Advantages And Disadvantages Of Bio-Printing

AS well as sustaining the ability to produce prosthetic limbs, 3d printing is also extremely useful for creating artificial organs for needy patients in hospitals. But not only organs, but skin, bone, cartilage, blood vessels, surgical tools as well as even hearts and stem cells can just as well be made by these magnificent machines.

Organ donation provided a new therapeutic path when new drugs and devices failed to reduce the mortality and morbidity rate of patients with such illnesses as cardiovascular diseases. By replacing damaged organs or tissue with a functioning substitute, organ transplantation offers an immediate cure. Unfortunately, this “cure” is never guaranteed because of the high risk of graft rejection and that’s if a suitable donor can be found. Thus, tissue engineering has been the projected new treatment for these problems. Tissue engineering replaces the diseased or damaged tissue or organs with biofabricated counterparts made using the specifications dictated by the features of the specific tissue or organ.

The field of bioprinting, using 3D printing technology for producing live cells with extreme accuracy, could be the answer to many of the problems we as humans face in the medical field. It could be the end to organ waiting lists and an alternative for organ transplants. In 3D printing technology lies the potential to replace the testing of new drugs on animals. However, the idea of applying 3 dimensional printing to the health industry is still quite new and yet to have a major impact. Manufacturing working 3D organs remains an enormous challenge, but in theory could solve major issues present today.

In a study conducted through the U.S. Department of Health and Human Services on “average 79 people will receive an organ each day; however, an average of 22 people die each day” waiting for transplants that cannot take place because of the shortage of donated organs (U.S. D.H.H.S). The average amount of patients waiting for an organ can reduce to zero with the continued development of 3-D printers. 3-D printing is a process of making three dimensional solid objects from a digital file. The digital file is uploaded onto a computer software, and then the 3-D printer prints the digital file out onto different materials. The materials include plastic, resin, nylon, sandstone. The finish products become replicas of the digital file, and what was an idea is now a reality. Therefore, 3-D printers will one day be the future of organ transplants because over the past twenty years the technology industry has rapidly grown into the focal point in society. From advancement in communication, to the medical field, science and technology has shaped this world today. Thus, the American Government should invest more money into the medical field budget because the research conducted on new technology (3-D Printers) leads to more lives saved, and expands the opportunity of future medical breakthroughs.

Doctors and engineers have been working on another way to get organs a faster and more efficient way. Using 3D printers can help with their problem. They have worked on using a 3D printer to make organs that are a perfect match for patients. This can be very useful it can get an organ ready in a short amount of time helping the patient recovery faster as well. Organ transplants are hard to come by. One you have to be put in a waiting list, and people are usually on that list for a long while, just waiting for a perfect match to come. But sometimes it takes to long and some people die while still on the waiting list. But when an organ finally does come they feel bad because someone had to die in order for them to use it. So Dr Ali Khademhosseini is trying to use 3D printing to help solve this problem. His theory is he can make organs from a 3D printer, which can make the waiting list decrease faster and have people not have to die in order for a perfect match. 3D printers have been used to make Human cells, tissue, and blood vessels. But making something like a heart is much more difficult. Because you have to make the beating and pumps. (Mesley). There have been problems in the past that have just know started to show in some people. "Viruses aren't the only worry, and here too the past may serve as a guide. In 1956 injections of human growth hormone became a standard therapy for children failing to develop properly. The hormone was extracted from

In the past, the only way to replace diminished cells, tissues, and organs was from organ transplantation. An organ donor was needed, and the tissues would be surgically removed from the donated body and placed into the recipient. Due to the current research being conducted, it is believed that tissue engineering and organ printing can contribute to the process of improving and saving lives.

My exploration of this topic led me to an article on HuffingtonPost.com. The article is “How 3D Printing Could End The Deadly Shortage of Donor Organs” by Macrina Cooper-White. In said article,

3D printing is definitely a huge advancement in Technology! However, very controversial. Although, it has multiple benefits in our society in Medical health practices & Engineering speed, it can also be used for illegal purposes. Now, does the bad outweigh the good? That is the question debated today. I see the whole concept in only 2 large points. It will greatly help people who are desperately in need for transplant organs. It will drastically reduce the organ waiting list and once perfected, our life span should be bumped up a decade or so. On the other hand, what if someone down the road you'll be able to completely recreate a human being in it's entirety? Would we harvest them for their organs? Would it be fair? What if it falls in the

In the future, the technology will be widely accepted since it can be used to create complete organ, to test newly developed drugs on manufactured cells instead of animals and human cell, to imprint cells directly onto a human body, thus reducing the wait time for organ transplantation, and save time and cost associated with drug research. An absolutely favorable position of customized organs is designing organs utilizing a patient 's own particular cells. With this methodology, there would be no issues with dismissal, and patients wouldn 't need to take the powerful anti-rejection medications that are presently required (Cooper-White, 2015). According to the Organovo company, the formation of a suitable liver is a crunch second for the bio-printing and drug industry since it demonstrates 3D printed tissue can be preserved successfully for a sufficient time to test the impacts of medications on it or insert it in a human body where it can further mature (Mearian,2013).

