Alzheimer 's Disease ( Ad )

Alzheimer disease (AD) is the most common cause of dementia in the elderly, accounting for 65–70% of all cases (Jellinger, Janetzky, Attems, & Kienzl, 2008). The other dementias are of the Parkinson 's group, the fronto-temporal group and the vascular group. The total worldwide yearly costs for the treatment and care of patients suffering from dementia are estimated to be around 250 billion US dollars. The lifetime risk for AD between the ages of 65 and 100 is 33% for men and 45% for women with an annual increase of 1–2% in the seventh decade to almost 60% in the 10th decade with doubling every 5 years (Jellinger et al., 2008). AD is incurable, and thus represents a major public health problem. AD represents a challenge to humanity due to its relatively recent discovery, progressive nature of the illness, and complex diagnosis.

Alzheimer’s Disease is a progressive neurological disease; it often attacks the brain tissues causing memory loss of one’s identity and regular behaviors. Statistics indicates that the rate of predicted people to get Alzheimer’s will increase briskly as time goes on. There are currently no cures for such disastrous disease, but there are currently approved treatments available that can help people within the early stages of Alzheimer’s. Once the disease is too far along, deteriorated brain cells are nearly impossible to revived or regenerate without stem cells, which have not been successfully ascertain. Research and medical trials are being conducted all over the world hoping to find the starting cause of it in

Alzheimer 's disease (AD) is a progressive degenerative disease of the brain from which there is no recovery. There are three brain abnormalities that are the hallmarks of the Alzheimer’s disease is initially caused by plaques buildup in the brain’s neurons as illustrated in figure 1. The support structure that allows the flow of the nutrients through the neurons gets damaged and ultimately there is loss of connection among the neurons and they die off (National Institute of Health, 2015). This causes the brain tissue to shrinks, which is called atrophies. All this ultimately lead the victim of this disease to face difficulties in governing emotions, recognize errors and patterns, coordinate movement, and remember. Ultimately, a person with AD loses all memory and mental functioning.

The FDA recently has allowed two treatments to be used for Alzheimer patients. One of the treatments is a Partial Glutamate Antagonist, which is an important transmitter to the brain. It is said that Glutamate helps patients more than sugar pills do, however; it is said that too much

Alzheimer’s disease is a prominent brain disease that effects a massive amount of individuals in the United States. Alzheimer’s disease (AD) is the sixth leading cause of death in the United States, accounting for 60-80% of dementia cases, with no chance of being cured, prevented or decelerating over time (Alzheimer’s Association, 2014). AD is the most well-known form of dementia, causing complications in brain function in the areas of memory, thinking, and behavior (Alzheimer’s Association, 2014). In an effort to gain a deeper understanding of Alzheimer’s disease, researchers create new knowledge about the disease, which is then distributed to the public. The goal in this information disbursement is to find new and inventive ways to treat AD, prevent AD from progressing at such a rapid pace, and aid in the quality of life in those diagnosed with AD as well as caregivers and medical professionals providing treatment to individuals’ with AD.

Factors that are not preventable include family history, heredity, and age. Risks for eFAD include head trauma, and head to head connections. To help cope with the deteriorating disease, it is important for a nutritious diet as well as physical activity, social engagement, and mentally stimulating activities. Healthy diet helps ensure a healthy brain and heart which helps protect the body. Regular exercise is also important, this increases oxygen and blood flow which benefits cardiovascular system. Treatment for eFAD includes helping to maintain mental function and manage behavioral system. Medications that are used to comfort systems include Donepezil, Rivastigmine, and Galantamine used to treat mild to moderate Alzheimer’s. Targets for future drugs include Beta Amyloid (main components for plaque), and Tau proteins (main component in tangles.) Other hopes for drugs and therapies include the targeting of the overall inflammatory response as well as therapies to target specific areas of genetic, molecular, and cellular

This study will investigate and test how some medications can smooth the progressive advance of the Alzheimer in patients with more than 70 years. Alzheimer which is a degenerative disease of the neuro system due to memory loss is still being very questionable and debated. As of today there is no cure, nor reversal for the disease. Many researchers are still studding and looking for therapies and medication that can stop or reverse the development of the disease. It is very important to prove that some medications can help to cope with the disease. In my study I will be able to demonstrate

Research indicates that cases of Alzheimer’s disease involve “…damage to improper function of on or more of these brain areas…: the prefrontal lobes, the hippocampus, amygdala, and diencephalon (van der Flier et al., 2005; Caine et al., 2001). Researchers have also identified biochemical changes that occur n cells as memories form; studies suggest that acetylcholine and glutamate are in low supply or at lease function differently, in the brains of Alzheimer’s victims (Chin et. al.., 2007; Akairke,

As a disease resulting in the loss of high cognitive functions, the Alzheimer’s disease affects brain cells and the nervous system of the body. A better understanding of the neurotransmitter, drug use to treat the disorder, and the possible side effects will bring reasoning to the possible actions of a person with the disease.

