A Study Of Adhesion And The Entry Of Magnetite Nanoparticles

Ricardo Morales on the synthesis and characterization of bimetallic magnetic nanoparticles for further application in cancer treatment, I gained the skill sets needed to come up with research ideas and implement them as well as how to resolve issues that arise within any research. My experience as a teaching assistant in organic and general chemistry at the University of La Verne Chemistry Department taught me the importance of lab safety and the joys of connecting what is learned in lecture to lab and helping students make that connection in a lab setting while creating a safe environment. My experience as an Academic Success Center tutor in chemistry course from general chemistry to advance organic chemistry taught me the joys of helping students to truly understand material and not memorize it but have that knowledge become a part of them that they can use whether in a research setting or to explain those concepts to their peers. These experiences in undergrad allowed me to determine that academia was the right fit for me; graduate school will give the skills needed to fulfill this

Using of spinel ferrites nanoparticles in electromagnetic devices such as memories, sensors and data storage in modern information technology applications [1-3] made many researchers all over the world do all efforts for synthesis and development of magnetic nano-particles. These nano-particles possess special magnetic and electrical properties with high

Béalle and collaborators (2014) described the use of superparamagnetic iron oxide nanoparticles (ɣ-Fe2O3) to decorate catanionic vesicles. The vesicles were prepared by using cetyltrimethylammonium chloride and myristic acid and the nanomaterial was synthetized in aqueous alkaline solution by co-precipitation process of FeCl2 and FeCl3. The decoration and incorporation of ɣ-Fe2O3 was carried out by an adsorptive process onto the vesicles structure [7]. Additionally, silica-coated unilamellar surfactant vesicles was prepared by hydrolysis and condensation of silicon alkoxides [8] into organized inorganic material (Dioctadecyldimethylammonium bromide and didodecyldimethylammonium

Nanotechnology has immense numbers of avenues and directions that have been created, especially in the treatment of cancer. It is only projected to become a bigger field that’s more accurate as time passes. But is nanotechnology sustainable and though accurate, strong enough to be the best cancer therapy system? Is lung cancer too difficult to treat with nanotechnology due to its metastatic tendency? And is nanotechnology the best direction that we could be following in our quest for the treatment of cancer without damaging other tissues? As we discover more technology and tools, problems pop up as quick as we can solve past ones – toxicological aspects of cancer treatment, cost effectiveness and the like. Can these wonder child molecules created

While it seems like this burgeoning field has only recently blossomed, its roots date back as far as 1869, with the first reported description of CTCs by Thomas Ashworth (Ashworth, 1869). After a sparse trail of publications, early reports on methods for detecting CTCs via filtration (Salgado et al., 1959) and sedimentation (Alexander and Spriggs, 1960) emerged nearly 100 years later. Perhaps the most commonly used technique for detection today, immunomagnetic separation, was not reported until 1998 (Racila et al., 1998). In addition to introducing a new detection method, Racila et al. also demonstrated that CTCs exist early in disease and correlate with disease progression e providing a new perspective on the potential role of CTCs in modern cancer research and therapy. Today, researchers look to profiling components, including CTCs, in serial blood draws (liquid biopsy) to transform the current landscape of cancer therapy by i) determining patient prognosis, ii) monitoring tumor recurrence and therapeutic responses in real-time, iii) identifying new therapeutic targets, iv) elucidating drug resistance mechanisms, and v) improving our current understanding of tumor progression and metastatic disease. Multiple studies have demonstrated that elevated CTC counts indicate a poor prognosis for metastatic breast, prostate, colorectal, and lung cancer patients (Cristofanilli et al., 2005; Smerage et al., 2014; de Bono et al., 2008; Cohen et al., 2008; Miller et al., 2010; Krebs et al.,

The efficient delivery of drugs and energy to tumors faces several difficulties and obstacles that need to be overcome for effective cancer treatment. Nanoparticles administrated through intravenous injections accumulate at a tumor site due to the enhanced permeability and retention (EPR) effect, but only a small quantity of the injected particles can actually “reach the tumor” (Su et al, 2016). The majority of the nanoparticles interact with “cancer cells at the periphery of a tumor” which presents a “physiological barrier” that prevents most of the injected particles from reaching the tumor (Su et al, 2016). In addition to this barrier, there is also another significant obstacle, “cancer-associated fibroblasts”, which can also

