A Promising Treatment Modality For Cancer

2056 Words Apr 6th, 2016 9 Pages
Immunotherapy is a promising treatment modality for cancer as it can promote specific and durable anti-cancer responses. Systemic adoptive cell therapy (ACT) is an emerging form of cancer immunotherapy showing tremendous potential in clinical studies aimed at treating solid cancers. The success of promising anti-cancer adoptive cell therapies relies on the abilities of the perfused CD8+ T lymphocytes to gain access to and persist within the tumor microenvironment to carry out their cytotoxic functions. The success of cancer adoptive cell therapies depends on the expansion of tumor infiltrating lymphocytes (TIL) from patient derived tumors for their personalized systemic infusion back into individual patients, along with the capacity of these antigen experienced and activated TIL to access and persist within the tumor microenvironment to carry out their cytotoxic functions, anticancer responses. This propose a new method for their local delivery as a living concentrate, which will reduce the numbers of cells required for treatment as well as it will enhance site-specific mobilization. Using combinations of sodium hydrogen carbonate and phosphate buffer as gelling agents with Chitosan, novel injectable chitosan-based biocompatible thermogels (CTGels) having excellent mechanical properties, cytocompatibility, and acceptable physicochemical properties such as physiological pH and osmolality, macroporosity and can be developed so that T cells encapsulated in this formulation can…
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