three-dimensional imagining analysis, but we actually created these biomaterials by hand.”Luke Massella, a patient who received a 3D printed organ because he was born with spina bifida that prevented his bladder and kidneys

Current medicine up has typically depended on the human body as its main model in the creation of organs for transplants and teaching methods. Up until recently X-Rays and cadavers have served as primary reference points for the structure of bones and were used as universal models for almost every human. However, now with the introduction of the 3D printer in the medical field, the possibilities and advancements are growing and the options are becoming endless. Using scientific research on current studies in the medical field will demonstrate what 3D printing is, how 3D printing is revolutionizing surgical procedures and teaching methods, and what actions should be taken to ethically use this invention.

With the very limited supply of organs, 3D printing creates functioning organs without a donation from a living organism. The definition of 3D printing from Charles W. Hull, the inventor of 3D systems, states that “...thin layers of a material that can be cured with ultraviolet light were sequentially printed in layers to form a solid 3D structure” (Murphy & Atala 773). The sheer narrow sheets play a vital role in bioprinting. They allow the printers to develop functional, layering individual cells, proteins, and an extracellular matrix. The three basic types of 3D printing include biomimicry, independent self- assembly, and miniature tissue blocks. The creation of the 3D structure creates all the difference between these types of printing. Three dimensional structure approaches include, creating exact duplicates of the cells and tissues with extensive knowledge, using a developing embryo as a template or using microscopic tissues to assemble into a larger developed tissue (Kalaskar). In other words, all these paths to bioprinting end up with a 3D structure but require different knowledge and materials. They all contain their own sets of challenges.

First you start with a blueprint outlining the desired structure of the organ(22). Then you move onto the 3d printing machine, such as a Regonovo capable of running the inkjet sub-method of 3d printing(15). This type of 3d printing is designed to build the desired object, or in this case organ, by laying down the material layer by layer and allowing it to fuse together along the way, allowing it to maintain structural integrity. Within a bioprinter there is bioink, which is a cell filled

In the past two decades, 3-D printing has grown from a “niche manufacturing process” to a $2.7 billion industry, responsible for the fabrication of all sorts of things: toys, jewelry, machine parts, and even food (Griggs). But now scientists are working to apply that same technology to the field of medicine. In labs around the world, like the one at Organovo, scientists have begun to print prototype body parts including heart valves, ears, artificial bone, joints, menisci, vascular tubes, and skin grafts, (“Bioprinting”). The innovation of this technology lies in the fact that it generates actual living human cells, allowing for the reproduction of organs and tissue that “mimic the form and function of native tissues in the body” (“Bioprinting”). Since its

In this paper, I intend to discuss the ethical debate surrounding 3-Dimensional bio-printing for the manufacturing of human tissue and organs. In order to do so, I will be examining the history and progression of the 3D bio-printer in the current global market, the consumer need for transportable organs (which includes both the pursuit of life extension as well as cosmetic reasons), and the political and economic interests of this disruptive innovation. Through research conducted by The Economist, Gartner, Inc., and several research journals such as Nature Biotechnology, I will be able to examine bio-printing from a technical standpoint – what it is and how it works, since it is still in its rudimentary stages – as well as from