A Research Study On Preterm Birth

1695 Words Nov 23rd, 2015 7 Pages
Preterm birth (PTB) is a worldwide problem defined as birth before 37 weeks of pregnancy. Many studies have associated preterm birth with cerebral palsy, epilepsy, sepsis, necrotizing enterocolitis, as well as respiratory, vision, hearing, and cognitive problems (Platt). Being born too early leads to a lower birth weight (LBW), which is the main determinant of newborn survival. Increasing infant complications are seen as birth weight and gestation age decline (Bansal). According to evidence, bacterial infections during pregnancy stimulate pro-inflammatory signaling cascades and cytokines. These pro-inflammatory cytokines in-turn activate neutrophils and promote prostaglandin production in order to cause contractions and weaken the fetus, therefore causing preterm birth (Park). All bacterial infections induce an inflammatory cascade and it’s important that researchers fully understand their relationship with pregnancy. The dental infection known as chronic periodontitis is one of the most common causes of inflammation in adults. Chronis periodontitis is induced by the gram-negative bacterium Porphyromonas gingivalis and is reported to affect over half of the United States’ population (Grenier). The article “Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice” reports a series of experiments and tests done to discover the relationship between chronic periodontitis and preterm birth.
In the following experiments from “Dental Infection of Porphyromonas…
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