Adults Who Suffer From Chronic Migraine

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• Population- Adults who suffer from chronic migraine.
• Intervention- Onabotulinum toxin A [botox].
• Comparison- Botox injections versus topiramate as prophylactic therapy for chronic migraine.
• Outcome- Efficacy of botox as a prophylactic therapy for chronic migraine patients.

A limited literature search was conducted on July 15, 2015 using PubMed, TripDatabase as well as a focused Internet search. The retrieval was limited to human populations and documents published within the past 5 years. A total of 99 journal articles were found and reviewed. The abstracts were scanned for relevance and 20 were identified as containing important information. These 20 articles elucidated 18 new articles which were included as well.

Chronic migraine is a debilitating condition with over $1 billion in medical cost and $16 billion in lost productivity per year in the United States. (25) Here we examine the efficacy of onabotulinumtoxinA [botox] injections versus topiramate as prophylactic therapy for chronic migraine (CM) in adults. Chronic migraine (CM) is a specific and relatively newly defined sub-type of Chronic Daily Headache (CDH) defined as “more than fifteen headache days per month over a three month period of which more than eight are migrainous, in the absence of medication over use. Episodic migraine is the other migraine sub-type, which is defined as less than 15 headache days per month.” (14)
Due to the severity and duration, people with chronic migraine may
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