Alcohol And Hepatocellular Tumor

Alcoholic fatty liver (steatosis) can lead to cirrhosis and is caused by ingestion of more than one alcoholic drink (14 grams of alcohol) per day for women and two alcoholic drinks (28 grams of alcohol) per day for men (McCance & Heuther, 2014). Intravenous drug use, unprotected sexual intercourse as well as blood transfusions can lead to the transmission of Hepatitis B and C viruses.

Cirrhosis is the 12th leading cause of death in the United States. Cirrhosis affects one of the largest organs in the body, the liver. It is a condition that slowly worsens the liver and is unable to function normally due to chronic injury. Cirrhosis consists of four stages with the fourth stage being the most advanced stage of cirrhosis. When healthy liver cells are damaged and replaced by scar tissue (fibrosis) it’s known as a degenerative disease called cirrhosis. Chronic alcoholism is the leading cause of cirrhosis due to excessive drinking of alcohol, which causes the liver to swell. In sequence with alcoholism and hepatitis C, or alone obesity can be a risk factor in developing cirrhosis. Cirrhosis of the liver is a disease that can affect many individuals if the condition is not caught in early stages it can become deadly.

Cirrhosis is known as a chronic disease of the liver. Cirrhosis usually develops when the scar tissue replaces normal, healthy tissue in the liver. It tends to happen whenever healthy cells are damaged over a long amount of time, usually for many years. However, the scar tissue makes the liver lumpy and hard, after a while, the organs will start to fail and the scar tissue makes it tough for the blood to get through a large vein (the portal vein) that goes into the liver. Occasionally when the blood backs up into the portal vein, it can get into the spleen (an abdominal organ involved in the production and removal of blood cells) and can really cause trouble. What causes this is other liver conditions or diseases the person may already have, which includes an (alcohol-related liver disease) by drinking too much alcohol for many years non-stop. It causes fat and inflammation in the liver. The amount of alcohol that it takes to hurt the liver is different for everyone.

Liver cirrhosis is a life threatening disease and is irreversible. It is therefore of utmost

About 50% of Americans actually have liver disease but most symptoms are very dull and unnoticeable that people do pay attention or not aware of them. The most common symptoms for severe liver disease include prominent yellowing of skin and eyes, very dark tinted urine, light colored stool or bowel movements, mental confusion and continued possession of liquids in abdominal area. The 50% of American mentioned previously have a slight liver disease due to drinking an excessive amount. There are simple guidelines to follow that differ from man to female when it comes to drinking. Males can handle alcohol more efficiently than women. Not only does alcohol ruin the liver many over the counter drugs do like Tylenol. Take in mind the liver is the bodies filter everything that comes in it must go through the liver so it is safe for the consumer. A liver can only handle so much at one time that is why people become intoxicated due to the fact that they do not give their liver enough time to process all the alcohol. In doing this the liver gets severely damaged, although the liver the magical organ can regenerate itself people tend to drink like alcoholics and that is when liver disease because an issue. Indeed there must be about 75% damage to the liver to start experiencing failure in bodily functions. On occasion liver failure is reversible if not all cells are damaged but if so then the

Alcohol is toxic and disrupt's the body's ability to regulate blood glucose. When alcohol enters the body it is absorbed into the bloodstream by the stomach and small intestines, and is then circulated throughout the body. Although the alcohol in the blood can be metabolised in different ways, at different parts of the body, it primarily takes place in the liver. Alcohol is converted to acetaldehyde by the enzyme alcohol dehydrogenase, and acetaldehyde is converted to acetate by aldehyde dehydrogenase.  These metabolic reactions require the coenzyme NAD+ in order to occur. The acetate product can be used by three different pathways. One of these is more significant to the regulation of BGL, and involves biosynthetic reactions which convert

Ingestion of more than 50 –70 g/day of alcohol for prolonged periods is defined as heavy alcohol intake, which is a well- known HCC risk factor. The link between the amount of alcohol intake and the risk of HCC is still unclear. Although heavy intake is associated strongly with the development of cirrhosis, there is little evidence of a direct carcinogenic effect of alcohol otherwise. But it was found that there is a synergistic effect of heavy alcohol ingestion with HCV or HBV which are operating together to increase HCC risk by more actively promoting cirrhosis. In a study it was reported that HCC risk increased in a linear fashion with daily intake of more than 60 g. But with the concomitant presence of HCV infection, there was a 2-fold

