Advantages Of Liposal Drug Encapsulation

Many molecules, particularly peptides and polypeptides are physically embedded in polymers to create a complex network of interconnecting pores through which the drug could subsequently diffuse. The pore structure and polymer composition is controlled in order to design systems that release the drug at nearly any rate and for nearly

Thus, I wish to focus my research in this. Besides, I am also highly interested in Localized Drug Delivery Systems. This is because, although drug administration has been a long-standing solution to alleviate illnesses, it also poses potential risks to health. Thus, if more researches are conducted to apply drugs locally instead of systemically, it can appreciably minimize their adverse effects and significantly enhance their delivery, both spatially and temporally, to combat some of the most fatal diseases of recent

route. It may be in the form of capsules, powders or tablets. There are some things that may hamper the process of absorption, such as different types of medications being used at the same time. For example, some antibiotics are not absorbed

Pharmacokinetic analysis suggests that the orally administered nanoemulsions had a higher rate of absorption and the concentration of the drug in the brain and plasma was the highest. Formulation: The drug nanoemulsion was prepared by adding 50% of the drug solution (with dehydrated ethanol) to one ml of safflower oil and it was stirred for the oil drug mixture to distribute homogenously and for all the ethanol to evaporate. Deionized distilled water (contains egg phosphatidylcholine) and deoxycholic acid.(40mg) make up the aqueous phase. Both the phases are heated at 70oc separately. The oil phase was slowly added to the aqueous phase and stirred well. The mixture was then sonicated (21% amplitude and 50%duty cycle). The mixture formed (drug containing nanoemulsion) was then filtered and stored at 4oc.Preparation of aqueous suspension was made using 3H Labeled drug and unlabeled drug in ethanol along with Deionized distilled water (contains egg phosphatidylcholine) and deoxycholic acid. The suspension was sonicated in order to lessen the particle size [2]. An example is Saquinavir (anti-HIV inhibitor) showed enhanced oral absorption and increased concentration of drug in the brain when incorporated in a nanoemulsion

Microspheres formulated using 0.1 M calcium chloride exhibited the highest drug loading at 14%, with 66.5% encapsulation efficiency. Less than 4% and 35% propranolol release occurred from hydrated and dried microspheres, respectively, in 2 hours in simulated gastric fluid (SGF). 90% of the drug load was released in increments of 5 hours and 7 hours from hydrated and dried microspheres, respectively, in simulated intestinal fluid (SIF). Prior incubation of hydrated microspheres in SGF extended the time of release in SIF to 10 hours. Restricted propranolol release in SGF and complete extraction in SIF demonstrate the potential of alginate gel microspheres for oral delivery of

"CMAX Technologies Inc. is a drug delivery company with expertise in solid oral dosages. The Company was established in 2008 with an objective to provide prompt and reliable services to the Pharmaceutical sector worldwide and to improve the product quality through technological innovations. CMAX Technologies Inc. currently provides assistance to the pharmaceutical industry in developing immediate release and once-a-day drug delivery systems from lab scale to commercial level” (CMAX Technologies Inc., 2015). They are located in Markham, Ontario and the Director is Jeff Rewick. CMAX Technologies Inc. currently provides assistance to the pharmaceutical industry in developing immediate release and once-a-day drug delivery systems from lab scale to commercial level. CMAX Technologies Inc. will be an excellent company to study for the project due to the following reasons:

In this study, published in the scientific journal Advanced Materials, Quanyin Hu has created a better way to administer doxorubicin and TRAIL, two anticancer drugs. By using platelets, part of the blood that aids in clotting, to mask the foreign drugs from the body's defense system, these bioengineers caused the drugs to stay in the body for a longer amount of time when compared to the amount of time non-platelet covered anticancer drugs stayed in the body. The results of this experiment showed that platelet covered anticancer drugs stayed in the body longer than the same anticancer drugs surrounded by a nano-gel system. In this experiment, the dependent variable was the amount of time the anticancer drugs stayed in the body of a mouse.

