Advantages And Disadvantages Of SLN

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NLC were idealized to overcome inherent disadvantages of SLN. Entrapping structure is a blend of solid and liquid, spatially incompatible, lipids that confers distinct characteristics of NLC when compared with other lipid NPs [80]. Indeed, since the matrix of the lipids composing the nanostructured lipid carriers is more amorphous than for SLN, association efficiency is higher and offers a slower release [81]. The nanodroplet of liquid lipid, containing most of the drug to entrap, becomes dispersed within the solid lipid, granting a slower migration of drug to the outer phase and, therefore, a higher entrapment that lasts longer.
It was suggested that using NLC to carry and delivery domperidone in the buccal cavity could lead to a permeability
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The ideal polymers for nanoparticle production must be biodegradable and biocompatible. Moreover, when NPs are produced as buccal delivery systems, the polymers must be mucoadhesive to increase residence time, enhancing the amount of drug that permeates the mucosa and reaches systemic circulation [86]. The mucoadhesion can be obtained either by the formation of electrostatic or hydrogen bonds. Since mucin presents a negative net charge, cationic polymers are preferable for production of mucoadhesive NPs. Moreover, due to hydrophilic nature of mucin, polymers that present a higher number of functional groups capable of establishing hydrogen bonds are preferable…show more content…
In order to develop and optimize polymeric NPs as buccal delivery systems, Pistone et al. chose chitosan, pectin and alginate as matrixpolymers and tripolyphosphate and zinc as negative and positive counterions, respectively [90]. The polymer:counterion proportion was thoroughly studied to achieve the most stable and suitable particles for buccal delivery. The stability was determined by assessing nanoparticle aggregation and disintegration in contact with simulated salivary fluid, along with the variation of polydispersity index, hydrodynamic diameter and zeta-potential. It was observed that alginate NPs presented good stability during 120 min in contact with artificial saliva since some parameters did not significantly vary throughout of the course of the assay. Even though the chelation of zinc ions would be expected due to the high content of phosphates in artificial saliva, so it was suggested that the presence of calcium in the dispersion media prevented the zinc chelation and maintained the structure of alginate NPs intact, as expected to occur in vivo [91]. The size of pectin NPs significantly decreased (with consequent variation of polydispersity index) after contact with artificial saliva, indicating either erosion and/or shrinking due to the formation of additional cross-linking with the ions present in the artificial saliva. The size
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