Abstract Purpose: This study aimed to explore the value of IHC4 in predicting pathological response after neoadjuvant chemotherapy in patients with hormonal receptor (HR)-positive breast cancer (BC). Materials and Methods: In this retrospective exploratory study, data for 68 HR-positive BC patients who received neoadjuvant chemotherapy were recorded. IHC4 scores were calculated based on estrogen receptors/progesterone receptors, Ki-67 and HER2 status. Logistic and ordinal regression analyses in addition
21482511 Word count: 1500 General comment This paper explores the concept of financial stability, recognising that some countries have learnt to achieve this state over time, while others have not. The study uses empirical evidence in conjunction with several nation-based case studies to account for potential causes of this discrepancy. The interplay between financial development, financial globalization and financial crises is established, and it is suggested that financial development is
dependencies b) by means of estimated dependencies predicting new output. Such ability goes a long way in analyzing large data sets that may have complex or noisy datasets such as proteomic or genetic datasets. Machine learning utilizes statistics, probabilities and optimization tools to classify and predict new trends in the data however it’s use of Boolean logic(AND, OR, NOT), conditionality (IF, THEN, ELSE) makes it mimic the human approach of learn and classify[1]. Machine learning techniques are
and to reduce the vascularity of the gland. The major complications of surgery—bleeding, laryngeal edema, hypoparathyroidism, and damage to the recurrent laryngeal nerves—are unusual when the procedure is performed by highly experienced surgeons. Recurrence rates in the best series are <2%, but the rate of hypothyroidism is only slightly less than that following radioiodine treatment. The main advantages of subtotal thyroidectomy are rapid control of the disease and a lower incidence of hypothyroidism
(RMS) (65–70% event-free survival rate) [2, 3]. Though EWS and RMS are considered radiosensitive, the proportion of patients whose primary tumors are treated with external-beam radiotherapy (EBRT) alone has steadily declined over the past 30 years [4]. Increased awareness of the late effects of radiotherapy (particularly second malignancies and growth disturbances) and advances in imaging and orthopedic surgery has increased the use of surgical management for these tumors [5]. Due to the fact that
chemotherapy regimen of 4 x FEC-100 cycles, she was prescribed adjuvant Tamoxifen hormonal therapy for five years, which is shown to decrease the probability of breast cancer recurrence.10 Mrs. Smith’s respiratory complaints are diagnosed as a lung metastasis (advanced breast cancer, stage IV), upon which, her consultant decided to adhere to NICE guidelines and start her on Anthracycline chemotherapy, particularly, liposomal Doxorubicin.11 A study conducted by the CAELYX Breast Cancer Study Group (O’Brien
this, because the problem of chosen language is linked so intimately with the problems of power, there is a need to re- conceptualize the notion over expertise for legitimating the experience and knowledge from the society of the learners. Culture presents one of the strongest challenge to learning English since most ESL students are adults who have been exposed to an extreme cultural background that conflict with English or western culture which comes with learning of English. The authors hold the
Case Example Thomas Lanier Williams, or Tennessee Williams as he was later known, was born on March 26, 1911 in Columbus, Mississippi. He was the second of three children, he had an older sister Rose and a younger brother Dakin, born to Cornelius and Edwina Williams. Because Williams’ father was a traveling shoe salesman for much of his early childhood he and his family lived with his maternal grandparents. However, due to the nature of his grandfather’s work as an Episcopal minister the family
burdening the individual, their family and the society in general. Most episodes of depression is resolved without treatment, except for patients suffering from chronic depression and in some cases where the person who has recovered experience recurrences. Because of this nature and “its frequent co-morbidity with other chronic illnesses…depression is considered to be the condition that is most responsible for health decrements worldwide” (DeRubeis et al., 2008, p. 1). Therefore, it has become a
Design Proposal Report for Fatigue Monitoring System (FMS) By Alvin Kuan, Sarah Fink, Shian Su and Suliman Altaleb 1. Abstract This paper presents some background briefing, implantation, ethical responsibility, and action plan of FMS design plan. FMS is a model purposely designed to detect and measure fatigue variables, i.e., blinking rate, yawning rate and head tilt for fatigue predictions. In addition, FMS will establish a crude estimate of fatigue and warns the user if a threshold has been