A Short Note On Round Cell Tumor ( Dsrct )

Clear Cell Sarcoma is a rare type of cancer that usually affects young adults between the ages of 20 to 40 years old, not to be confused with Clear cell sarcoma in the kidney. Clear cell sarcoma is a genetic mutation, in chromosomal translocation, the two pieces of chromosomes are switched, which results in abnormal fusion of genes. When this happens, the clear cell sarcoma tumor

Rhabdomyosarcoma is the most common soft tissue sarcoma in children. It makes up a little more than 3% of childhood

According to the American Cancer Society, sarcomas are cancers that develop from connective tissues in the body, such as muscles, fat, bones, the linings of joints, or blood vessels. Rhabdomyosarcoma (RMS) is a cancer made up of cells that normally develop into skeletal muscles.

Eosinophilic granular bodies or Rosenthal fibers are not observed within the tumor, a feature that helps distinguish it from pilocytic astrocytomas. Psammomatous calcifications and pseudoinclusions observed in meningioma have not been reported in pituicytomas prior to this case. The nuclei of pituicytomas are bland with a small nucleoli contrasting with the salt and pepper chromatin seen in pituitary adenomas, particularly prolactinomas (20). Macroscopically, pituicytomas are firm, rubbery, circumscribed masses that may be adherent to adjacent structures contrasting with pituitary adenomas which usually have a softer consistency with numerous cells exfoliating on touch preparation (20). Granular cell tumors are composed of polygonal to spindle cells with small eccentric nuclei with inconspicuous nucleoli, PAS-positive diastase resistant eosinophilic granular cytoplasm and occasional perivascular lymphocyte aggregates. Pituicytoma must also be differentiated from normal infundibulum which has looser texture, perivascular fibrillar zones, is rich in axons and has occasional PAS positive herring bodies. However, the present case illustrates that uncommon histomorphologic features including dilated epithelial cysts, striking papillary formations and psammomatous calcifications can be observed within this rare

Most nephroblastomas are on one side of the body only and are found on both sides in less than 5% of cases, although patients with Denys-Drash syndrome mostly have bilateral or multiple tumors. They tend to be encapsulated and vascularized tumors that do not cross the midline of the abdomen. In cases of metastasis it is usually to the lung. A rupture of Wilms tumor puts the patient at risk of bleeding and peritoneal dissemination of the tumor. In such cases, surgical intervention by a surgeon who is experienced in the removal of such a fragile tumor is imperative. Pathologically, a triphasic nephroblastoma comprises three elements: Blastema, mesenchyme, and the epithelium

site, tumor size, and mitotic frequency. We report a case of multiple malignant GIST with

Ewing’s sarcoma (ES), a malignant osteolytic tumor, characterized as small round cell tumors was first documented by James Ewing in the year 1921 as diffuse endothelioma of bone. Rarely, it also has extra osseous manifestations which resembles intraosseous ES. This extra osseous forms of ES was first described by Tefft in 1969.(1) Ewing’s sarcoma (ES) family of tumors include: classical ES (osseous origin), atypical ES (extra osseous), Primitive neuroectodermal tumor (PNET) and Askin tumor[2] . All these tumors have common morphology, immunophenotypic features and cytogenetics, hence included in the same family of tumors. These tumors were believed to be derived from a primitive cell. The primitive cell can be either the neural crest or mesenchymal

When the doctor says to the patient that he has a tumor the first question comes to his mind if it is malignant or benign, but there is an important information that people do not know. Malignant and benign tumors have similar characteristics. First of all, a benign tumor can become a huge mass. Similarly, a malignant tumor has different sizes. For example, since scientists discovered the disease until these days they have been removed billions of masses weighing over a hundred pounds of malignant and benign tumors. In 2012, a Vietnamese man underwent a 12-hour operation to remove a 200-pound tumor from his leg. Nevertheless, it depends on how fast the cells are separating. Like the malignant tumor, benign tumor can be treated. For instance,

Ewing’s sarcoma is a rare bone cancer.1-3 Ewing’s sarcoma is from the Ewing’s family of tumors.1-9 There are three types of Ewing tumors in bone and they include a classic Ewing’s sarcoma, a primitive neuroectodermal tumor or PNET, and Askin tumor which is a PNET of the chest wall. Ewing’s sarcoma is the second most common malignant bone tumor in children and adolescents. It accounts for 2% of all childhood cancers.1-3 Ewing’s sarcoma accounts for approximately 10-15% of all primary bone tumors.2 It is slightly more common in males than females. The ratio has been described as 2:1 and 1.5:1.1-4 It was first discovered in 1921 by James Ewing.1,5 Ewing’s sarcoma is more common in Caucasians. It was described as a “diffuse endothelioma of bone” by Ewing.4 Ewing’s sarcoma can affect any bone. The most common sites are the lower extremities and pelvis.1-4 Tumors can occur in bone or soft tissue (extraosseous). This paper will discuss the causes, the signs and symptoms, diagnosis, treatment and prognosis of the disease.

In some cases, the tumor does occur randomly with no association to genetics or other existing health conditions. These forms are described as sporadic and generally don’t spread to other parts of the body, unlike an aggressive fibromatosis condition also referred to as desmoid tumors outside the abdomen.

The anterior mediastinum is the most common site of mediastinal tumors in children. Those tumors mostly arise from the thymus and prevascular lymph nodes. Lymphoma, germ cell tumor, thymoma, and lymphatic malformation account for all anterior mediastinal masses.

Testicular cancer is when their is an abnormal growth in the testicas from malignant cells. Cancer in the testicals is very rare since it not hereditary, and it is very curable when found in its early stages (source,year)., Iit is mostly only cause by when germ cells (sperm cells) mutate in such a way that it causes cancer (1). With testicular cancer there is 1/263 ca]hance that males will get testicular cancer, but there is a 1/5000 chance from dieing dying from testicular cancer (2). There are two most common forms of tesicular cancer in males, seminoma cancer and nonseminoma. Seminoma testicular cancer is slow growing and will often not migrate far from its original location. Nonseminoma testicular cancer is fast growing and spreads more quickly unlike Seminoma. With testicular cancer males will often have an abnormal lump in the socrum, a feeling of added weight to the socrum, or even some slight pain as well. (3)

The information from this report is useful because there’s an in depth review of what goes into classifying a tumor, and what limitations, or benefits are present based on the histological, physiological, and immunocytochemical appearances and methods.

A biopsy is essential to confirm the diagnosis. On microscopic examination, the tumor demonstrates peculiar features of expohytic papillary growth consisting of atypical cells and fibrovascular core. These atypical squamous epithelial cells showed the characteristics of hyperchromatism, nuclear atypia, cancer pearls, apoptotic bodies, nuclear atypia and individual keratinization. Mild stromal invasion was noticed.

Bilateral Wilms Tumor (BWT) is one the most uncommon manifestation of Wilms Tumor. In this paper, we present a 2-year-old boy who came to hospital because of an enlarging mass in left abdomen since 1.5 years ago. This patient was then diagnosed as BWT with WAGR syndrome and underwent chemotherapy, nephrectomy and orchidectomy. Patient did well in this treatment. In this paper, we present a case report, along with literature review on stage V Wilms Tumor.