Introduction
Osteoporosis is a chronic skeletal disease resulting from deterioration in micro-architecture marked by general impairment of bone mass and a consequent decline in bone strength (1, 2). This manifests as an increase in the propensity to fragility fractures of the vertebrae, wrist, hip and other skeletal sites. Fractures as a result of fragility lead to increasing morbidity and consequently mortality in this population (3). It may also impair mobility, resulting in decreased quality of life and significant social and financial burden (4, 5).
Osteoporosis is often associated with depression, also a high prevalent, chronic and debilitating disorder, characterized by decreased mood, impaired cognitive functioning, and low energy
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The aim of this article is to summarize the evidence regarding the effects of serotonergic antidepressants on bone density and its implications for clinical care.
Depression, bone mineral density, and fractures
Several reports support the notion that depression may cause bone deterioration and consequently increase the risk of osteoporotic fractures in adults, including three meta-analyses, which provides evidence of an association between depression and low BMD (10-20). Even after adjustment for known risk factors for osteoporosis, BMD remains negatively associated with the presence of depressive symptoms in older subjects (21). There is further some evidence suggesting that decreased BMD occurs at the beginning of depression, and not just as a final consequence (22). A recent meta-analysis on the topic specified that depressed individuals display lower BMD at the spine, hip and forearm, with a stronger association observed for pre-menopausal than for post-menopausal women, probably due to the fact that post-menopausal women present other risk factors for osteoporosis, such as lower estrogen levels and physical inactivity, thus hampering the association (17). The same results were replicated in a meta-analysis conducted by Wu et al., which showed decreased BMD at the spine and hip for subjects with depression when compared to
Osteoporosis is a progressive bone disease that is characterized by structural deterioration of bone tissue and reduced bone mineral density(BMD). Consequences include increased pain, increased risk of fracture, loss of mobility, and death (Osteoporosis Canada 2014).
The management of osteoporosis patients start with the diagnosis by rolling out secondary causes and then confirm it by measuring bone mineral density (BMD). After that, begin the treatment with lifestyle changes, pharmacological medications, and surgery for some fractures if needed. In this essay I will cover generally the diagnosis, treatment, and prevention of osteoporosis in five steps.
Osteoporosis, meaning porous bone from the Greek language, is bone disease that gradually and steadily wears down bone tissue and its living cells. This wearing down will eventually cause the cells of bone tissue to degrade and die, leaving their “scaffolding” to be the only things only bone together. Without living cells to take up a home in this scaffolding, minor injuries such as falls, bumping into objects, and pressure that would normally be completely and would not pose any threat to bone tissue suddenly becomes a real hazard that can easily pose a threat to one’s well-being. Osteoporosis affects a person skeletal system.
Osteoporosis is one of the major contributors to the overall physical and psychological manifestations of frailty associated with aging. Osteoporosis-related fractures are a common cause of the morbidity and mortality associated with aging. Approximately 1 in 3 women and 1 in 5 men will experience an osteoporosis-related fracture during their lifetime.14 Osteoporotic hip fractures are associated with a high rate of subsequent mortality and a prolonged period of months to over a year before mobility is regained.15 Predominantly, existing treatments for osteoporosis fail to harness osteoblast biology precisely because many of the molecular pathways that regulate osteoblast function remain largely unknown. Loss of bone mass is caused by high numbers of osteoclasts. Decreased production of estrogen and
Osteoporosis is a disease in which bone tissue is normally mineralized but the mass of bone is decreased and structural integrity of trabecular bone is impaired. Cortical bone becomes more porous and thinner, making bone weaker and prone to fractures. The World Health Organization (WHO)(1994) has defines postmenopausal osteoporosis abased on the bone density. Bone density is based on the number of standard deviations away from the mean bone mineral density of a young adult reference population, a T-score. Normal bone mass density is 0 to -.99 standard deviations, low bone density (osteopenia) is -1.0 to -2.49 standard deviations, osteoporosis is labeled as less than or equal to 2.5 standard deviations, and severe osteoporosis is less than or equal to 2.5 standard deviations and included a bone fracture.
