A Short Note On Beta Thalassemia And Its Effects On African Descent

1337 WordsNov 2, 20156 Pages
BETA THALASSAEAMIA Beta-thalassemia is known as one of the most common autosomal recessive disorders around the world (Coa et al, 2010). This condition is seen the most in populations of Central Asia, Mediterranean, Far East Indian subcontinent and populations of African descent. When it comes to the highest incidence, the island of Sardinia in Italy (12%), Cyprus (14%) and South East Asia are amongst the highest (Coa et al, 2010). Population, which have high gene frequency of beta- thalassemia, are closely related to the high selective pressure of the parasite Plasmodium, this is because its distribution is quite similar to that of past or even present malaria endemia. Studies have also showed that carriers of Beta-Thalassemia are somehow immune to Plasmodium falciparum (Rachmilewitz et al, 2001). The condition of Beta-thalassemia is characterised by the reduction of beta+ or absence of beta0 of the beta globin chains (Shawky et al, 2012). In beta-thalassemia, there are three major clinical conditions recognised which are ; beta-thalassemia carrier, beta-thalassemia intermediate and beta-thalassemia major of which carrier being the mildest and major being the more severe condition. The severity of this condition is characterised by the extent of imbalance between the alpha globin and the non-alpha globin chain (Cao et al, 2010). CLINCAL FETURES OF BETA-THALLASSAEMIA BETA- THALLASSEAMIA MAJOR If patients with Beta-Thalassemia are homozygotes, they could either

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