Fast Disintegrating Tablets Essay

Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard” and “soft”. The hard capsule is also called “two piece” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard

The majority of medicines are formulated for oral administration. This means they are taken via the mouth, in the form of a tablet, capsule, liquid or suspension. These medicines come in a variety of

The antacid tablets were not crushed properly, resulting in big crumbs of the tablet which will affect the dissolving process of the lab.

Manufacturing theophylline formulations come with challenges for both the anhydrous and hydrate. For the anhydrous form, a study showed that the wet granulation of theophylline anhydrous in conjunction with microcrystalline cellulose, led to the formation of the monohydrate form of the drug. This is significant because the monohydrate has slower dissolution than the anhydrous form of theophylline. Thus the method of manufacture is highly important as the study showed directly compressed pellets had better dissolution profiles. Also it shows the importance of the choice of excipients as pellets manufactured via wet granulation in the absence of microcrystalline cellulose showed similar release to that of directly anhydrous theophylline.

The hypothesis was formed under the thought that the fastest dissolving pill would be the most effective because the sooner the ingredients and materials were realized, the sooner they would be able to attack and neutralize the pain, therefore getting the job done quicker or more efficiently. The hypothesis was not supported because, overall, the first two pills to dissolve were both children’s pain killers and were “junior strength”. Therefore, these medicines could not have been the most effective because the strength is significantly weakened to accommodate to young kids, and would not be as effective as normal strength medicines. In order to accurately determine the time taken for the pills to dissolve inside the body, it is very important to create a solution similar to stomach acid. Stomach acid was simulated by heating vinegar, which has the same ph level of stomach acid and shares other similarities in makeup and properties. The vinegar was heated to 36.7 degrees Celsius and constantly stirred to represent the temperature and motion of stomach acid. Eight different pills were timed to see how fast they dissolved. Each type of pill was tested three times in order to find an average for each medicine. The pills tested were Advil, Children’s Advil Grape Flavored, Ibuprofen, Children's Ibuprofen Grape Flavored, Tylenol, Tylenol Liquid Gels, Aleve, and Aleve Liquid Gels. The children's strength pills were the first two medicines to dissolve. Aleve was the slowest to dissolve and took almost two hours to dissolve. The liquid gel capsules were the second and third slowest pills to dissolve. In order, from fastest to slowest to dissolve, the medicines were Children's Ibuprofen Grape Flavored, Children’s Advil

In the experiment, I predict that the acetaminophen liquid soft gel capsules will take the longest to dissolve in the simulation gastric acid. The capsules will be the second most effective based on its reaction to the simulation gastric acid. Lastly the liquid form will completely dissolve, therefore being the least effective.

Wordell also explained that sustained release tablets have two important advantages over other drugs, one “they are effective for a longer period of time” and “two they frequently cause fewer adverse reactions.” Since sustained release tablets are designed to release the drug slowly over time, crushing or damaging the “wax matrix” may cause the patient to “receive too much of the drug too soon” and the patient “may suffer increased adverse reactions” as explained by Wordell. The expected effect of the drug may also not be met and the symptoms may reoccur before the next schedule dose Wordell further expressed. Sustained released capsule “contains beads” that releases the drugs in the same process as that of sustained release tablets. While you may be able to open a sustained release capsule and mixing the “beads” which food or juice, you must be very carefully and ensure that the beads or not popped during mixing Wordell emphasized. This will also cause the patient to receive too much of the drug at a much faster rate and this will also cause very serious adverse

The purpose of this investigation is to find out if the coating on pills makes it harder to dissolve.

Non-surgical treatment like SRP, oral hygiene instruction, chlorhexidine mouthwash was chosen for the patient. Even in the article non-surgical treatment was chosen as first option for most of the patients and it was required to reduce inflammatory component in the gingival tissue.

Patents should be taught to take this medication by mouth, that is may be crushed or mixed with liquids if necessary. The must be warned not to take this medication

SV (figure. 1) is antihyperlipidemic compounds which can reduce about 30% of LDL and total cholesterol in the body. In addition, SV was more tolerated by the body [1] than other antihyperlipidemic drugs, so that it became the drug of choice for most patients with hyperlipidemia [2]. Unfortunately, its solubility in water is very low, and it correlates with very low bioavailability [3]. One potential method to improve the simvastatin's solubility was made by co-crystal form. Co-crystal is a crystal whose a structured arrangement, consists of two main compounds (the active substance and the crystal-forming components) known as co-former with a certain stoichiometric ratio [4]. ASP and SAC are two examples of co-formers that used to increase solubility

Using a mortar and pestle, the weighted tablets are crushed manually and turned into homogeneous powder. Ground material is transferred to a 250 cm3 glass beaker with 200cm3 of deionized water in it. The solution is stirred with glass rod. This solution is transferred to a 250cm3 conical flask that had been previously washed with deionized water.

Drug dosage form (Liquids ,suspensions, elixirs are readily available for absorption because they are already in solution)

Valsartan is an Angiotensin II receptor antagonist selective for the type I (AT I) angiotensin receptor which mediates the release of aldosterone. A receptor antagonist, such as valsartan, has an affinity

Slow release: Enteric coated tablets are non crush, they are known as sustained-release tablets, which can be composed of