Advantages And Disadvantages Of Vesicles

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Vesicles are spherical aggregates composed by amphiphilic compounds where the lipid bilayer surrounds an aqueous void volume, which can be “loaded” with almost any variety of water soluble marker molecules. Therefore, the vesicles may contain both lipophilic and water-soluble substances. Phospholipids form vesicles being also the fundamental matrix of natural membranes and represent the environment in which many proteins and enzymes display their activity [1, 2]. Moreover, phospholipids present advantages over synthetic materials including lack of toxicity, biodegradability and biocompatibility. Consequently, vesicles are utilized as versatile carriers in the fields of medical, therapeutic and analytical applications [1-4]. Several strategies…show more content…
Béalle and collaborators (2014) described the use of superparamagnetic iron oxide nanoparticles (ɣ-Fe2O3) to decorate catanionic vesicles. The vesicles were prepared by using cetyltrimethylammonium chloride and myristic acid and the nanomaterial was synthetized in aqueous alkaline solution by co-precipitation process of FeCl2 and FeCl3. The decoration and incorporation of ɣ-Fe2O3 was carried out by an adsorptive process onto the vesicles structure [7]. Additionally, silica-coated unilamellar surfactant vesicles was prepared by hydrolysis and condensation of silicon alkoxides [8] into organized inorganic material (Dioctadecyldimethylammonium bromide and didodecyldimethylammonium…show more content…
In this synthesis, the glycerol acts as the solvent for the synthesis reaction as well as the reducing agent and as stabilizers of the AuNP. Therefore, this work describes the self-assemblage of AuNP photochemically synthetized in glycerol on vesicles structures. After the optimization of some analytical features of the AuNP synthesis (irradiation time, HAuCl4 concentration), these AuNP were immobilized onto vesicles structures composed by the phospholipid DOPC (1,2-Dioleoyl-sn-glycero-3-phosphocholine). This nanosystem was characterized by using UV-VIS spectrometry, transmission electron microscopy (TEM), dynamic light scattering (DLS) and cyclic voltammetry (CV). The results show that the vesicles were decorated with gold nanoparticle of (8 nm) with the advantage that the method is fast and reliable since no nanoparticle extraction is needed and can be used in immunoafinnity column and biosensor field.
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