A Study On Type 2 Diabetes Mellitus

Type II Diabetes, also known as diabetes mellitus, is also called non-insulin-dependent diabetes or aadult onset diabetes. It is a medical disorder that, due to a number of factors codependent with the modern world, is characterized by higher than normal blood glucose levels that play havoc with insulin deficiency and resistance. Insulin resistance means that cells do not respond appropriately when there is free insulin in the blood system. Essentially, they body is reacting to an improper balance of sugars and insulin. Because obesity is often present, research suggests that even thought the mechanisms controling glucose and insulin are unclear, the adopose tissue likely

This essay will focus on type 2 diabetes, which is becoming one of the fast growing chronic health conditions in the United Kingdom (UK). Approximately 700 people are diagnosed with type 2 diabetes each day in the UK (Diabetes Uk, (2014)a). It is costing the NHS about £10billion pounds each year to treat diabetes along with its complication and it is expected to rise in the next couple of years (Diabetes UK, (2014)b).

Diabetes mellitus (DM) is a pandemic that affects millions of people. The growth rate of unrecognized pre-diabetes in America is expected to rise up to 52% by 2020 (Lorenzo, 2013). As the prevalence of diabetes increases, so will the complications and burden of the disease. One of the leading causes for cardiovascular disease, renal failure, nontraumatic lower limb amputations, stroke, and new cases of blindness is DM (Lorenzo, 2013).

Type 2 diabetes mellitus (T2D) is the most common form of diabetes (American Diabetes Association, 2012). T2D is so prevalent that it is estimated to be the fifth most common cause of death worldwide (Yates, Jarvis, Troughton, and JaneDavies, 2009, p. 1). T2D manifests when the body is unable to metabolize glucose properly, resulting in elevated blood sugar, debilitating fatigue, and other serious complications such as distal limb amputations, kidney failure, and blindness. The generally accepted causes of T2D include diet, sedentary lifestyle, and obesity.

Type II diabetes mellitus (DM), also referred to as non-insulin dependent diabetes, is a relative, rather than absolute, deficiency of insulin (ADA, 2004). It is global problem and has been identified as one of the “most challenging contemporary threats to public health” (Schauer et al., 2012). One is at risk for developing type II diabetes if they are overweight, over the age of 45, have a relative with type II diabetes, are sedentary, gave birth to a baby over 9 pounds, or had gestational diabetes (Center for Disease Control and Prevention [CDC], 2016).

Diabetes has become a widespread epidemic, primarily because of the increasing prevalence and incidence of type 2 diabetes. Diabetes is an endocrine disease in which the body has either a shortage of insulin or a decrease ability to use insulin or both. Insulin is a hormone that allows glucose to enter the cells and be converted into energy. Diabetes can be characterized as a prevailing, incapacitating, and deadly disease. There are a number of risk factors that increase a person’s tendency toward developing type II diabetes. Modifiable risk factors include obesity, physical inactivity and poor dietary habits are just a few. The

Type 2 Diabetes Mellitus (T2DM) is a chronic disease that is modifiable and preventable through diet and exercise. The incidence of T2DM is propagated by a sedentary lifestyle and excessive caloric intake. Maintenance of a desirable body weight, diet, and exercise are the mainstay therapy for T2DM (Buttaro, Trybulski, Bailey, & Sanberg-Cook, 2013).

Diabetes type two is one of the fastest growing public health problems in the world. It is difficult to treat and expensive to manage. It has been estimated that the number of people with diabetes in the world will double from the current value of about 190 million to 325 million during the next 25 years (WHO, 2016). Individuals with type-2 diabetes are at a high risk of developing a wide range of complications such as cardiovascular disease, peripheral vascular disease, nephropathy, changes to the retina and blindness that can lead to disability and premature death (CDC, 2014). There is a genetic susceptibility and environmental influences for development of diabetes mellitus type 2, however, there is an increase of physical inactivity, obesity, and type-2 diabetes has been observed in the Western world. One of the major risk factors is obesity and physical inactivity may constitute the main reasons for the increasing burden of diabetes in the developed world (CDC, 2014). Type 2 diabetes mellitus most commonly occurs in adults age 40 years or older, and the prevalence of the disease increases with advancing age. The aging of the population is one reason that type 2 diabetes mellitus is becoming increasingly common. (CDC, 2012).

Type 2 diabetes is a very well known disease throughout the US. There are about 27 million people in the US with the disease and 86 million others have prediabetes which means their blood glucose is not right but also not high enough to be diabetes yet. 208,000 people under the age of twenty have been diagnosed with either Type 1 or 2 Diabetes.

Diabetes Mellitus Type II (DMT2): a chronic disease due to progressive insulin secretory defect on the background of insulin resistance diagnosed by A1C or plasma glucose criteria (ADA, 2015)

Type 2 diabetes mellitus is a challenging disease process. It requires much work on the behalf of the patient. Patients are required to monitor their glucose levels. Those that must monitor during work hour find it inconvenient. The change in diet is challenging as they must develop new eating habits. At my practicum, classes are offered to teach patients portion control, starch counting, and finding food substitutes. Along with diet, exercise is a key factor in controlling glucose. According to Lumb (2014), low to moderate activity is beneficial in reducing glucose levels. FNPs must meet the challenge of education and medication with diabetics. Patients must be educated about burden and benefits of glycemic control. Medication for

Diabetes is one the most critical medical issues of our time. According to the Center of Disease Control and Prevention nearly 26 million Americans (approximately 8% of all Americans) have diabetes and an estimated of 79 million adults are pre-diabetes. Approximately $200 billion per year is lost due to diabetes because of medical treatments and lost wages. Insulin resistance and the dysfunction of beta cells are the two pathogenic hallmarks of the development and progression of T2DM. Studies have shown that pancreatic beta cell functional mass is affected in T2DM (1, 2). Secretion of insulin stimulated by glucose is lower in human islets of Langerhans isolated from patients with T2DM than from normal individuals (1, 3). Knowledge of the molecular mechanism underlying defects in beta cell function found in humans and animal models of T2DM is incomplete. Without a more complete understanding of the mechanisms that regulate beta cell insulin secretion we will be unable to develop new approaches to prevent and treat diabetes.

Background and Significance: The prevalence of type II diabetes mellitus is increasing in the United States (U.S.) and was estimated to affect 29.1 million Americans in 2012. By the year 2050, it is estimated that one in three U.S. adults will have type II diabetes mellitus. Long-term complications of type II diabetes mellitus include increased morbidity and mortality as a result of macrovascular and microvascular complications such as diabetic nephropathy, retinopathy, neuropathy, and cardiovascular disease. Several factors including genetics, insulin resistance, and decreased β cell mass can lead to the development of type II diabetes mellitus. Nonetheless, interventions that target the early stages of its pathogenesis (i.e. pre-diabetes)

T2D is the most common type of diabetes where the body does not produce enough insulin to maintain normal blood glucose levels or the insulin produced does not work effectively. According to AHA (2015), “diabetes contributes to over 230,000 U.S deaths per year” (p.1), however, many people are not aware they have the disease as it usually develops slowly over time and may already have developed health complications associated with T2D. There are non-modifiable and modifiable risk factors for T2D.

Genetic factors and family history is a strong risk factor for T2D but lifestyle factors also play a significant role in preventing the development of the condition. Learning about