Abstract. Objectives: To Highlight The Importance Of Cord

1362 WordsFeb 28, 20176 Pages
Abstract Objectives: To highlight the importance of cord blood S100B protein in neonatal hypoxic-ischemic encephalopathy (HIE) Subjects and Methods: This study included 60 asphyxiated newborns and 40 matched controls. Blood samples were collected from all neonates and values of S100B protein were determined using enzyme-linked immunosorbent assay (ELISA) technique. Results: The mean serum level of S100B protein was significantly higher in asphyxiated group than the control group with a significant correlation between increased S100B protein level and severity of HIE among patients. We found that at the cutoff level of serum S100B protein 0.44µg/l, sensitivity 97%, specificity91%, an accuracy of predicting neonatal asphyxia 94% with…show more content…
In 1976 Sarnat and Sarnat carried out a score, the Sarnat score, which was a combination of neurological symptoms as described above and the accompanying electro-encephalographic (EEG) features. This score was, in fact, a grading of the severity of the encephalopathy. It contains three stages, hypoxic-ischemic encephalopathy (HIE) stage 1, HIE stage 2 and HIE stage 3, the latest the most severe stage of encephalopathy. The most severely affected infants typically progress from stage 1 to 3 [7,8]. The S100B protein is produced and released primarily by astrocytes in the CNS where it has trophic functions on neurons and the glia. Many molecules are asigned a role as markers of neurological injury in cases of HIE. Glutamate, aspartate, lactate, ammonia, creatinine, specific kinase, NSE (neuron specific enolase) and other substances have been studied in serum, umbilical cord blood, amniotic fluid and cerebrospinal fluid (CSF) [9]. Previous studies that measured the concentration of S100B in the CSF and blood have shown a direct relationship with brain injury [10]. The aim of this study was to highlight the importance of cord blood S100B protein in the diagnosis of neonatal HIE and determination of its severity. Patients and Methods This cross-sectional study is conducted on 60 asphyxiated full-term neonates delivered in El Shohadaa Central Hospital and Shebeen El Kom teaching Hospital in the period

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