Breast cancer treatment and therapy with nanomedicine is a fad nowadays and rightfully so, it is the need of the minute. The incidence rate of breast cancer has witnessed a minimum 10-fold increase in the past few decades. The mortality rate in women is rising and breast cancer is a major contributing factor. Due to several changes in the hormonal, nutritional and environmental factors over the years, there is a shift observed in the rise of breast cancer. At a point, conventional mammography for detection and early treatment was the focal point but with the advent of research methodologies, nanomedicine has come into play. The scientific world is encouraged to develop methods that utilize nanoparticles for targeting the vicious breast cancer tumors. The cardinal reason for the preference of nanoparticles is its minute size and structure. In addition, the surge in the demand is also due to the much-favoured ability of the nano particulates for the therapeutic delivery of the drug and the reduced cytotoxic effects to the surrounding tissues. This, along with the former characterisitic, invariably leads to the increase in demand of the nanoparticles.

In many of the above studies easy entry of the nanoparticles was facilitated either by leaky BBB in the case of brain tumor or by the effect of TAT peptides, lactoferrin etc conjugated to the nanoparticles. 2c-j Herein we report the use of gold cluster of very small size to target the brain, in the early stages of disease, when the barrier is not much distorted.

I first felt thrilled in pursuing scientific research, when I learned about critical aspect of materials chemistry in the elucidation of nanoparticles for drug delivery systems in organic chemistry with Prof. Sunasee. Since then, I host a passion for academic and research traing designed to prepare me for graduate studies in the development of nanomaterials and nanotechnologies for healthcare. My primary research interests are in the fields of nanotechnology and materials chemistry for drug therapy and cancer biology (of the p53 and pro-apoptotic signal transduction pathways).

Nanotechnology has become something of a buzzword in recent times. This is primarily due to it being a new and emerging science, but also because of its amazing applications and uses. Nanotechnology encompasses a varied array of subcategories in chemistry, biology, and physics. Generally, it includes all particles which are on the order of 1 billionth of a meter. [1]. As the particles involved are this small, it allows a variety of new technologies as well as new options for the treatment of diseases. Cancer is but one of these few diseases which nanotechnology has presented a new and refreshing chance to find a treatment. Cancer can be defined by anomalous and invasive

The encapsulation and site-directed mechanisms can also be translated and utilized in bioimaging – the field of study concerned with developing imaging techniques and devices that are used to obtain anatomical images and provide tissue analysis. Medical professionals are always looking for answers as to what is going on inside one’s body. Nanoparticles can serve as excellent scaffolds in this area of research because they have such a high surface area- to- volume ratio [9]. Ferritin, in particular, has been modified in different ways, mainly using the techniques described earlier, to further advancements in this field.

The most clinically effective treatments for cancer were ironically incredibly detrimental to the human body 's health. These included, chemotherapy and radiation. These two methods did in fact destroy the malignant cells yet also caused apoptosis in healthy cells damaging them beyond repair and thus causing a great detriment to the patients health. However, recently, due to the endeavours of nanotechnology, it has been discovered that carbon nanotubes can effectively carry anti cancer drugs destroying the malignant cancer cells without damaging the healthy cells, in other words, the

Since positively charged nanoparticles could easily uptake nucleic acids, we examined the possibility of using this new DDS to simultaneously deliver different chemotherapeutic drugs and siRNA targeting ABCG2. Our results demonstrated that both anti-tumor drugs and siRNA against ABCG2 were successfully delivered into CD133+ cancer cells of laryngeal carcinoma by loaded MSNs. Down regulation of ABCG2 significantly enhanced the efficacy of apoptosis induction by chemotherapeutic drugs in laryngeal carcinoma cells. Furthermore, the chemotherapeutic drug and siRNA loaded nanoparticles also inhibited tumor growth in vivo in a laryngeal cancer mouse model.

National Cancer Institute at the National Institutes of Health. “Benefits of Nanotechnology for Cancer.” NATIONAL CANCER INSTITUTE - CANCER.GOV, 8 Aug. 2017, www.cancer.gov/sites/ocnr/cancer-nanotechnology/benefits.

• Site-specific targeting can be achieved by attaching targeting ligands to surface of particlesor use of magnetic