A Brief Note On Rheumatoid Arthritis And Cxcl 10 / Il 10 Gene Therapy1 Essay

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the

Rheumatoid Arthritis(RA) is the most common type of autoimmune arthritis. RA is a progressive and debilitating musculoskeletal disorder that affects the joints symmetrically, causing a range of systemic effects. What it causes is still not well known; nevertheless, findings of new research points towards a believe that it is triggered by a defective immune system, which causes the release of inflammatory chemicals. These chemicals cause damage to cartilage and bone, usually affecting the wrists, the joints of the hand, including the knuckles, the middle joints of the fingers and feet. While this condition can affect any joints, besides, important body organs such as the eyes and the lungs can also be affected by the inflammation that occurs as a result of this chronic condition. Only in America 1.3 million of people are affected by this ailment, and 75 % of them are mainly women. Its onset usually occurs between fourth and sixth decades; however, RA can occur at any age("Diseases And

Rheumatoid arthritis is one of the incurable diseases and turns chronic with progressive inflammatory of the synovial lining of peripheral joins. It is characterized by symmetric, chronic, and deforming polyatrhitis that causes long term joint disability when not controlled early. Considering there is no cure for this disease, management focuses on pain and inflammation reduction in order to prevent destruction of joints while at the same time preserving and improving on the functionality of the patient (Varatharajan et al, 2009).

Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small

Rheumatoid arthritis is an autoimmune inflammatory disease which causes inflammation on joints leading to disability. The deterioration is caused by constant attack in the synovium leading to synovial cells to a rough and grainy tissue eventually allowing the bones to crumble away. The disease currently has no cure and scientists are thriving to find a target specifically aiming at the bones.

Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small hand joints. RA is

Huston states,” Joints are extremely damaged and the only thing that will help the pain at this point is replacing the joints.” She applies cold therapy to reduce pain in the joints and does range of motion three times. RA treatment includes disease modifying anti-rheumatic drugs (DMARDs), non-steroidal anti-inflammation drugs, and biologic therapy (Walker, 2012). Physician uses DMARDs as a common treatment for patient who just got diagnosis of RA, and the drugs have side effect that nurses need to educate patient about (Firth, 2012). Biologic drugs are another RA treatment available for patient. Biologic drugs are very expensive and their main target are cells, molecules, B-cell, and tumor necrosis that start the disease process. Hot and cold packs are common treatment used to reduce inflammation and allow client to complete their task, and move around (Walker,

Rheumatoid Arthritis is a systemic autoimmune disorder. There are more than 100 different types of Arthritis, yet it is estimated that it affects approximately 1% of the population in the Western World. The disease is generally diagnosed in middle aged adults and the elderly. In rarer cases, children can also develop the disease and it is called Juvenile Rheumatoid Arthritis. Women are three times more likely to have rheumatoid arthritis than men. (Stevens) Many people living with Rheumatoid Arthritis appear to be healthy individuals, but suffer internally. Today, I will discuss what rheumatoid arthritis is, how it is diagnosed, and how it affects the body.

Rheumatoid Arthritis known as RA is an autoimmune disease which the body’s immune system mistakenly attacks the joints. In a healthy individual the immune system protects by attacking foreign substances like bacteria and viruses. When this happens the body will create inflammation that causes the tissue that lines the inside of the joints known as the synovium to thicken, which creates swelling and pain around the joints. If the individual is to go a prolong period without treatment for RA it can damage the cartilage and over time the loss of cartilage the joint can then become loose, unstable, painful and most lose their mobility. Joint deformation can occur and the damage to the joint cannot be reversed.

Rheumatoid arthritis is a chronic, systemic autoimmune disease characterized by inflammation of connective tissue in the diarthrodial (synovial) joints, typically with periods of remission and exacerbation (Lewis, Dirksen, Heitkemper, Bucher, & Camera, 2011). The etiology of rheumatoid arthritis is unknown. Autoimmunity and genetic factors are believed to be important in the development of RA. Genetic predisposition appears to be important in the development of RA (Lewis et al., 2011). The strongest evidence for a familial influence is the increased occurrence of a human leukocyte antigen (HLA) (Lewis et al., 2011). Smoking can increase the risk of RA for a person who has a genetic predisposition. Autoimmunity theory suggests that changes

Rheumatoid arthritis (RA) is an autoimmune disease that affects the cartilage in one 's joints, it is not curable, it can not be stopped, only the pain itself can be lessened. In an average person’s body, the immune system has one job; to attack foreign substances that may enter the body. With the 1.5 million people in the United States that have been diagnosed with rheumatoid arthritis, their bodies are “tricked” or mislead into thinking that the cartilage within their joints is what is foreign. Once their immune system attacks the joints, it causes inflammation within, which then in turn leads to the synovium (lining of the joints) tissue to thicken. The synovium makes a fluid that acts as a lubricant to the joints and helps everything move freely. Once that fluid is gone, swelling and pain is experienced next. After awhile, the cartilage within the joints begins to disintegrate and will eventually cripple the individual. Along with knowing exactly what RA is, by the end of this paper you will know signs and symptoms within the oral cavity and systemically, and you’ll be familiar with how nutrition is related to the progression of this disease.

Rheumatoid Arthritis is an autoimmune disease that attacks the musculoskeletal system. This means that certain cells of the immune system do not work properly and start attacking healthy tissues — the joints in RA. The cause of RA is not known. When inflammation occurs in the joint, immune cells release chemicals which attack the cartilage and bone, causing the swelling that leads to pain. This type of disease can cause many difficulties in the body itself. Such as pain, stiffness, swelling in joints, limited motion, loss of energy and appetite, low fevers, dry eyes and mouth, firm lumps at extremities and body discomforts. Rheumatoid arthritis mainly affects the small joints in the body like hands and feet. In rare cases, rheumatoid arthritis

Rheumatoid Arthritis is an inflammatory and autoimmune disease that occurs when your immune system mistakenly attacks healthy joints, causing horrific symptoms such as immense pain, swelling, stiffness, and loss of physical function (What is rheumatoid arthritis (RA)?). Joint pain which affects over seventy million Americans each year, can be discomfort, pain, or inflammation arising from any part of a joint, including cartilage, bone, ligaments, tendons, or muscles (Rheumatoid Arthritis.). It is very common in Rheumatoid Arthritis and Osteoarthritis, which is inflammation or pain from within the joint itself. It can be mild, causing soreness only after certain activities, or it can be severe making even limited movement, particularly bearing

Rheumatoid Arthritis or (RA) is an autoimmune disease that attacks the joints and connective tissue. The result is inflammation that produces permanent damage in the joints. Rheumatoid arthritis is a chronic syndrome that tends to be progressive and destructive as compared to Osteoarthritis or (OA), which is more of an age related disease caused by “wear and tear” of the joints. In contrast to (OA), rheumatoid arthritis is characterized by inflammation mostly of the joints, but is a general body disease.

The first X-SCID gene therapy trial used a moloney murine viral vector with the c transgene in two patients with X-SCID. One patient had a missense mutation in IL2RG which resulted in a receptor in the cellular membrane but without a cytoplasmic tail and therefore not functional. The other patient had a frameshift IL2RG mutation which deleted exon 6 and resulted in a truncated receptor that was not expressed on the membrane. Their CD34+ T cells were removed and transfected for three days, at which point they were infused back in to the patient. Around 40% of the infused cells contained the transgene. 15 days after transfusion, circulating T cells containing the transgene were able to be detected circulating in both patients by PCR. The