Advantages And Disadvantages Of Benzofuran

In the next step, 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-fluorophenyl)acetamide (3a) was subjected to condensation reaction to afford N-(substituted)-2-((6-oxo-5,6-dihydroimidazo[2,1-b][1,3,4]thiadiazol-2-yl)thio)acetamide (4a-m) and their structures were confirmed by spectral analysis. The FT-IR spectrum of compound (4a) showed characteristic absorption bands at 3255cm-1 (NH), 3024cm-1 (ArC-H), 1614 (C=O), 1263cm-1 (C-S) and 1588cm-1, which could be attributed to (C=N). The 400MHz 1H-NMR spectrum of compound (4c), showed a singlet for the amide NH proton at δ 10.37ppm. The signal corresponding to the two protons of NH2 group in the 2-aminothiadiazole ring disappeared and a new sharp singlet for imidazole protons was appeared

The compound aquapentaamminecobalt(III) Nitrate, [Co(NH3)5OH2] NO3, is a metal complex bonded to the molecule nitrate to attain a neutral charge. The synthesis of this molecule is a more complex one, requiring the recrystallization of an intermediate species. When the complex has been formed and isolated via filtration, the complex can be reacted with various aqueous solutions, one being dimethyl sulfoxide, C2H6OS. When reacted these reagents form the compound Co(NH3)5(OS(CH3)2)3+, H2O, and NO3-, though not inn this ratio. Specifically the aquapentaamminecobalt(III) molecule can be used to study the sixth coordination site on the molecule where the later is bound. Because of the weaker bond between the cobalt ion and the water

Chemically active extraction is a highly useful method of separating organic compounds in mixtures (Padias 128-37). Organic acids and bases are soluble in organic solvents, but their corresponding salts are soluble in water. Therefore, if one had a mixture of an acidic organic compound and a basic organic compound in an organic solvent, addition of a base

Aim: To classify unknown substances according to their structure type and to observe how the structure of materials affects their uses.

A Cobalt-Amine-Halide compound is synthesized from cobalt (II) chloride hexahydrate. An orange-tinted solid is produced and is considered to be unknown since the specific ligand amounts are unknown. By determining the percent composition of various elements and compounds in the unknown, its true identity can be predicted. Chloride, ammonia, and cobalt are three examples of percent compositions determined to help narrow the selection of possible unknowns. Titrations using Na2S2O3 and HCl to determine percent cobalt and ammonia, respectively, are used. Silver nitrate is used to precipitate the chloride ions in the unknown, which can be measured to determine the percent composition of chloride

As it can be seen in the phenol the electric charge is delocalized on the benzene annulus only while the nitrophenol has its charge delocalized on the benzene and the nitro mathematical group ing . There other differences between p-nitrophenol and o-nitrophenol, with polarity being a commonly discussed issue . For both isomers, the nitro and inebriant group are more electronegative than the carbons on the ring and therefore the attachment in both are polar, however the adhesion in o-nitrophenol are less polar. O-nitrophenol already has intermolecular bonding within its structure between the proton of the alcohol group and one of the oxygen ’s from the N group occurring because the positions of both are close to each other

The second cause of death worldwide is Cancer [1]. It is expected that the number of people that will die because of cancer in 2030 is about 13.1 million [2]. It is better to develop novel, safe and effective chemotherapeutic drugs to treat cancer with minimal side effects. The pyridine ring is one of the most well known nitrogen containing heterocyclic compounds. Pyridine derivatives possess a wide spectrum of biological properties such as antifungal [3], antimicrobial [4-10], antioxidant [11], and anticancer [12-14]. α-Aminophosphates is one of the biologically active compounds may be because they are analogues to α-amino acids [15, 16]. α-Aminophosphonates and their derivatives are considered to be bioactive molecules due to their biological

Sriram et al. (2011) synthesized 2-(substituted aryl)-N-(substituted) thiazolidine-4-carboxamides. These compounds were synthesized from 2-(substituted aryl)- N-(substituted) thiazolidine-4-carboxamides . 2- (Substituted aryl)-N-(substituted) thiazolidine-4-carboxylic acids synthesized when Potassium acetate was added to a solution of L-cysteine HCl in water. Appropriate aldehyde was added to this mixture. To this mixture, desired primary or secondary amine was added to get required

