A Review On The Viral Polymerase Inhibitor 7 Deaza 2

First isolated from a rhesus monkey in Uganda, the Zika virus (ZIK V) did not pose a serious global threat until recent outbreaks in 2007 on Yap Island in Micronesia and the current outbreak which began in 2013 in the French Polynesia. And, although the virus is transmitted via infected mosquitoes, studies indicate that the disease potentially can be transmitted sexually (Musso, D., Roche, C., Robin, E., Nhan, T., Teissier, A., and

Zika virus was discovered by scientists in the Zika rainforest in a remote part of Uganda in 1947, in the serum of an infected rheseus monkey. With five thousand two hundred thirty- four known cases of the infectious virus documented in the United States. There is currently no vaccination for the flu like virus. The chief concern of the healthcare administration is to continue to take preventive measures to prevent contracting the virus. Within the same flavivirus family

As of now, there is no official vaccine for Zika. Instead, a patient that has the contagion must undergo certain treatments. Fortunately, the remedies for the virus are simple and cheap. If infection occurs, it is vital to get an abundance of rest and liquids; medication is also advised to assist in alleviating pain. The treatments for Zika are straightforward because the disease itself is rather mild. In fact, in most reported cases of the virus in the United States, the illness only lasted approximately two to seven days prior to the first set of symptoms (“World Health Organization”). It is evident that the fear associated with the Zika Virus is slightly exaggerated. Currently, there is only one recorded fatality in the United States that is directly related to Zika (“The Washington Post”). This is mainly because first world countries’ medical programs are advanced enough to effectively treat the virus. The standard of living in these countries are also higher compared to third world countries. That is why Zika has claimed a significant amount of lives worldwide; the poor conditions in these countries make it difficult for infected individuals to get proper

This article focuses on the outbreak of the Zika virus, which has recently begun spreading across the world with an emphasis on Latin American countries Brazil and Colombia. There are currently over 26,000 people who have been confirmed as infected with the virus in Colombia alone and this number is expected to rise dramatically to about 600,000 within the coming months considering the location and altitude of the countries and the frequency of their carrier mosquito. The virus has no vaccine yet; all prevention methods are focused on controlling the mosquitos spreading the disease by promoting proper sanitation regarding dirty water storage and accumulated trash. Among the people infected is 16-year-old Angie Paola Castro, one of 3,177 women

In the recent article, “Zika outbreak: What you need to know” by the BBC, the World Health Organization released valuable information regarding how to detect the disease, and what steps you can take to prevent it. Some of the common symptoms of Zika are; mild fever, red and sore eyes, headaches, joint pain, and rashes. Death from Zika is rare, but a very uncommon disorder can be caused by Zika called Guillain-Barré syndrome. This disorder will cause temporary paralysis. As of now, there are no drugs or vaccines that will help prevent Zika, but those who have the disease should rest and drink plenty of water. The largest concern regarding Zika is the impact it has on fetuses still developing in the womb. Zika can cause another serious disorder

The Zika virus has had a constant presence in the news for the past few months. This article describes Ana Gabriela do Prado Paschoal's struggles. She contracted the Zika virus while pregnant with her now three month old daughter Maria. Maria now suffers from brain lesions, stiff muscles, and brain damage. With the help of scans, imaging, and autopsies doctors learned that the Zika virus eats away at the fetal brain. It is responsible for shrinking or destroying the part of the brain that controls vision, thought process, and other basic functions.

A particular stain of the Zika Virus, PRVABC59, has recently become an epidemic in South America and the Pacific¹, and in the last month has spread to Florida. PRVABC59 is a Flavivirus, ssRNA(+), is spread by Aedes Aegypti and Aedes Albopictus mosquitoes and is capable of spreading from mother to unborn child during pregnancy. Although the Zika virus normally doesn’t cause severe symptoms, further complications arise if a fetus is infected, as stated by the World Health Organization “There is scientific consensus that Zika virus is a cause of microcephaly and Guillain-Barré syndrome”. Before more research can be done to develop a vaccine or treatment, a specific primary antibody must be created as a tool for further research about the function of the ten proteins in the Zika genome. This project worked on nine of these proteins in ten parts. Two structural proteins, capsid and pre-membrane protein, and the seven non-structural proteins, with NS5 being split into two pieces due to its size and toxicity. A previous method of protein production and purification2 was followed to create these antibodies. This method of protein production and purification should lead to a primary antibody specific to recombinant proteins of the PRVABC59 strain of Zika virus, which is a necessary tool for further research into the PRVABC59 strain.

