Acetaminophen And Excedrin Synthesis Lab Report

The main goal of this lab was to determine which of the acetaminophen and acetylsalicylic acid exists in Anacin and which exists in Tylenol. In order to achieve this goal, Thin Layer Chromatography, an approach that uses the difference in the strength of intermolecular forces and polarity in molecules to separate mixtures, was used

The unknown sample was identified to contain Acetaminophen, Aspirin, and caffeine based on comparison of known Rf values (Table 1). When comparing the traveled UV lit spots (figure 1), Aspirin and Ibuprofen traveled the same distance from the start line. Unknown sample 16 contains Aspirin not Ibuprofen, due to the intensity of the spot under UV light. Aspirin and the unknown shared that same intensity, whereas Ibuprofen did not share that same strength of brightness. The distance traveled by the samples was dependent upon their affinity for the mobile phase 200:1 ethyl acetate – acetic acid. The samples that traveled the furthest like the Aspirin and Ibuprofen were the most soluble in the mobile phase. The samples that traveled the shortest

The aspirin was synthesized when it was placed in a cold bath. Purification was necessary to remove any unreacted salicylic acid and acetic anhydride as well as the acetic product and phosphoric acid. Acetic acid and phosphoric acid are water soluble so they were removed by

The goal of this experiment was to synthesize aspirin. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in the solution as well as some sulfuric acid, aspirin, and acetic acid. Crystallization, which uses the principle of

The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding Iron (III) chloride to the product.

In this experiment, several analgesics were analyzed by Thin Layer Chromatography (TLC) and the composition of an unknown tablet was identified. We define chromatography as the separation of two or more compounds or ions by their molecular interactions by either a moving or a stationary phase.1 There are different types of chromatography: Thin Layer Chromatography (TLC), Gas Liquid Chromatography (GC), and Column Chromatography (CC). All of which there two phases:

AIM: To extract codeine and paracetamol from its tablet by solvent extraction and tentatively identify in comparison to standards using Thin Layer Chromatography.

Based on the Rf value for unknown, aspirin, acetaminophen, ibuprofen, salicylamide, and caffeine were 0.2612, 0.2581, 0.0476, 0.5714, 0.3, 0.0714. The second hypothesis was like initial hypothesis that the possible components contain in the unknown drug were aspirin, and salicyamide, the possible drug was aspirin, but cannot for sure what the unknown was. Because the drug that contain salicylamide, but didn’t contain the caffeine component which didn’t show up in this case. The drugs list in the chart, none of the drug contains the component aspirin, and salicyamide at the same time. Based on the Rf value and the observation, the lab experiment wasn’t accurate and some error was occurred during the lab period.

In this experiment the synthesis of aspirin was used to find the importance of the efficiency of multistep synthesis as well as a means to explore a number or purity tests. The purity tests used in this experiment were a melting point range test, a thin layer chromatography test, a ferric chloride test, and infrared spectroscopy.

Acetaminophen (also known as Paracetamol) is an acylated aromatic amide and is an analgesic drug used as in many cold and flu medications [1]. At At therapeutic doses, Acetaminophen is metabolized to to paracetamol glucuronide and paracetamol sulfate, and are then excreted in the urine [10]. A minor component of APAP is also oxidized by the microsomal cytochrome P450 system, predominantly by Cyp2E1 and Cyp1A2 [11], to form a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI) [12]. This minor metabolite is typically harmless, since it is mostly conjugated with glutathione and excreted in bile [13,

As previously said, the experiment was about finding out chemical components in Tylenol and Anacin, the task was to find which of those compound contains acetaminophen and acetylsalicylic acid. Two tablet of Tylenol and Anacin were given and crushed in two different mortar and pestle in order to avoid cross contamination. When taking a sample of both compound out of mortar, two very clean spatula were used to put the powder in the test tube and then added 2.5 ml in each test tube of 50/50 mixture of ethanol and methylene chloride solvents. The mixture were stirred by using a clean glass rod for few minutes to get a well dissolved mixture. In addition to both solution already made, two more compounds were provided: acetaminophen and acetylsalicylic

Acetaminophen or Paracetamol (4'-hydroxyacetanilide, PAR) is used as an analgesic and antipyretic drug, which is used for mild to moderate pain. It is also useful for lowering fever [1]. It is a main ingredient in many cold and flu remedies. In combination with opioid pain drug, acetaminophen is used in the management of severe pain such as cancer pain and after surgery [2].

This lab report is based on the third experiment, and it was the Extraction: Separation and Purification Technique. The purpose of this third lab was for the lab students to understand about the process of extraction and how it can be used to separate substances. The lab students were given the mixture of the equal amounts of Aspirin (Acetyl Salicylic Acid), Acetanilide and Urea. The lab students would have to go through the process of extraction in order to separate the three compounds from each other. The goals of this the third lab was for the students to successfully separate the three compounds (Aspirin, Acetanilide, and Urea) from each other, figuring out the percent recovery and to determine the purity of the substances that were recovered.

Acetaminophen (N-acetyl-p-aminophenol, abbreviated as APAP) is one of the most widely used analgesic, antipyretic, and anti-inflammatory drugs worldwide [1]. While generally considered to be safe for humans at a maximum recommended daily dose of 4,000 milligrams (mg) per healthy adult [2], at higher concentrations this drug can cause serious adverse effects, especially toxicity to the gastrointestinal, renal, and hepatic systems [1]. Moreover, APAP poisoning, either by accidental or intentional overdose, is a frequent problem in current medical practice. For example, it is the paramount cause of acute liver failure in the Western Europe, the United States, Canada, and Australia [3]. Therefore, an extensive body of literature dealing with acetaminophen

The purpose of this lab was to calculate the mass percent of ASA in a tablet of aspirin. After conducting the experiment, the molarities of the each diluted ASA solution were calculated. Then, the slope of the Beer’s Law plot was determined by graphing the DS molarities and absorbances. That slope is then used to calculate the concentration of ASA in the diluted aspirin solutions. From the concentrations, the mass of ASA is then calculated; the average mass being 0.343 g. The average percent of ASA in the tablet is 92.7%. Most of the aspirin tablet consist of ASA. An error that could have came from pipetting the diluted solutions into the flasks. It is very easy to accidentally over pipet the amount needed. Once the solution goes into the volumetric