Adenosine Function In The Body

mediators, causing increasing capillary permeability and widespread fluid shift into the interstitial space, which was no longer functioning to maintain vascular volume (known as third spacing) in addition, causing further vasodilation to occur.

• Decreased SOB, decreased crackles in the bases of the lungs, and possibly decreased O2

White PJ & Nguyen TT. 2002. _Chronic Caffeine Treatment Causes Changes in Cardiac Adenosine Receptor Function in Rats_. 65,3, 129-135.

Melatonin is a hormone that makes us drowsy, it’s activated by the time of the day, light exposure, and many other things. The more melatonin in your body the sleepier you are going to be. But an important part of your sleeping process is adenosine. Adenosine is released periodically hour by hour building in your system. And when you go to sleep adenosine breaks down and begins the whole process again in the morning. Now the reason adenosine is so special is because it’s a neuro-depressant. When it attaches to your receptors, it slows down neuron activity which makes you more sluggish and tired over the day. It naturally works with melatonin to put you to sleep. Now because your sleep cycle is a very delicate process, the things you do can highly affect your sleep. The color of your room can affect how fast you go to sleep and if that sleep made you tired in the morning.

flow changes, and even a condition called cardiomyopathy. The pancreas can also be effected by

Subpoint- According to Dr. Joseph Marcela, “It also lowers blood pressure, clears blocked arteries, and improves our immune system” (Borreli, Lizette).

Also, large substances such as, proteins are broken down by enzymes called proteases into amino acids, which is used and stored as energy. An example of this is; when the body gets exhausted the fuel which is converted from the protein is used as energy and also to repair worn out tissues to keep the body healthy and energised. It also stimulates the immune system and aids the body in ATP production.

In addition to elevated blood pressure, retention of fluid leading to edema and leakage of

The cardiac muscle cells can be affected by heart disease through the inability to maintain its homeostasis through the calcium pump. If there is excess calcium within the heart it results in the in ability of the heart muscle to relax. As a result, the ADP/ATP ratio increases, phosphocreatine decreases, and energy stores are depleted. Furthermore, this imbalance affects the energy needed to relax the left ventricle. Secondly, diastolic heart failure can occur from changes in preload, afterload, renin-angiotension-aldosterone system, and the sympathetic nervous system. These changes affect the fibrillar collagen within the extracellular matrix that affects the ability of the ventricular to relax. These changes along with those compensatory mechanisms results in continuous resistance that results in increased in left ventricular end-diastolic pressure (McCance & Huether, 2010).

This narrowing leads to poor perfusion of the body and the serious complications affecting the blood vessels of the heart (coronary heart disease), the extremities (peripheral vascular disease), the eyes (retinopathy), the nerves (neuropathy), and the kidneys (nephropathy). Poor circulation and perfusion results in

It is only recent studies that have shed light on its role in optimizing energy metabolism, bolstering cellular protection, reducing oxidative damage, and decreasing inflammation. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/)

from the actin. He also states when energy is released from the conversion of ATP to

This triggers relaxation of arterial and trabecular smooth muscle, leading to arterial dilatation, venous constriction, and erection.

Arteriolar vascular constriction, heart rate increases, and renal retention of sodium and water all help to regulate cardial output. Ventricular dilatation is commonly seen. A large amount of ventricular myocardium is lost, contractility may be greatly compromised, and cardiogenic shock may ensue.

Adenosine is another neurotransmitter; adenosine strongly inhibits serotonin release. Chronic caffeine use increases the number of adenosine receptors.(The body is trying to compensate for the constant presence of caffeine, which occupies and blockades adenosine receptors and thus interferes with adenosine reception.) When caffeine is withdrawn, however, the chronic caffeine user is left with too many adenosine receptors. Having too many adenosine receptors is equivalent to having too much adenosine. As a result, serotonin release is inhibited and this leads to migraine symptoms.