A Research Study On Transplant Immunology

1834 WordsApr 24, 20178 Pages
Jennifer Wereski The number corresponds to slide number. 1. Hi I am Jennifer Wereski and I am going to talk about transplant immunology specifically heart transplants especially with the case study. Initially I will discuss statistics with general transplants and then UNOS and how they are listed and how that occurs. Then I will move into different types of rejections and medications for transplants. Then I will talk about the case study and future research. 2. I got this information from the US Department of Health and Human services. The most recent statistics that were available are from 2015. There are over 119,000 on waiting lists for different types of transplants. 30,970 transplants were performed in 2015. 22people die each day…show more content…
4. Genes that contribute to rejection are major histocompatibility complexes. These are found in all mammals. HLA- Human leukocyte antigens are found in humans. There are two major classes of HLA antigens. Class one is HLA A, B, C and class two is found on immune cells and they are DQ DP and DR. They are very polymorphic and everyone carries a wide range of HLA proteins. There is actually a less than 5% chance that unrelated individuals find an identical match. These HLA antigens can appear foreign to recipients’ immune system and this can trigger a rejection. 5. HLA cross matching is when a recipients’ blood is tested for HLA typing and listed in UNOS registry. This allow for better matching between donors and recipients. Sometimes HLA matching is not always used in heart, lung, and liver transplants and this is due to the critical state these patients are in. HLA matching is used in kidney and stem cell transplants when more accurate HLA matching is needed for long term survival. There was systematic review and meta-analysis done by Ansarai, Bucin, and Nilsson (2014) that looked at studies on HLA matching in heart transplants. What they found is there was an increased graft survival and decreased rate of rejection. However, there was not a lot of RCTs. This was a major limitation. They did recommend using class two alleles. They appear to have a better benefit rather than
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