Advantages And Disadvantages Of Using C. Elegans

Scientist have seen that telomerase expressing clones have no difference in karyotype but have a long lifespan by 20 doublings. With this research, cells have been seen to have a very youthful looking state for much longer. A last area of study is the hypothalamus of the brain. This part of the brain controls reproduction, growth, metabolism, and aging. This is where many of the age related diseases occur. The study of this area can lead to many advancements in age related diseases that can help people live longer. Though this area of study does not have many advancements it holds promising results. Though there have been numerous advancements, many people ask the question whether people need to live longer because of an already over populated Earth.

All organisms in the world have a range of systems and organs in their body. Some organisms may share similar body systems while others have absolutely nothing in common. Several of those organisms include humans, pigs, crayfish, and earthworms. From their mushy, gushy organs to their soft, gentle skin, you may think, “How are humans and pigs possibly alike? Or a crayfish and an earthworm?” In many ways they may not be, but in other ways, they are very much alike. The body systems that will be compared and contrasted of these organisms are the nervous, circulatory, reproductive, muscular, integumentary, digestive, excretory, and skeletal systems.

The nematode Caenorhabditis elegans has ended up being a capable model for the investigation of maturing science. Strikingly, C. elegans tissues fall apart at various rates in maturing grown-ups, with specific highlights of age-related decrease strikingly reminiscent of those in higher life forms. Here they report two striking highlights of the maturing C. elegans sensory system—auxiliary regrowth and synaptic weakening. Morphological changes that happen amid maturing are neuron-particular and incorporate new dendrite outgrowth from forms or somata, with mitochondria regularly arranged at the branch point for the new neurite. Since morphological expanding or growing and synaptic decrease without cell passing exemplifies maturing human mind, enter factors in age-related neuronal decay might be preserved crosswise over phyla.

Humans undergo several stages during their lifetime including growth, development, reproduction and senescence. Senescence is defined as the deteriorative biological changes that organisms experience as they age eventually leading to death. These changes include low metabolism, a weak immune system, memory loss, poor vision and loss of hearing. Senescence begins in humans during their post-reproductive years. However, gerontology research has shown that individuals who reproduce late have longer life spans compared to individuals who reproduce early. Nonetheless, it does not indicate that senescence is inevitable. All organisms experience senescence,

National Institutes of Health in a study called the Hawaii Lifespan Study. The research focused on the human homologue of DAF-]6 which includes a protein group FOXO (Fork head box transcription factor) that functions as a sensor in the IIS pathway, as it has been shown to influence lifespan across a number of species. The researchers conducted a nested case control study on five candidate genes (ADIPOG, FOXO1A, FOXO3A, SIRT and COQ7), with FOXO3A found to have a significant impact in healthy human ageing and longevity. This research article is useful as it is a long term study based on finding the genetics responsible for determining longevity and healthy ageing. The author’s research is limited as it is only conducted on a homogeneous male population and more in depth data is needed by performing similar studies on other populations and

At the National Human Genome Research Institute (NHGRI) they conducted a study on age-related cell damage

It is a known fact that all measures of physiological function decline in human aging. While genetics certainly play a role in the declining of physiological function with age, it can be argued that a fundamental part of aging can be reflected by chemical processes resulting in the appearance of harmful side products of the normal metabolism over time. When enzymes speed up reactions it is harder to slow them down. At the same time side reactions are constantly occurring and more and more unwanted side products are continuously being formed.

Expression of mir124 and 184 decreased significantly in old R2 neurons. These results suggest that aging of neurons is associated with specific changes in expression of miRNAs. Furthermore, these results are consistent with our previous finding that aging is associated with neuron specific changes in gene expression [30].

Strikingly, C. eleganstissues fall apart at various rates in maturing grown-ups, with specific highlights of age-related decrease strikingly reminiscent of those in higher life forms. Here we report two striking highlights of the maturing C. elegans sensory system—auxiliary regrowth and synaptic weakening. Morphological changes that happen amid maturing are neuron-particular and incorporate new dendrite outgrowth from forms or somata, with mitochondria regularly arranged at the branch point for the new neurite. Since morphological expanding/growing and synaptic decrease without cell passing exemplifies maturing human mind, enter factors in age-related neuronal decay might be preserved crosswise over phyla.

Given the results of the experiment carried out it is concluded that the experimental gene ZK1225.1 is not involved with C. elegans functionality

Stem cell, being capable of giving rise to many other cells types, is one of the main developmental biology research methods in relation to flatworm regeneration. Major organisms, including flatworm taxa, are capable of showing little to no regeneration, leading to the observation of living species and how they interact to unravel the mechanism of regeneration, including aging. By utilizing the ability to observe BrdU labeling, used in cell proliferation, and maceration, the act of softening and breaking down skin due to moisture. Regeneration observed in living specimens showed to be a process that is completely successful when regeneration remained in the posterior-most pharynx level, otherwise failed if the animals lacked the brain & parts of the pharynx. Surprisingly, minimal cells are needed for a complete registration of the specimen, M. lignano that

In order to better understand aging-associated diseases, it is first necessary to define what aging is. Aging is a complex, multifactorial process of harmful mutations in cells and tissues that are accumulated over time and result in an increased risk of disease and, eventually, death (Tosato, Zamboni, Ferrini, & Cesari, 2007, p. 401). Contrary to the belief that aging can be cured through medical advances, it is scientifically accepted that, while human life expectancy has increased, the human life span has remained largely unchanged for the past 100,000 years (Tosato et al., p. 401). Therefore, future developments in aging research ought to focus on addressing treatment and prevention of major aging-associated diseases that will

This sequence lets scientists know the character and location of all C. elegans' genes. However, biochemists do not yet fully understand what each gene does and the goal of this experiment is to find the function of each gene within the worm. The connection between a worm's genotype and phenotype is important, because, believe it or not, human beings and worms share many of the same

For example, they are easy to grow on the lab since they reproduce fast, laying an average of 4 to 10 eggs per hour. They have a considerable short life span, which is about 2 to 3 weeks under suitable living conditions. In addition, they are transparent, which makes it easier to study the function of its organs, and observe the evolution from the egg stage to the adult stage. C. elegans have a surprisingly similar genome to those of humans, which makes them a great model to study human diseases. On the other hand, they also have some disadvantages because they are considerably small and in some way, it makes it difficult to manipulate them.

Aging is the process of becoming older, as we age, multiple mutations occur that concern all the processes of aging well as it compromising a number of different genes. There are many theories of biological aging, such as the Cellular Aging Theory, Immunological Theory, and the Wear and Tear Theory. The Cellular Aging theory describes the process of aging in which cells slow their number of replication, thus giving each species a “biological clock that determines its maximum life span” and how quickly one 's health will deteriorate(Hooyman, 42). After a certain number of years, each cell which follows an apparent biological clock starts to replicate itself less, thus the specific individual or species slowly deteriorates. This theory gives