As generally stated in the introduction, osteoporosis is a skeletal disorder that involves the strength and integrity of one’s bones. The WHO defines osteoporosis as, “a systemic skeletal disorder characterized by low-bone mass, deterioration of bone tissue, increased bone fragility, and its susceptibly to recurrent fractures.” 2 The most important factor to take into account when addressing osteoporosis is the mass of bone, also referred to as, bone mineral density (BMD). As bone mass begins to decline, typically in the older population, specifically postmenopausal women, individuals are at an increased risk for fractures.3 As a result of this serious condition, many people are affected by morbidity, mortality, and economic difficulty.1
Osteoporosis is a detrimental bone condition, the tissue in the bones deteriorate and thus the bones become progressively brittle which presents a risk for rupture. Osteoporosis impacts more than 44 million Americans and is linked to a suggested 2 million bone fractures each year. According to the National Osteoporosis Foundation, the amount of fissures due to osteoporosis may escalate above 3 million by the year 2025. Osteoporosis is typically undetected and advances with slight warning signs until a fissure ensues. Effects of osteoporosis encompass height reduction and a curved upper back, anyone can have osteoporosis, however it is prevalent in elderly women and many may break a bone due to this condition. Recovery and prevention are vital in combating osteoporosis, though it may never be eradicated one can take measures to stabilize bone density and gain strength.
Osteoporosis is a degenerative disease of the bones generally brought on by the process of aging, unfortunately there can also be a number of underlying or secondary causes; however, preventative care and drug treatments can minimize the severity of this prevalent disease. Osteoporosis has been estimated to affect more than 200 million people worldwide (Bethel, 2015). According to the National Osteoporosis Foundation, 9.9 million Americans have osteoporosis and an additional 43.1 million have low bone density.
The term osteoporosis describes bone loss that is extensive enough to increase the risk of fracture. The term is a general one, not related to any specific cause for the bone loss. Nearly all people with OI have osteoporosis, because they do not develop appropriate bone mass at any age. Women and men with OI can experience additional bone loss, such as age-related bone loss, superimposed on a background of OI. Symptoms of additional bone loss may appear at a younger age than commonly seen in people who don’t have
Osteoporosis is a skeletal, chronic disease, which is characterized by diminished bone strength and deterioration of bone tissue, that results in increased fracture risk, especially in the wrist, hip, and spine (CDC,2012;NIH, 2001). In osteoporotic patients, bone mineral density (BMD) is ≥2.5 standard deviation below the mean for healthy young adults at the spine, femoral neck or total hip (Lewiecki et al., 2008).The disease is a common old-age problem and most prevalent among postmenopausal women and the elderly with high prevalence affecting 1 in 3 women and 1 in 5 men by the time they reach
According to Kohl & Murray (2012), osteoporosis is defined as a musculoskeletal disorder that results in “low bone mass and structural deterioration of bone tissue” due to “low physical activity levels”, which increases the risk of bone fractures (p.118). Low bone mineral density (BMD) causes bones—most commonly in the hip, vertebrae, wrist, and pelvis-- to become fragile, making it easier to break. Discomfort and disability will be added to the body’s ability to function and when performing daily tasks. Among the 52 million Americans who have osteoporosis, an estimation of 2
Osteoporosis is characterized by low bone mineral density and the decay of bone fibers resulting in weaker bones; making bones deteriorated and vulnerable to fractures (Sharma and Khandelwal., 2010). Osteoporosis is a disease that affects men and women. According to a study half of the women and one-eighth of the men would suffer from bone fractures caused by osteoporosis during their life span (Anders, Tuner, and Freeman, 2013). Osteoporosis turns into a considerable health problem mainly for women after menopausal years; as women aged their Bone Mineral Density (BMD) decreases as the risks of bone fractures increase (Mendoza-Romo et al., 2014). Why are women at risk of developing osteoporosis? Bone health is directly
Fractures due to bone fragility results in an economic burden and reduces the quality of life due to fear of falling and fear of loss of independence (Giangregorio, 2008).
Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps (nof.org). This skeletal disease is characterized by the increase in the fragility of bones as a result of reduced bone mass density and the deformation of the structure of bone tissue (Angin,Erden,Can, 849). Many patients with osteoporosis are instructed by their doctor to exercise; as this will improve their rehabilitation of this disease and lessen the pain associated with it.
Osteoporosis is described by the NHS as “a condition that weakens bones” and is fairly common, affecting roughly 3 million, with more than 300,000 people receiving treatment each year. Fractures are extremely common as the weakened bones are more susceptible to damage, even coughing may cause vertebral damage. Osteoporosis can be classified as type I or II, “both type I and type II osteoporosis occur through an imbalance between total skeletal bone formation and bone resorption which is sustained over many years” (Theobald, 2005), and are related to a lack of vitamin