A Clinical Syndrome

1974 Words Sep 3rd, 2014 8 Pages
Introduction
Sepsis is a clinical syndrome that arises from inflammatory response to infection. The response from the host is associated with immune, hormonal, metabolic, bioenergetic and autonomic nervous system modification. This is associated with an overall catabolic state, excessive adrenergic stimulation, high catecholamine levels and myocardial depression. This effects are mainly mediated via cathecholaminergic action and cytokine production (1). β-blockers modulate both these pathways. There are several studies that have shown the benefits of β-blockers in sepsis. Animal studies have shown benefits of β-blockers (2,3,4,5). To date there is no published systematic review on the effect of β-blockers in sepsis. We sought to summarize the evidence from all human studies on the effect of β-blockers in sepsis.
Materials and methods
Methods of inclusion and analysis were developed in accordance with the Cochrane collaboration guidelines (6).
Search methods
Medical librarian (SP) and 2 authors (CJC, SG) undertook a comprehensive search of the published literature. We identified references for this systematic review using Medline, Embase and the Cochrane register of controlled trials with search terms sepsis (MeSH term) OR "beta blockers" (MeSH term) OR "beta adrenergic blocking agent*"(all fields) OR "beta antagonist*" (all fields) OR "beta adrenergic antagonist*" OR "beta-adrenoreceptor antagonist*"(all fields) OR "beta adrenergic receptor antagonist* (all fields).…
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