Katrina Samborski
Honors English 1100
Dr. Nicole Caswell
November 10, 2012
Advancement of Medical Research from HeLa Cells HeLa simply stands for Henrietta Lacks, a young mother in the 1951 who went to the doctor complaining of vaginal bleeding and discovered she had cervical cancer. Henrietta’s cells were taken for a biopsy and were found to be like nothing ever seen before; her cells were immortal. Her cancer cells double every 20 to 24 hours and have lived on for the past 60 years. Since HeLa cells were created, our world of modern medicine has been completely changed. We now vaccines for once incurable diseases and have used the cells for cloning and other biomedical research. Although the cells have done a great deal of good,
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HeLa cells have had a positive influence on medicine in many ways including with giving us knowledge about the human papillomavirus (HPV) DNA and HPV18-positive. HeLa cells have been linked to changes in microRNA expression. Since HPV18 has been associated with very aggressive adenocarcinomas, this finding may explain why Dr. Gey was surprised by the prolific growth of HeLa cells in culture. Routine Papanicolaou smear screening may not detect rapidly progressive cervical carcinomas; the new HPV vaccine holds the promise of preventing these tumors. (Hutchins). The problem of possible contamination of other long-term cultured tumor cell lines with HeLa cells not only caused an international embarrassment, but also raised the concern of misattributing a specific property so another cell line, for example, a virus or a tumor-specific marker, which actually belongs to HeLa. With the continued and growing use of tissue culture in biochemist research, intra- and interspecific contamination becomes a significant risk. The determination of stable genetic markers on cultured cells is a powerful tool for monitoring such contamination. Recent experiments in which cultured cells and innumerable clones of somatic cell hybrids have been used for genetic analysis have shown that, with the proper use of polymorphic markers to characterize the cells, the possibility of undetected cross contamination of cultures is no longer the problem it once may have
Her cells, taken from a cervical cancer biopsy became the first cells to reproduce infinitely in a lab. HeLa cells are still the standard in labs around the world today. Before HeLa cells, scientists spent more time trying to keep cells alive than actually performing research on the cells. There is an endless supply of HeLa cells and this allows more time for new
In 1951, the first immortal cell line was created by a doctor at Johns Hopkins Hospital using tissue samples taken from a young, black woman named Henrietta Lacks. Her cells would come to be known as HeLa cells, and for a very long time, the owner of these cells was a mystery; even her family did not know about them. For years to come, her cells would be used in many important medical and scientific advancements. Over that time, HeLa cells would prove to be instrumental in developing a polio vaccine, gene mapping, and in vitro fertilization. They would even be sent to space to see how cells would react in zero gravity.
The Immortal Life of Henrietta Lacks, by Rebecca Skloot, is the story of Rebecca’s journey in discovering the truth behind HeLa cells. HeLa cells are the first line of”immortal cells” grown in culture; scientists have tried to culture cells before, but the cells died within days of incubation, so HeLa cells were a revolution in the scientific world. With HeLa cells, scientists created vaccines for polio, tested nuclear radiation, and saw how cells reacted in space. Companies benefited when they produced HeLa cultures, and made millions. Although, not many people knew where HeLa cells came from or Henrietta Lacks, whose cells were cultivated without her consent and named HeLa, died of cancer without her
Due to the fact that Henrietta’s cells were the first human cells grown in a lab that did not die after a few cell divisions, they could be used for conducting many experiments. Her cells were considered “immortal”. This was a major breakthrough in medical and biological research. One major breakthrough was the development of a vaccine for polio. To test the vaccine the cells were quickly put into mass production in the first-ever cell production factory. Another enormous breakthrough was the successful cloning of human cells in 1955. Demand for the HeLa cells grew quickly. Since they were put into mass production, Henrietta’s cells have been mailed to scientists around the globe from “research into cancer, AIDS, the effects of radiation and toxic substances, gene mapping, and countless other scientific pursuits.” (Smith, 2002, "Wonder Woman: The Life, Death, and Life After Death of Henrietta Lacks, Unwitting Heroine of Modern Medical Science".) HeLa cells have been used to test human sensitivity to tape, glue, cosmetics, and many other products. Scientists have grown some 20 tons of her cells, and there are almost 11,000 patents involving HeLa cells. (Batts, 2010)
The HeLa cells (the name for Henrietta Lacks cells) led to the discovery of polio vaccines, genetic medication, HPV vaccine, and much more. Still today, these HeLa cells are being researched and used to protect the public from life-threatening diseases such as cancer and tuberculosis. The public health response to new medical advancements and research from the HeLa cells has had many positive and negative consequences on the individuals, families/communities, and the nation.
The HeLa cells are the first immortal cell lines. Immortal cell lines are not like other cells. These cells don’t die of old age. Immortal cells are important because these cells grow indefinitely and they survive and grow by dividing. This allows scientists to research more productively. HeLa cells are used for many researches to cure diseases and develop new drugs. With HeLa cells scientists did many researches and it led to breakthroughs in the study of leukemia, influenza, hemophilia, Parkinson’s disease, cancer, AIDS, and more. It became one of the important tools in medicine. These improvements in diseases saved lives of many people. HeLa cells are coming from an African American female from Baltimore. HeLa cells are taken from Henrietta Lacks’ cervix
Learning how certain medicines affected a cell during different time intervals. HeLa became the base for all cell experimentation. This allowed scientists to standardize culture techniques and materials. HeLa truly began modern research of the cell.