Although there may be questions speculating the negative side of this technological advancement, the world should realize the benefit. 3D printers can cure many unknown diseases and aid many disabled individuals. As said by Bernard in the novel Brave New World by Aldous Huxley, "We preserve them from diseases. We keep their internal secretions artificially balanced at a youthful equilibrium” (pg 111). The World State in the novel may consist of immortality and beauty, however, in modern times humans can’t be compared to this world. Our society can improve the people’s health, aiding them in medical advancements that are unimaginable. Therefore, many civilians have turned to medical facilities clinics to provide the necessary organs in order to survive. 3-D printing is greatly important for civilization because people are suffering from disabilities and custom made body parts could save many lives. With no further to do, even though this technology has some negative aspects, the positive attributes should be much more viewed with interest for it can save many lives in the next few years to

Bioprinting offers the ability to create a 3D biomimetic tissue by patterning cells and, in some approaches, multiple cell types with precise and reproducible spatial control. In order to create these organs a researcher must start off with a bioink consisting of compounds with a chemical structure consisting of polysaccharides and/or proteins. Some of the compounds include, but are not limited to agar, collagen, silk, elastin, and chitosan. These bioinks are then infused with additives that include growth factors, cytokines, and extracellular matrix (Bioprinting 4-12). Bioprinting then “moves from the laboratory to the clinic sources, clinical grade cells will be necessary to support the assembly of different constructs” This is where stem cells from the patient, if possible, are utilized to prevent the use of immunosuppressive drugs. (Bioprinting 4-12). Once everything is loaded into the biopen, it is then loaded into the bioprinter (fig 1, 2). Researchers are then able to make tissues, organs, and many other structural components.

This is nothing new. In the past decade, clinicians, surgeons, and scientists have been collaborating with other disciplines to create parts of organs or artificial skulls from 3-dimensional bioprinters. Many promising signs of progress have been made, such as the success of reconstructing the skull of patients who suffer head trauma or neurological disease, or a functional trachea that response to

As a result, a researcher from Wake Forest University named Professor Anthony Atala did a TED talk in 2011 on a demonstration on how to print a living human kidney, in which after the demonstration caused confusion in the crowd due to the research being in the early research stage and has never been previously used for a viable organ transplant (Lipson and Kurman 7). The TED talk demonstration was the world’s first introduction to the use of bio-printing viable organs for possible transplantation. In consideration of the TED talk, researchers have begun to harvest stem cells to 3-D print, in hopes to integrate with the existing tissue to produce viable organs and other body parts (Griggs 8). The bio-printing process has begun to have some success with clinical trials. In 2013, a surgeon named Doctor Paolo Macchiarini had a patient that is a 2-year old girl named Hannah from Illinois, who was born without a trachea (Griggs 9). Dr. Macchiarini created a bio-printed trachea from Hannah’s own stem cells and bone marrow, after in which he performed the 9-hour operation (Griggs 9). As a result, Dr. Macchiarini allowed Hannah to breath on her own and he will monitor her throughout her life, but for right now she is responding well to the transplant (Sifferlin 2). In result, bio-printing may begin to save and improve a lot of individuals’ life. Since, each day 18 people die in the

There are over 11.4 million amputees worldwide in need of prosthetic limbs. Traditional methods of producing prosthetics limit availability due to cost and durability. While the technology is still very new and not well developed, 3D-printing is the future of prosthetic limbs. 3D-printed prosthetic limbs may be printed with different materials, and provide quick production with a lower cost, which can increase the availability of prosthetic limbs to more amputees.

With the very limited supply of organs, 3D printing creates functioning organs without a donation from a living organism. The definition of 3D printing from Charles W. Hull, the inventor of 3D systems, states that “...thin layers of a material that can be cured with ultraviolet light were sequentially printed in layers to form a solid 3D structure” (Murphy & Atala 773). The sheer narrow sheets play a vital role in bioprinting. They allow the printers to develop functional, layering individual cells, proteins, and an extracellular matrix. The three basic types of 3D printing include biomimicry, independent self- assembly, and miniature tissue blocks. The creation of the 3D structure creates all the difference between these types of printing. Three dimensional structure approaches include, creating exact duplicates of the cells and tissues with extensive knowledge, using a developing embryo as a template or using microscopic tissues to assemble into a larger developed tissue (Kalaskar). In other words, all these paths to bioprinting end up with a 3D structure but require different knowledge and materials. They all contain their own sets of challenges.