February 1, 2016 the World Health announced a PHEIC (Public Health Emergency of International Concern) that declared the Zika virus was a global health emergency. Brazil being the most affected country in the world right now has cases where pregnant women with the virus have given birth to children with smaller heads causing their brains to not develop correctly.The Zika virus is a flavivirus (Karimi) that is related to the common dengue virus and West Nile disease. A flavivirus is a group of RNA (a ribonucleic acid), that are mostly carried by mosquitoes, flies, fleas, etc. The virus carried causes severe human diseases, that are most commonly related to the Dengue and West Nile disease. The disease

a) With ZIKA increasing drastically in the past years there has been a push to find a vaccine that can protect individuals from contracting the disease and thus preventing the spread of the disease globally and sexually. The scientists in this study aim to find a treatment that will lessen affects of the disease and prevent transmission through treatment with Chloroquine. Cloroquine is known to treat malaria and parasitic infections already. Thus they tested the affects of Chloriquine on two strains of ZIKA in various cell types.

The Zika virus has affected the world in many ways. It is killing most of the population of the world in diffrent countries, including the U.S.A. the virus has done bad things to this world and scientist are trying to put a stop to this virus. The virus has been know for 50 years but the reason why we are hearing about it know is because of the summer olympics in brazil where the virus is mostly now. The virus could affect some of the athletes competing in the summer olympics this year. The virus is spreading quickly through misquotes.

A multidisciplinary team from the University of Texas Medical Branch at Galveston is the first in the world to engineer a clone of Zika virus strain. The findings were published in a study on Monday. This development can expedite many aspects of Zika research including

The Zika virus is very well known around the world as a mosquito carried virus that may cause birth defects to unborn children if pregnant women are infected. Since the Zika virus started spreading widely sometime in 2013, there has been many efforts to regulate the virus with a vaccine to prevent any harm to pregnant women and their unborn children. In the article, “Considerations for Developing a Zika Virus” written by Hilary Marston, provides useful information about what should be considered when developing a Zika vaccine in order to be successful and to eliminate any risk to pregnant women. Marston has stated her idea that, “An efficient development pathway must be delineated, including the optimal ways to evaluate the safety, immunogenicity, and effectiveness of vaccine candidates for intended target populations.” When creating a vaccine, Marston states that the

Neural progenitor cells are permissive of Zika virus (ZIKV) infection in humans, and the ZIKV’s ability to infect such cells is a major global concern, because no other virus from the Flaviviridae family can infect brain cells. AXL was identified as the virus’s mediator for entry and disruption of radial glial cells and endothelial cells of the brain. To analyze the virus- host interaction, specifically the reprograming of the host proteins directed by AXL after Zika entry, the study of the effect of ZIKV infection on the epigenome in mouse radial glial cells is to be performed. To visualize the epigenetic changes caused by the virus the mapping of the epigenome of both infected and mock RGC cells is done. Whole ZIKV-infected E17.5 fetal brains

Zika virus (ZIKV), a Flaviviridae family member is an arbovirus transmitted to humans by mosquitoes of the species Aedes aegypti. ZIKV epidemic over the past few years has implicated a rapid incline in neonatal microcephaly and Guillain Barre syndrome has become an immense global health issue. Like other Flavivirus, ZIKV has an enveloped, single positive sense RNA genome. The ZIKV glycosylated non- structural protein-1 (NS1) is known to be the main conserved feature among flavivirus, which interferes with host molecules and is vital in viral replication as well host immune modulation and pathogenesis. However, compared to typical flaviviruses such as dengue virus (DENV) and West Nile virus ,ZIKV NS1 demonstrates independent coding sequence

Due to the uncertainty of links between Zika virus and microcephaly as well as a dearth of knowledge on how the virus produces this teratogenic outcome, this essay has been written with a thesis statement that is that these occurrences are not a mere coincidence but that Zika virus is indeed responsible for the occurrence of microcephaly in foetuses. To achieve this, this paper will highlight results of a research carried out