In 1951, Henrietta Lacks was diagnosed with cervical cancer at John Hopkins Hospital. Without any consent, Henrietta’s doctors took tissue samples from her cervix and attempted to grow them and keep them alive. These cells, known as HeLa cells, began to grow at an unbelievable rate; The HeLa cell became vital for the development of vaccines and other scientific research. However because of Henrietta’s race and economic standpoint, Henrietta Lacks and the rest of the Lacks family was exploited by doctors. The exploitation of the family allowed the doctors and researchers to benefit scientifically and monetarily.
HeLa cells are the most widely used human cell lines in existence. They are used in many experiments. For example, recent studies have shown that expression of girdin is associated with types of cancer. The expression of gidin was suppressed when in HeLa cells in vitro which allowed the gidin to be evaluated. It was found that patients with high-grade cervical cancer tumors exhibited strong expression of girdin. It appeared that girdin is key in HeLa cell
Her cells, taken without her consent from a cervical cancer biopsy, became the first human immortal cell line. Rebecca Skloot’s book, The Immortal Life of Henrietta Lacks, tells about her life, her cells and her family. It discusses both the stories of the Lacks family and the history behind the HeLa cell line. HeLa has been the cornerstone of numerous medical advances. For nearly 60 years, the body of the woman who revolutionized modern medicine laid in an unmarked grave in Clover,
The doctors were uncooperative with the Lacks family, the did not fully particularize the procedure that she underwent or the effect it would have on her. Furthermore, the healthcare professionals went drastically further in violations of her rights by taking a sample of her cancer without her permission numerous on numerous accounts. This is unacceptable practices conducted by the doctors. On the other hand, these cells became the groundwork for scientists to excel, luxuriating in breakthroughs achieved. The “Hela cells” contributed a variety of science fields from a vaccine for the polio virus, cloning, and gene mapping all comes through the use of her cells. Decades after her death the cells are still being used, her accomplishments in the field were relatively unknown till a student wrote this book. Henrietta Lacks never received the recognition for her helps in the achievement of the advancement of science, however, for a feat of this size one should receive glorification. For a student to have gone out of her way for someone they barely know, above all is unbelievably heart warming. This book shows us the unethical way that doctors practiced, but it turned out to better humanity, then left to examine this struggle to generate their own presupposition. The cells taken from her, furthermore, her family never received financial support. Consequently, this should not bother anyone at
Two very important viruses that HeLa cells were used to study were HPV, and HIV, scientist learned that "HPV inserts its DNA into the DNA of the host cell, where it produces proteins that cause cancer (Skloot, Pg. 213)" . Scientist could even further modify HeLa cells to act like specific cells by inserting the DNA of one cell into the other cell, in this case scientist took the DNA of red blood cells and inserted it into the HeLa cells, making them susceptible to be infected by HIV (Skloot, Pg. 214). Researchers could then research medical viruses by altering HeLa cells making them even more useful. Additionally, HeLa cells weren't the only immortal cells still being used, a new line called MO was developed, which originated from John Moore who had hairy cell leukemia a very rare form of blood cancer, and with different types of cancer cells came with new "rare proteins that pharmaceutical companies could use to treat infection and cancer" (Skloot,
Imagine your tissues growing around the world daily, and they never stop. This happened to Henrietta Lacks. She is best known for the cells that formed the HeLa cell line. This cell line has been used extensively in medical research ever since its successful culturing in 1951. HeLa cells have sparked a large debate on ownership of tissues and cells. Discussions have occured about these issues ever since HeLa cells were discovered. Still today millions of tissue samples have been used without the owner’s knowledge. If a person’s identity has been removed from the tissue, scientists do not have to ask permission to use them for their benefit. This has sparked problems because people’s opinion on this vary depending on what they know about DNA
HeLa cells are cells collected from Henrietta Lacks that have helped in many different medical advancements. HeLa cells helped to create in vitro fertilization, the polio vaccine, and some cancer treatments, to name a few. They were cervical cancer cells that served as an immortal cell line for scientific research. HeLa cells were the first line of human cells that survived in a test tube. They were taken and grown by Dr. George Gey in 1951.
After Gey succeeded to find the immortal human cells, he started to sell HeLa cells without Henrietta’s consent. “Gey sells HeLa cells to researchers in Texas, India, New York, and many others place” (Skloot 84). He did not give any credit to Henrietta. He only told Henrietta that her cells will help many people in the future. “In fact, in the future HeLa cells were contribute into polio vaccine; develop drugs for treating herpes, leukemia, influenza, hemophilia, and Parkinson’s disease” (Skloot 22). Hela cells were also used in cancer treatment and were the first cells that were shot into space.