A Short Note On What It Is?

the secretion of hydrogen ions, which leads to the acidification of the urine, because of

The amino acids that are not immediately required are broken down in the liver to make urea; this urea is carried in the bloodstream to the kidneys for elimination of waste.

Gout is a hereditary disorder that occurs more frequently in men, than women. An excess of uric acid in the blood and tissues causes it. The pain is caused by crystals of acid formed under the skin and in the joints. Gout occurs when there is too little uric acid excreted or too much for the kidneys to excrete. An attack begins suddenly with severe pain

Osteoarthritis and gout are both a chronic disease. There is no cure, but symptoms can be treated. When taking an x-ray, it important to take a medical history from the patient. It can be helpful in treatment of the patient. X-rays can show damage and other changes related to osteoarthritis to confirm the diagnosis. Doctor or physician most probably looking for areas that are tender, painful or swollen as well as any signs of joint damage. The treatment of osteoarthritis and gout include maintaining a healthy weight, a physical activity daily, and taking a medications. There are techniques to improve flexibility, stiffness and pain by slowly and gently stretching of joints without hurting a patient. Chronic gout can be treated with over-the-counter drugs. There are several medications are available to reduce uric acid levels. Drinking plenty of water or other fluids helps to remove toxic substance such as uric acid from the system and reduce further

Gout is classified as the “buildup of uric acid crystals in the joints… [that occur as a result to] many [of the] foods we eat” (WebMD). These needle-like crystals are what contribute to the sudden pain and swelling of a gout attack. My father’s doctors reported that not only did he have gout, but that if he stayed

Many areas incorporate chemicals referred to as purines, which in turn separate typically for making uric damaging. Almost all blood-borne uric damaging is going harmlessly through the kidneys, the actual FDA explained, nonetheless an overabundance on the damaging can easily induce the action program regarding uric jewels, which in turn go up to obtain gout.

There are links between high serum urate, hyperuricemia, and many inflammatory diseases, yet the mechanism is obscure. For humans, purine and ATP are broken down to urate, which builds up in plasma because we lack the enzyme uricase to promote its excretion as allantoin. Urate may benefit our health by acting as an antioxidant that scavenges reactive oxygen species. Yet, hyperuricemia is associated with gout, metabolic syndrome and cardiovascular disease. These inflammatory diseases are characterized by inflammation and oxidative stress. During oxidative stress urate is oxidized to several reactive electrophiles including urate hydroperoxide. This novel oxidant could promote the pro-oxidant effects of urate.

Gout is a common disease that is composed of a metabolic defect in the breakdown and excretion of uric acid. This excess of uric acid is what causes gouty arthritis. Uric acid crystallizes due to the improper breakdown of

Gout is the most common form of inflammatory arthritis, resulting from the deposition of monosodium urate crystals in and around the joints as a results of chronic hyperuricemia. In the United States 3.9% of adults (8.3 million Individuals) suffer from gout. The gout flare up is a self limiting condition, that if left untreated or is not well managed may lead to chronic recurrent flare ups (Tophi), causing chronic disability and impairment of health related quality of life.

Gout is a complex metabolic disease that presents itself in a form of arthritis that causes unexpected, severe attacks of pain. In addition, men are more likely to get gout, but women become increasingly susceptible to gout after menopause (Mayo Clinic Staff, n.d.). Generally, gout affects one joint at a time and causes tenderness, redness, warmth, and swelling of the joint. However, it can be in several joints. The big toe is most often affected, but gout can also affect other joints in the leg – such as the knee, ankle and foot – and less often, the hand, wrist, fingers and elbow ("Arthritis and Gout," n.d.). An attack of gout can occur suddenly, often waking you up in the middle of the night with the sensation that the big toe is on fire. In fact, the joint is so tender that the mere weight of the sheet upon the affected joint may seem intolerable. The prevalence of gout appears to be increasing. It is currently estimated to affect over 6 million Americans (Shiel, Jr., M.D., FACP, FACR, 2015).

The treatment of gout is usually conducted over two separate phases: in cases of acute gout, rapid relief is offered from joint pain and inflammation, while in chronic cases, long-term management is provided to reduce serum urate, thus decreasing further acute attacks and irreversible joint damage (Moi et al., 2014). The European League Against Rheumatism (EULAR) management recommendations include lowering serum urate below 360 μmol/l (6 mg/dl). This has been

Gouty arthritis, hypertension, hyperlipidemia and left ventricular hypertrophy are the main diagnosis. American College of Rheumatology diagnostic criteria for gout is the presence of urate crystals in the joint fluid (Hainer et al., 2014). Monosodium urate crystals are seen under a polarizing light microscope which confirms the diagnosis of gout. Furthermore, the most commonly affected area is the first metatarsophalangeal joint. Other common sites are mid-tarsal joints, ankles, knees, fingers, wrists and elbows. Also, gout appears to be red and swellon in the affected joint (Saccamano, 2015). Similarly, patient had left knee pain with redness and swelling. Hypertension is diagnosed by the systolic blood pressure ≥ 140mmg Hg or the diastolic

Gout is a kind of athritis that most common in middle aged men, but is know to effect women usaully after menopause. Gout is caused when your body produces or intakes too much uric acid. High levels of uric acid do not cuase Gout immediately, it’s the crystalzation of the acid that causes the diesse. Gouts symptons are very similar to inflamatory arthritis, causing pain in joints around your body but primarly below the waist. In almost all cases of Gout the effected person feels pain at the base of their big toe. The symptons are described as recurrent attacks of athritis cuasing red, hot, tender and swollen joints. Pain is quick to appear typically taking less than 12 hours to reach its peak, and

According to Rosdahl (2010), "The body produces substances called purines during metabolism. If the body is unable to metabolize these substances, uric acid accumulates in the bloodstream and forms crystal deposits in the joints" (p.1236). This arthritic condition called gout is a condition of hyperuricemia wherein these uric acid accumulates and form hard crystals deposited in your joints. It can harm your joints, tendons, and other tissues. It can cause an attack of sudden blistering joint pain, stiffness, and joint swelling. It often affects the joints of the big toe, instep, ankle or knee but it may appear in any joint.

Recurrent severe attacks of gout and the development of tophi can cause permanent damage to the joints.  Joint replacement surgery may be required to restore joint function.  *