A Research Study On Plasmodium Species

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Introduction Plasmodium species (sp.) is the caustic protozoan parasite known to cause malarial disease. One of the most common disease in tropical and subtropical regions of the world is malaria, causing 500 million malarial infections with 1-2 million deaths per year (Tangpukdee, Duangdee, Wilairatana, & Krudsood, 2009, p. 93). In addition to the severity of the disease is dependent on the species of Plasmodium acquired by the patient with P. falciparum being the most severe and fatal while P. vivax, P. ovale, P. malariae and P. knowesi cause acute disease that is rarely fatal. Furthermore, the number of malarial cases seems to be increasing due to drug resistant strains that are emerging, increased amount of travel and migration through…show more content…
However, the Qiagen Artus® Real Art is limited to laboratories that have the ability to run the PCR technique. Clinical Application Malaria can cause serious medical emergency, if not diagnosed could be fatal, furthermore, earlier diagnosis and treatment is crucial in patient survival. The need for simple and accurate testing for Plasmodium species will lower the number of untreated malaria patients and decrease the mortality rate of the patients in endemic areas. Notably, other deadly diseases have similar symptoms of malaria, making clinical diagnosis based off symptoms difficult (Tangpukdee, Duangdee, Wilairatana, & Krudsood, 2009, p. 94). In addition, the transmission of malaria has increased in endemic areas where malaria control has decreased allowing the emergence of drug resistant malaria species (Tangpukdee, Duangdee, Wilairatana, & Krudsood, 2009, p. 93). Differentiation between Plasmodium sp. is critical in determining the best treatment for the patient in particular Plasmodium falciparum and P. knowlesi have a fast onset of symptoms can lead to death while the other Plasmodium species are less severe and require different treatment (Centers for Disease Control, 2013, p. 2-3). Thick and Thin Blood Smear Microscopy The current gold standard in diagnosing malaria is microscopy, changing very little since its discovery. Regardless, after staining, the thick and thin blood smears a technician will use a microscope to detect and identify
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