INTRODUCTION:
Silver is bright and shining metal known to mankind from ancient times. From ancient time’s human civilization are using silver for jewelleries, utensils, weapons, coin, medicine, water containing tanks. From early days silver is assisting the immune system when it was plentiful available in dissolved metallic form in water[1]. In periodic table it is placed at 47th position near to heavy metal.it is a transition metal. It has atomic weight 107.8. Silver has good metallic property like malleability, ductility, thermal conductivity and electrical conductivity [2]. Silver exhibit the excellent anti-microbial property. After the development of nanotechnology we are using silver extensively in various area. Now a day we use silver nanoparticles (AgNPs) instead of metallic silver for many of daily uses. It is seen that AgNPs is highest degree of commercialisation among all the Nanoparticles in medical and health sector. There are numerous uses where AgNPs are used like in cloths, medicines, disinfectants, tiles, surgical equipment, and silver coated bone prosthesis. Nao silver is also used in room spray, paints and laundry detergents. Many manufacture using nano silver in washing machines and refrigerators. Silver coated or vessels are used to preserve water and wine mainly during long voyages.
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With the numerous advantages AgNPs have the potential risk of toxicity to human body. Several studies showed that AgNPs shows the toxicity toward various organs of human body like lungs, liver, kidneys, vascular system and skin. AgNPs induce cell cycle arrest due gene expression at different check points of cell division. AgNPs causes toxicity in manner as ROS generation, oxidative stress, DNA damage and finally apoptosis. These are all preliminary findings more comprehensive studies are needed to have clear image about the mechanism by which AgNPs causes cytotoxicity and
The AAP is a potential trigger of cytochrome P450 that induced the high reactive quinone-imine production. This matches with sulphahydryl groups in proteins and result in rapid depletion to intracellular glutathione(35). Generally, one parts of the potential intracellular antioxidant defensive system is glutathione that consumes the singlet oxygen, superoxide and hydroxyl radicals(36). Enhancing of intracellular flux of oxygen free radicals results from glutathione depletion leads to oxidative stress in hepatocytes(36). The increasing the serum levels of GOT, GPT and ALP have been attributed to the structural integrity hepatic damage(37). In liver tissue, GOT and GPT are located in cytosol and mitochondria. In following of liver damage, hepatocyte transport function disturbed
The present study investigates the cytogenetic changes that could be induced in cancer cells after treatment with PDT. In this work, we evaluated the cytotoxic and genotoxic effects that could be induced by 5-ALA/PDT on two different cancer cell lines; adenocarcinoma breast cancer (MCF-7) and hepatocellular carcinoma (HepG2). When MCF-7 and HepG2 cell lines treated with 5-ALA (0.5, 1, 1.5 and 2mM) alone for 4h then incubated for 24h, 5-ALA did not induce cytotoxic effects on both cell lines. Also, laser irradiation alone did not induce a cytotoxic effect on MCF-7 or HepG2 cells after exposure for 4min then incubation for 24h. These results are in agreement with the observations of Chu et al. [21], who found that both 5-ALA and its
Hydroxyl radical, product of the Fenton reaction, the most destructive species among oxygen radicals, is highly toxic and capable of attacking DNA, and oxidizing guanine bases resulting in the formation of mutagenic 8-hydroxy-2 '-deoxyguanosine (8-oxo-2dG) lesions. Among the purine and pyrimidine bases of DNA, guanine is the most sensitive base to oxidation. During an oxidative
In this lab we are going to create silver ornament using oxidation which is a reduction chemical reaction. The process used in this lab is similar to how silver mirrors are created. Mirrors have been around for many years, dating back to at least 3,000 years ago in China and the Middle East. The method for making these mirrors consisted of the hammering of bronze, copper, or tin sheets to make them smooth. The making of glass was developed in Rome in ancient times and 17th century Italy craftsmen had made a better method of lining the glass with the reflective metals that were listed before. Another process, created by a German chemist by the name of Justus von Liebig, involved the silvering of glass sheets with a thin layer of silver
Chinchar, V. G., Bryan, L., Wang, J., Long, S., & Chinchar, G. D. (2003). Induction of apoptosis
Silver (Ag) is a metallic element with the atomic number of 47. A soft, white, lustrous transition metal possesses the highest electrical conductivity, thermal conductivity and reflectivity of any metal. Silver occurs in its pure, free form as an alloy with gold and other metals, and in minerals such as argentite and chlorargyrite. More abundant than gold, silver metal has functioned in many pre modern monetary systems as coinable specie, sometimes even alongside gold.