This drug is normally supplied as white crystalline or in a solid powder. It’s usually soluble in organic solvents for example DCM, DMF, ethanol, DMSO and methanol which can be executed with any noble or inert gas. Its s

These tools give useful insight of information regarding the nature of target-ligand interactions, which consequently predict molecular models which are further used for the lead discovery and optimization. Ligand-based designing approaches are based on the information about structure of the active ligand which can interact with biological targets. The efforts for the designing of the novel drug molecule is based on the concept known as molecular similarity; compounds with high molecular structural resemblance with pre-existing ligands, are more likely to have similar pharmacological activity profiles. This approach is considered an indirect methodology as it is usually followed in absence of the 3-D structure of the target or if the target is unknown or cannot be predicted.

By use of partitioning between an organic and an aqueous phase, an analyte can be separated from an interfering matrix. Liquid-liquid extraction involves two steps; complex formation with the dissolved extractant in the aqueous phase and the transfer o f the complex from the aqueous into the organic phase. LLE has some advantages such as simplicity and ease of operation. However, this approach presents several drawbacks and limitations like consumption of large amounts of hazardous organic solvents and sample volumes, limited enrichment factors, time consumption and the formation of stable emulsion at the interface of the two phases. In addition, the generation of large amounts of pollutants makes this procedure tedious, expensive and environmentally unfriendly. Therefore, alternative unconventional LLE methodologies such as: dispersive liquid–liquid microextraction (DLLME), dispersive liquid–liquid microextraction based on solidification of a floating organic drop (DLLME-SFO), homogeneous liquid–liquid extraction (HLLE) single drop microextraction (SDME) and cloud point extraction (CPE) have been introduced and developed to address the limitations in the LLE .( Recent development and applications of dispersive liquid–liquid microextraction, Recent developments in homogeneous and dispersive liquid–liquid extraction for inorganic elements determination. A

Silver salts have been used as a separation facilitator since 1944. In this early work, an aqueous solution of the silver salt AgNO3 at 50 wt% was used in the absorption and extraction of light olefins from

The result for QSAR and docking studies will provide structural characteristics of the active ligands and also give detailed information about binding features which can useful

The research topic that I chose to write about is benzene and how it is used in oil refinery. Benzene is a flammable, colorless liquid that has a sweet odor to it when it is exposed to the air, although it evaporates very quickly (ACS). It is formed by human activities and through natural processes (ACS). Benzene is one of the twenty most used chemicals in the United States because it is commonly used as a starting material to make other chemicals like dyes, rubbers and plastics (ACS). Benzene use to be used as an industrial solvent but this isn’t really common anymore (AC). One can find benzene in cigarette smoke, gasoline, car exhaust, and crude oil because it is a natural part of them all (AC). People usually become exposed to benzene by breathing it in, but it can also be absorbed through your skin resulting in cancer (ACS). Since benzene is a hazardous chemical, OSHA (occupational safety and health administration) has regulated it to 1ppm (part per million) for an average work day and 5ppm (parts per million) in fifteen minute intervals. Also, while working with benzene you are required to wear a respirator (ACS). Benzene was produced by petroleum and petrochemical industries by recovery from reformat and liquid by products of the ethylene manufacturing process (ACS). Currently, benzene is commercially recovered from petroleum sources and coal (ACS). More than ninety-eight percent of benzene produced in the United States is derived from the petroleum refining and

It can be concluded that mixed primary and secondary iron nanoparticles were synthesized in Mt and PVP involved borohydride reduction system. In addition, the nanoparticles contained an iron oxide-coated α-Fe core and a PVP surface layer. Also, the clay-polymer interactions made PVP not only adsorb on the external surface but also intercalate into the interlayer space of Mt particles, developing a polymer barrier on the clay mineral surfaces. Due to the barrier-related steric hindrances and/or alkaline pH-derived electrostatic repulsions, the clay mineral particles built a card-house flocculation structure, which after suitable washing and drying can convert to a semi-card-house form in dry products. [2]