Chemoembolization using drug eluting microspheres (DEM TACE) was developed to prolong the release of chemotherapeutic agent within the tumor in a prolonged and slow manner. Microspheres (HepaSphere™ Microspheres) 30-60 μmare able to absorb chemotherapeutic agent (Irinotecan). After being mixed with contrast media, microspheres get larger size to 100–200 μm and slowly release the cytotoxic drug. The advantage of DEM TACE is to increase the concentration of chemotherapeutic agent within the tumor, with decreased systemic side effects and toxicity [4,5]. Additionally, the arterial supply of the tumour is embolized by the spheres like in

Sustained release Paracetamol microcapsule was prepared by surface deposition and coalescence method where Paracetamol was core material and Aqual coat acted as coating material. 100gm of Paracetamol was taken in a beaker and 22ml of Aqua coat was added to it in differential installment with proper mixing. The wet mass was air dried and passed twice through the sieve 14meshes and kept in an oven at 50℃ for 2 hours. After drying the granules were sieved through 14,18 and 20 meshes and collected in different size range.About 100ml of paraffin oil and 500mg Span 80 were mixed in a beaker with continuous stirring at 1300rpm for few minutes and made an emulsion by adding 15ml Aqua coat. The temperature was raised to about 80℃. The Aqua coat emulsion

It was proven that surface active agents which are the backbone of the formulated lipid vesicles can enhance the transdermal delivery of drugs by lowering the permeability barrier of the skin and interacting with the SC in vitro [45]. On the other hand, Studies also reported that the drug molecules to be effectively transported across the SC they must be entrapped within the lipid vesicles suggesting that the vesicles act as drug carrier systems and not as penetration enhancers [46].

Due to HPMC is a pH-independent polymer, it sustain the drug release by hydrating to form a gel layer at the surface of the tablet. Sodium alginate is a pH-dependent, when exposed to acidic in stomach; it will convert to insoluble alginic acid. By the way, the type and amount of polymer affected the release of drug. For both forms of tablets usually should be stored in tight, light-resistance container or amber glass at 15-25 oc. The shelf life is three years from the date of manufacturing. For capsule extended release oral contains 100mg, 120mg, 180mg, 200mg, 240mg, 300mg and 360mg of the active ingredient. These forms using the diffusion delivery system which are consists of controlled-release coated pellets enclosed in a hard gelatin capsule. Polymers can be using both water soluble and water-insoluble polymers. When exposed to water in GI tract, the soluble polymer will slowly dissolves, allow the drug to diffuse while the insoluble polymer act as barrier maintaining controlled release of the drug into GI tract. It should be stored in tight light-closed container at room temperature

In the first DEB that is applied for patent by Amundson et al., the drug is loaded in form of microcapsules or polymer coated microcapsules and this incorporated into the viscous matrix and applied

Oral delivery of anti-cancer drugs is a greater advancement in chemotherapy, which offers “Treatment at Home” a dream of cancer patients that improves patient compliance with reduced adverse effects. Cancer chemotherapy, mostly involves parenteral administration of anti-cancer drugs either by intravenous infusion or bolus injection, which is associated with serious side effects due to high plasma drug levels above maximum tolerable concentration (MTC) and is also less effective route due to the short exposure time of anti-cancer drugs to cancerous tissue by rapid excretion of the drug from systemic circulation [1]. In contrast, oral chemotherapy improves therapeutic efficiency by maintaining reasonable plasma drug levels, prolonged exposure time of anti-cancer drugs and avoids side effects by maintaining the drug concentration below MTC by moderate prolonged absorption from the gastrointestinal tract into systemic circulation [2]. Docetaxel is a highly effective second-generation taxane anticancer drug used in the treatment of breast cancer, ovarian cancer, non-small cell lung cancer and other tumors [3-6]. However, oral delivery of docetaxel has negligible oral bioavailability ( 99.9%). Accurately weighed sample (4 mg) was placed in a flat bottomed standard aluminium pan and scanned at a scanning speed of 10°C/min from 30○C to 300○C under a nitrogen gas flow of 80 mL/min.

Accessibility: The different sites in the oral cavity are easily accessible, which means, increase in patient convenience. Also, the correct placement of the delivery system at any site in the oral cavity allows the targeting of a specific membrane, thereby, differentiating the different oral cavity routes.

The treatment of disease with drugs involves many factors. The ability for drugs to reach the infected area is dependent on absorption, distribution, metabolism, and excretion. This ability is only made possible by transport mechanisms in barrier epithelia. Most drugs carry a positive or negative charge in the body, making them slightly polar and hydrophilic. This is important because it keeps the drugs from permeating across various membranes in the body. Due to these characteristics, our bodies need specialized transport elements to ensure the drug can do its job. The transporters allow certain charged molecules to get through barrier membranes, and are thought to be involved with detoxification and drug