Alteration in the antioxidant components like SOD and catalase, as noticed in this study has been linked to the cellular apoptotic signaling introduced by transcriptional factors and/or mitochondrial factors. The ratio of Bax/Bcl-2 in the high dose arsenic group (50mg/L) was significantly higher than that of the control group thus initiating apoptosis in liver and brain tissues [44]. Report reveals that inorganic arsenic-induced oxidative stress can cause cellular apoptosis in the cerebrum and cerebral locations [45]. These may be the reason behind the cerebrum and cerebellum tissue disarrangement and degeneration, in our present study. Green tea extract was found to be effiecient even in the restoration of the cellular morphology and tissue
Nanotechnology is the cross disciplinary in nature, drawing on medicine, chemistry, biology, physics, and material science (Nanotechnology for Electronics and Sensors Applications, 1). This is an entirely new substance with unique properties that become stronger, and conduct heat and electricity. Although this new technology is argued whether it is good or bad. Some say that when the nanoparticles are inhaled it can be harmful to lung tissue, or saying in the wrong hands can be used for terrorism. Even through these arguments the benefits of this new technology outweigh the bad substantially. Nanotechnology will change the future for the better.
“People with the highest sodium intakes had a 20 percent higher risk of death from any cause than people with the lowest sodium intakes.” It claims by Harvard T.H. Chan. Sodium is the sixth-most plentiful component on the Earth. Somebody usually refer to “sodium” and “salt” alternating, but it's not. Sodium is only a component of salt. Salt composed of 40%, 60% sodium, and chloride. Therefore, one teaspoon of salt about 5,000 mg gives approximately 2,300 mg of sodium. We use salt for preservative, so processed food have a lot of sodium. In addition, the sodium is in the MSG (monosodium glutamate), too. The average of North American takes sodium about 3,400 mg per a day. Experts suggest that we consume lower than 2,300 mg per a day and lower than 1,500 mg in the high-risk group. In Globalization, everybody often does the easiest way, even choosing the food, therefore many people choose to buy the frozen meals in regularly and people cannot avoid the diet that has high sodium, on the other hand, people can choose the diets in low sodium, in my
Nanoparticles are used because of their versatility in targeted drug delivery while minimizing toxicity. Gold is used as the basis for nanoparticles because it has a relatively high stability of ligand binding along with its decreased stability with other cells. Gold nanoparticles (AuNPs) also have a high concentration of glutathione, which is an antioxidant that prevents damage to cells from things like free radicals and peroxides.
In recent years Nano sized materials play the significant role in science and technology due to their unique shape, size, peculiar properties and potential applications. Metal nanoparticles, which possess considerable electronic, chemical and optical [1, 2] properties, are different from those of the bulk materials. Among the several metal nano particles gold (Au) nanoparticles have attracted rigorous consideration for their numerous applications in catalytic , sensing, imaging, diagnostics [3-6], tunable surface Plasmon resonance, surface enhanced Raman scattering, electrical, magnetic, thermal conductivity chemical and bio stability and anti-bacterial activity [7-13]. Besides, Gold nano particles have widely been used as the platform
Nanotechnology is a recently developed technique to produce nanoparticles. According to the definition from British Standards Institution, nanotechnology refers to the intentional design, characterization, production and applications of materials, structures, devices and systems by controlling their size and shape in the nanoscale range1. Nanotechnology covers versatile applications, such as medicine. Nanomedicine is defined as the field of medicine that aims to use the properties and physical characteristics of nanomaterials at the molecular level2. In general, nanomedicine exhibits tremendous advantages over conventional medicine. Therefore, it is widely applied for various purposes, for instances, diagnosis, prevention and treatment
The thin polymer films or powders are the most commonly form which these composites take them, as this is normally the simplest structure to prepare, and also good for exploiting the desired properties. In general, the techniques of preparation can be classified into two as ex-situ and in-situ methods[5]. In the ex-situ process, at first the metal nanoparticles are synthesized, and their
Yet another CNTFET device geometry entails suspending the nanotube more than a trench to reduce contact with the substrate and gate oxide. This technique has the benefit of reduced scattering at the CNT-substrate interface, enhancing device overall performance. There are numerous methods used to fabricate suspended CNTFETs, ranging from growing them over trenches using catalyst particles, transferring them onto a substrate and then under-etching the dielectric beneath, and transfer-printing onto a trenched substrate.
Zinc oxide is a semiconductor material II-VI studied since the middle of 20the century. Most of the physical properties of massive ZnO are therefore well known for several decades. The interest of the researchers then declined, partly because of a major technological lock for the use of ZnO in optoelectronics, namely the impossibility of doping the p-type ZnO.