Advantages And Disadvantages Of Lactoferrin

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A direct relationship between breast feeding and health of an infant had been recorded periodically for thousands of years across many civilizations (1). In 1934, a report on 20,000 mother infant dyads in the U S, found that morbidity or mortality due to intestinal infections, was higher for non breast fed infants than for breast fed infants (2). However, with improved nutritional content of artificial infant formulas and better hygiene in the 1950s and later, greater weight gain, simultaneous and dramatic reduction in infant mortality rate, many thought that this relationship was no longer relevant. After this many Pediatrician and child care nurses, actively discouraged breast feeding. However, subsequent epidemiologic studies (3, 4, 5)…show more content…
Unbound iron is an essential nutrient for many bacteria, and by making it unavailable, lactoferrin would also have a broad bacterio static effect. Lactoferrin also inhibits path biology of several bacteria (34, 35), stimulates phago cytosis of pathogens by macrophages (36), and inhibits human immunodeficiency virus, cytomegalovirus, and herpes virus (37, 38). Partial digestion of lactoferrin produces lactoferricin B, a positively charged peptide loop of 18 amino acids with potent broad antibacterial activity for both Gram positive and Gram negative bacterial…show more content…
Bottcher, M. F., Jenmalm, M. C., Garofalo, R. P. & Bjorksten, B. (2000) Cytokines in breast milk from allergic and nonallergic mothers. Pediatr. Res. 47: 157–162. 27. Bottcher, M. F., Jenmalm, M. C., Bjorksten, B. & Garofalo, R. P. (2000) Chemoattractant factors in breast milk from allergic and nonallergic mothers. Pediatr. Res. 47: 592–597. 28. Michie, C. A., Tantscher, E., Schall, T. & Rot, A. (1998) Physiological secretion of chemokines in human breast milk. Eur. Cytokine Netw. 9: 123–129. 29. Garofalo, R., Chheda, S., Mei, F., Palkowetz, K. H., Rudloff, H. E., Schmalstieg, F. C., Rassin, D. K. & Goldman, A. S. (1995) Interleukin-10 in human milk. Pediatr. Res. 37: 444–449. 30. Bryan, D. L., Hawkes, J. S. & Gibson, R. A. (1999) Interleukin-12 in human milk. Pediatr. Res. 45: 858–859. 31. Hawkes,J.S., Bryan, D. L., Neumann, M.A., Makrides, M. &Gibson,R.A. (2001) Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. Lipids 36: 1179–1181. 32. Calhoun, D. A., Lunoe, M., Du, Y., Staba, S. L. & Christensen, R. D. (1999) Concentrations of granulocyte colony-stimulating factor in human milk after in vitro simulations of digestion. Pediatr. Res. 46:

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