Alzheimer’s disease is the 6th leading cause of death in the United States (Help End Alzheimer's.). It is a common form of dementia categorized by a progressive decline in cognitive function (Simmons-Stern, 2010). According to the Alzheimer’s Association, “More than 500,000 seniors die each year because they have Alzheimer's disease”. Therefore Alzheimer’s disease kills more people than prostate and breast cancer together (Help End Alzheimer's.) Although there is no cure or treatment to slow the progression of Alzheimer's disease it can be treated with medication, memory activities, and music therapy. The main classification of medication that is used for Alzheimer disease is Cholinesterase inhibitors. A noninvasive and inexpensive

The only drugs currently approved for AD are cholinesterase inhibitors such as ( Galantamine- Rivastigmine-Donepezil) and its mechanism to increase the Acetylcholine in the brain and mainly used in mild to moderate Alzheimer’s and the

There are also exercises for the brain to prolong the progression of Alzheimer’s. “Really, any kind of word or number puzzles work here. The point is to continuously stimulate the brain and keep your recall abilities high.” “By rotating through the different activities, you’ll stimulate different areas of the brain. This, in turn, helps keep the nerves functioning and healthy.” (15 Best Brain Exercises to Prevent Alzheimer’s and Dementia, 2018, p.1) It is very important to stimulate brain cells and keep them active. This, in turn, keeps brain neurons firing and active. There is a new breakthrough medication that helps to slow down the process of Alzheimer’s. “NAMZARIC is the FIRST AND ONLY once-a-day capsule that works on two pathways in the brain to fight the symptoms of moderate to severe Alzheimer’s disease (AD)” (NAMZARIC, 2017, p.1) “Donepezil HCl, is thought to work by slowing the breakdown of a chemical in the brain called acetylcholine. This chemical is involved in learning and memory.” (NAMZARIC, 2017, p.1) “Memantine HCI, may help regulate the abnormal activity of glutamate—another chemical in the brain that is important for learning and memory.”(NAMZARIC, 2017, p.1) NAMZARIC is a new medicine and breakthrough for the cure of Alzheimer’s. The capsil works in two ways with two drugs involved. Acetylcholinesterase which

Alzheimer's Disease is a condition that affects 50% of the population over the age of eighty five, which equals four million Americans each year. It is becoming an important and high-profile issue in today's society for everyone. There are rapid advancements being made in the fight against this disease now more than ever, and the purpose of this essay is to educate the public on the background as well as the new discoveries. There are many new drugs that are being tested and studied every day which slow down, and may even halt the progress of the disease.

A disease that sweeps across the nation and affects nearly 80% of the population ages 60 and up is known as Alzheimer’s. A misconception that many people believe about Alzheimer’s is that it is a part of getting older. It is not true. Alzheimer’s is an intricate neurodegenerative disorder associated with “protein misfolding and aggregation, oxidative stress, mitochondrial abnormalities and neuroinflammatory process at a molecular level” and “synaptic loss, cholinergic dysfunction, and abnormal protein depositions in the brain”. Some symptoms associated with this disease are delusion, inability to recall or retain information, mental decline, aggression, personality changes, mood swings, and etc. Though there are currently no cures for Alzheimer’s, cholinesterase inhibitors such as donepezil, galantamine, rivastigmine and NMDA receptor antagonist memantine are used as pharmacotherapy treatment to slow down the progression and temporarily alleviate symptoms. This essay is primarily focused on Donepezil and the cognitive alleviation it results in for patients with Alzheimer’s. The first part of the paper will summarize two preclinical and two clinical trials done on Donepezil to subjects with Alzheimer’s or Alzheimers like symptoms. The second part will describe the implications and future directions from all the results obtained.

This supplement can improve reminiscence formation and do not forget, enhance getting to know capability, increase interest span and even improve temper. Galantamine is recommended to treat vascular dementia and it is able to treat that disease. Galantamine may be used on its personal or blended with choline supplements for increased results. Extra benefits of this supplement relate to how it can improve or affect sleep styles. Taking a Galantamine dose later in the day is tested to assist a man or woman in falling asleep greater fast and improving sleep pleasant. Galantamine has additionally been determined to increase dreaming interest which could have a high-quality effect on reminiscence retention. Other humans use this supplement to promote a kingdom of lucid dreaming. On this nation, a person can be conscious that they may be dream and feature the ability to control the dream at the same time as they're experiencing it. Sometimes, this situation also can result in an out-of-body revel in and its miles effective for wonderful visualization techniques. When the degrees of Acetylcholine inside the mind are improved, this may decorate brain characteristic in several specific regions. This crucial chemical partakes in a number of cognitive strategies like memory formation, the potential to maintain attention, and our potential to suppose and learn. On this respect, Galantamine could be very just like supplements like Huperzine A which is also an acetyl cholinesterase