Pharmacogenetics is the study of how someone’s genetics influences how well they respond to pharmacotherapy.
The Inter-Individual response to pharmacotherapy can range from no response to adverse drug reactions that can be life threatening.
Adverse Drug Reactions are currently ranked as one of the top leading causes of death in the developed world.
Adverse Drug Reactions in Response to Chemotherapy are especially common as Chemotherapy Drugs are characterized by a narrow therapeutic window, high toxicity profile and high failure rate.
Alpha Genomix is partnering with your oncologist to deliver a genetically guided treatment regimen that includes the chemotherapy drugs and dosage that is most likely to work for you based on your genetics.
Adverse drug events are estimated to cause more than 1 million emergency department visits and 125,000 hospital admissions, affecting approximately 1.9 million hospital stays each year.
Causes of hypersensitivity are unclear, but are possibly attributed to paclitaxel itself (via a non-IgE mechanism) or its excipient Cremophor EL via potential complement activation2. Premedication with dexamethasone, diphenhydramine, and a histamine h2 antagonist can reduce the incidence of such hypersensitivity reactions, but they are not entirely preventative. Boulanger et al3 reported the overall incidence of hypersensitivity reactions varied between 8-45%, where minor reactions occurred in 40% of patients and severe reactions occurred in 1.3% of patients. Such reactions predominantly occurred within the first minutes of infusion and mostly during the first or second infusion. In this study3, hypersensitivity reaction grades were determined utilizing the U.S. National Cancer Institute Grading System. In response to a hypersensitivity reaction, medications such as antihistamines, corticosteroids, epinephrine, bronchodilators, or oxygen can be used to alleviate symptoms3. After resolution of symptoms, paclitaxel can be
Joy Wisneski 1318 Ashland Greensburg, Pa. 15601 724-834-1638 University of Pittsburg at Greensburg EEOC Charge No. 533-2015-01193 Updating incidents and addition information within Pitt Greensburg. Neither the University or Jack Gaffney Business agent IUOE local 95 95A will take reasonability in regard to the bylaws in contract or the
The consumers receive the biggest lost because the use of wrong drug and doses can lead to other illness and even death.
Anti-Transcendentalism, also known as dark romanticism, was a literary movement that revolved around the negative aspects of life and human nature.Many authors have made a name for themselves through Anti-Transcendentalism, including Nathaniel Hawthorne and Edgar Allan Poe.Both writers used their stories as a platform to expose the "reality" of human nature. Hawthorne discuss' the foolishness found in youth in "Dr. Heidegger's Experiment" while Poe writes about the tragedy of not being able to escape your fate in "The Fall of the House of the Usher". So essentially, each writer effortlessly demonstrates the traits of Anti-Transcendentalism.
The side effects of medicine can be as mild as a headache or as dangerous as coma and death. A personal example
The Eastern Roman Empire, also known as Byzantine Empire, was superior to its Western partner. Christianity was the sole religion and was practiced throughout the Byzantine Empire. Trade had a dominant role on the economy of the Eastern Roman Empire. Their strong military and defensive strategies had a huge role on their longevity. The Eastern Roman Empire was more successful than its Western counterpart due to various factors including religion, economy, and longevity.
The U.S. Department of Health and Human Services (HHS) (2013) reported that U.S. prescription drugs, especially opioids analgesics, have been increasingly involved in drug overdose deaths. Unfortunately, drug overdose deaths from prescription drugs, especially opioids analgesics outnumbered deaths related to motor vehicle accidents back in 2009. Actually, in 2010 only, 16,651 deaths were connected to opioids overdose, an increase of 60 percent of overdose losses from any other drug class, prescribed or illegal. Specifically, in Florida, the attorney general of Florida (2012) stated that an average of seven Floridians die every day as a result of overdose from prescription drugs, which is five times greater than losses from the use of all illegal drugs put together.
HC1: Personalized medicine is a relatively new practice that involves using a person’s genetics to make medical decisions about which direction to take in terms of disease prevention, treatment, and diagnosis (“Personalized medicine,” 2015). The practice of personalized medicine allows doctors to predict which diseases a certain individual may be susceptible to so that proper treatment less likely to harm the patient can be ensued. This could potentially be an incredible breakthrough in the field of science and medicine (“What is personalized”, n.d.).
List one or two adverse reactions for the selected agent(s) that would cause you to change therapy.
With the growing reliance on medication therapy as the primary intervention for most illnesses, patients receiving medication interventions are exposed to potential harm as well as benefits. Medicines have proven to be very beneficial for treating illness and preventing disease. This success has resulted in a dramatic increase in medication use in recent times. Unfortunately, this increase in use and expansion of the pharmaceutical industry has also brought with it an increase in hazards, error and adverse events associated with medication use.
People all over the world, continue to be tendered prescription medication, which in many cases further complicate health issues with its myriad of side effects. In fact, statistics have shown that approximately 100,000 people around the world die as a result of prescription drugs annually (Smith, 2012). On the contrary, according
In the same country where someone dies from accidental prescription drug overdose every 19 minutes, one must ask what is being done by the FDA to stop this. The answer to this is quite simple. Nothing. In the past thirty years, approximately 90% of all the new drugs approved by the FDA have had little to no advantages over existing drugs on the
Adverse reactions to drugs are common and almost any drug can cause an adverse reaction.
With access to prescription drugs, people are able to treat a multitude of diseases and illnesses. These drugs help deal with pain, inability to sleep, depression, and much more. Every day we are increasingly living in a world where there is better living through chemicals. However, what most do not seem to see is the rising tide of pain, illness, and ultimately death being caused by the pills people take every day. Most keep drugs in a special place in their minds, where they see them as harmless. Sadly, this is not the case, and in some cases our prescription drugs can be just as harmful as illegal drugs (King 68).