A Comparative Group Of Healthy Controls

1148 Words Mar 1st, 2016 5 Pages
The study aimed to have a comparative group of healthy controls, which for the purposes of this presentation were excluded (n= 159). Patients currently with pouches and on steroids were excluded from this sample as well leaving a total of 560 eligible patients with IBD had a colonoscopy, at which time, an in-depth interview along with blood and biopsies were obtained. Following the enrollment of patients into to study, chart review was conducted to collect additional information such as inflammatory markers, serology and phenotypic information about disease behavior and location. Participants were predominately; male (51.8%) white (86.8%), average age was 44 (SD +/- 15 years of age), and its distribution is shown in Figures 1 and 2, with a disease breakdown of Crohn’s Disease (n= 340, 60.7%) and UC (n= 220, 39.3%) as well as average number of years with IBD diagnosis 16 years (SD +/- 12 years).

Statistical Analysis
A distribution of age as compared to their PHQ-8 scores was done relative to disease activity (Figures 2 and 3). The binary logistic regression using PHQ-8 and Manitoba IBD index showed a strong, positive correlation (r=0.93) (OR = 2.52, 95% CI: 1.3-9.4, p < 0.001). IBD patients with moderate to severe depression are 2.52 times more likely to report worse IBD symptoms as per the Manitoba IBD Index as compared to those with none to mild depression. Furthermore, males are 1.50 times more likely to report having active disease as compared to…
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