Alcohol can have negative effects on liver function. When alcohol is consumed the body starts trying to metabolize it but has no way of doing so. The liver then has to work detoxify and remove the alcohol from the bloodstream. Once the liver finishes the oxidation process, the alcohol becomes water and carbon dioxide. If the alcohol accumulates in the body, it may destroy cells and organs. The oxidative metabolism prevents this from happening. When too much alcohol is ingested at once, the toxins take a toll on the body, starting with the liver. The oxidative metabolism of the alcohol creates molecules that lead to a condition called fatty liver. Research supports that fatty liver, the early stage of alcoholic liver disease, develops in nearly

A few of those causes include Hepatitis C, Nonalcoholic steatohepatitis , and certain genetic diseases. Perhaps the most common cause is chronic alcohol abuse. According to the National Institute of Alcohol Abuse and Alcoholism “About 10 percent to 15 percent of people with alcoholism develop cirrhosis, but may survive it. Many are unaware that they have it, and about 30 percent to 40 percent of cirrhosis cases are discovered at autopsy (Anand 1999).”

• Cancer. Cancer that either begins in or spreads to liver (eg. Breast, lung, blood or lymph node cancer) can cause liver to

Over time the liver is unable to metabolize the alcohol and leads the liver to form fibrous tissue, develop nodules, and the liver shrinks and has a nodular uneven appearance (Pearson, 2015). Biliary cirrhosis is another type of liver disease that is characterized by the inability of bile to be excreted, causing build up within the liver which eventually destroys the cells within the liver. The third type of cirrhosis is known as posthepatic cirrhosis and is the result of a patient having hepatitis B or C resulting from an unknown cause. This type of cirrhosis causes the liver to shrink and become nodular and fibrous resulting in destruction of the liver cells. Risk factors for all three types of cirrhosis include high risk behaviors such as consuming excessive amounts of alcohol, drug use (primarily IV), unsafe sexual behaviors leading to the development of hepatitis B or C. Clinical manifestations of cirrhosis include portal hypertension, which is caused by the portal vein becoming inflamed and casing blood to be rerouted to adjoining lower pressure vessels, splenomegaly, ascites which is the enlargement of the stomach due to a collection of fluid in the abdominal cavity, esophageal varices, which are enlarged, thin walled veins that form in the esophagus, portal, systemic encephalopathy, which is due to neurotoxins being rerouted into the blood, hepatorenal syndrome caused by imbalanced blood flow, and spontaneous bacterial peritonitis, which is a contamination of the peritoneal cavity (Pearson,

Alcohol is a dangerous substance that deteriorates the human body if consumed on a regular basis. Even if a person is not a heavy drinker, their body still go through changes when they drink alcohol (NIH, 2010). Alcoholic beverages are an extremely toxic substance that affects one physical wellness. The National Institute on Alcohol Abuse and Alcoholism known as NIH, discusses how alcoholic beverages affects a person’s brain, heart, and liver. Also, the NIH explains how alcohol abuse can lead to cancer in the mouth, esophagus, breast, liver, pharynx, and larynx. It has been noted that alcohol abuse can cause the immune system of a person to weaken (NIH, 2010). Various research has been conducted in order to determine which parts of the brain is impacted because of alcohol consumption (NIH, 2010).

Alcoholism was the commonest cause of cirrhosis 51 (72.85%), with incidence of chronic hepatitis B being 5(7.14%). 13 patients had cirrhosis of unknown etiology. This finding was different from that of Maric et al 10 where 43% had chronic hepatitis B infection

"Many alcoholics exhibit swollen and tender livers. The prolonged use of large amounts of alcoholism without adequate diet may cause serious liver damage, such as

One of the main organs that gets affected is the liver. The liver is essential when it comes to the food we digest, the absorption of nutrients, controls infections, and it helps get rid of the toxins in the body. There are over 2 million people who suffer from liver disease all which is contracted from the large quantities of alcohol. Heavy drinking takes a humongous toll on the liver. It can lead to a variety of problems and the liver inflammations such as Steatosis or Fatty liver disease (when your liver gets fat, and can reversed with lifestyle modifications.). Alcoholic hepatitis (swelling of the liver, causes many other risks, and there is only one-way to stop it, which is to stop drinking alcohol period.). Fibrosis (An alcoholic liver disease, term that encompasses the liver manifestations of alcohol overconsumption.), and Cirrhosis (a late stage of scarring of the liver, result of the liver disease and other conditions.). If scar tissue keeps blood from flowing through the liver, the blood cannot filter, leaving many toxins and waste to build up in the body. This can lead to confusion, agitation, tremors, and sometimes comas. Once scaring has progressed, nothing can repair the liver or to cure