A Short Note On Receptor And Its Effect On The Body

2152 WordsDec 10, 20169 Pages
Introduction CD36, which stands for cluster of differentiation 36 and is also known as SR-B2 (scavenger receptor b2), is a transmembrane protein that is part of the class b scavenger receptors. This is a protein that has many functions throughout the body. CD36 is typically involved in the binding of lipid-related ligands like oxidized LDL particles, long-chain fatty acids, collagens, thrombospondin-I, and others. With its versatility, CD36 can elicit a large variety of responses in the body such as different immune responses, waste removal, angiogenesis regulation, roles in taste reception etc. CD36 is also important to skeletal and cardiac muscle because it plays a key role in the utilization of long chain fatty acids which is used in the formation of energy (Luiken, JJ. 2016). Deletion or reduction of CD36 can cause a myriad of issues in an organism, whether that is a mouse or a human because of its role in dietary lipid use. In mice, there was reduction in the uptake of long-chain fatty acids by different types of muscle (cardiac, skeletal), a loss of preference for foods high in lipids, and a decrease in orosensory-mediated responses in digestive secretions. In humans, CD36 gene variants are susceptible to many issues such as abnormalities in lipid and glucose metabolism, metabolic syndrome, and diabetes-associated coronary disease (Tran, TTT. 2011). CD36 is a transmembrane protein that consists of two membrane-spanning regions surrounding a larger loop on the
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