Advantages And Disadvantages Of Scaffolds

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As previously defined, a composite material consists of two or more materials where polymers are used as matrix materials usually. These materials behave together to produce the best properties of the scaffold, duplicating the same composite features of bone. In particular, polymer- based composite scaffolds may mimic the structure of natural bone which is mainly made of HA and collagen. Showing better osteoconductivity, HA can be considered the inorganic reinforcing phase of the composite scaffold, while polymers such as PCL, PLLA, PGA, PLGA function as the organic matrix. Bioactive phases creating reinforcement in the polymer-based composite can also change the degradation behavior. Composite scaffolds made of polymer reinforced with HA seem to be promising substrates for bone tissue engineering because of their outstanding mechanical properties and osteoconductivity.

While intensive efforts have
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The effective synergic role of -TCP bioactive particles and PLA fibers on the morphology and mechanical behavior of the final composite scaffold was assessed, as well as the interaction between the ceramic phase and the highly organized fiber-reinforced polymeric structure (60).

The integration of biodegradable PLA fibers into the PCL matrix allows a mechanical response that is ideal to maintain the spaces required for cellular in-growth and matrix production. The addition of bioactive -TCP particles, through a hardening reaction, generates needle-like crystals of calcium-deficient hydroxyapatite similar to natural bone apatite, which interact with the fiber-reinforced polymer. This interaction strongly enhances the mechanical response in compression by up to an order of magnitude
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