Alzheimer's Disease And Memory Analysis

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

Alzheimer's disease is one of the most common causes of dementia. The term 'dementia' describes a set of symptoms, which can include memory loss, changes in mood and problems with communication and reasoning. These symptoms occur when certain diseases and conditions, including Alzheimer’s disease, damage the brain. Alzheimer's disease could be described as a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop

Alzheimer's disease, first described by the German neurologist Alois Alzheimer, is a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop in the structure of the brain, leading to the death of brain cells. People

Later in the course of the disorder, affected individuals may become confused or disoriented about what month or year it is, be unable to describe accurately where they live, or be unable to name a place being visited. Eventually, patients may wander, be unable to engage in conversation, erratic in mood, uncooperative, and lose bladder and bowel control. In late stages of the disease, persons may become totally incapable of caring for themselves. Death can then follow, perhaps from pneumonia or some other problem that occurs in severely deteriorated states of health. Those who develop the disorder later in life more often die from other illnesses (such as heart disease) rather than as a consequence of Alzheimer's disease

Early 1900’s a man named Alois Alzheimer cared for a woman who had rapid severe declining dementia, after she died he was able to study her brain where he found atrophy of the grey matter along with plaques and neurofibrillary tangles, which when destroyed interrupts the messages sent from the neurotransmitters to the central and limbic regions of the brain resulting in early

years after onset of symptoms…and typically die from bronchitis or pneumonia” (Cummings and Cole 2).

Alzheimer’s: Scientists know that during Alzheimer’s two abnormal proteins build in the brain. They form clumps called either ‘plaques’ or ‘tangles’. These plaques and tangles interfere with how brain cells work and communicate with each other. The plaques are usually first seen in the area of the brain that makes new memories. A lot of research is focused on finding ways to stop these proteins in their tracks and protect brain cells from harm.

Even today, after so much study, Alzheimer’s is not fully understood. However, researchers do agree that this degenerative disease is caused by the gradual buildup of fibrous protein compounds in the brain, which are known in the scientific world as amyloids. These amyloids in the brain area act like plaque and as a result of their presence, the normal brain functioning is disrupted.

Alzheimer’s disease is a psychological disorder that primarily affects the temporal lobe of the brain which focuses on memory, but also the frontal and parietal lobes which focus on behavior, intelligence, and language. The instant an individual has Alzheimer’s or Dementia there is a constant cycle of decay on the brain from the beginning to the end of the disorder (basically until death). This disorder eats away at the patients brain slowly and painfully until death which is why the American Pyshcological Association says that “The time between diagnosis and death typically ranges from seven to 10 years.” (APA 2016)

Alzheimer 's disease is an ongoing condition that destroys the connection of cells in the brain. According to the Alzheimer’s Foundation of America (AFA), it is estimated that as many as 5.1 million Americans have Alzheimer 's disease today. Alzheimer 's disease was discovered by a German physician named Alois Alzheimer. In 1906, Dr. Alzheimer saw changes in the brain tissue of a woman who died from what he presumed to be a mental illness. He described her symptoms as memory loss, language complications, and unpredictable actions. After she died, he examined her brain to further understand how she died. He discovered distinctive plaques and neurofibrillary tangles in her brain tissue.

Many have lost loved ones to Alzheimer's including Alan Holbrook. Alan Holbrook is losing the women he has been married to for 29 years, the mother of his children to Alzheimer's. She doesn't even know him when he comes to visit her. She has forgot his name and what he looks like. His 25 year old daughter has been his rock, she has been the one that he is leaning on during this.One of the problems with dementia, like Alzheimer's, is that you simple don't have any kind of frame of reference for what's going to happen next. Financing and paying for care for somebody with Alzheimer's disease who's going to be in a skilled nursing center is a huge issue. Alan had suddenly came to realize that with the cost of her care with the nursing home,

Alzheimer 's disease is a severe illness that affects the brain and leads to gradual memory loss, reduced intellectual ability and deterioration function of thinking. Alzheimer 's disease (AD), the most common type of dementia, is a progressive neurological disorder that increasingly robs individuals of cognitive, behavioral, and functional skills (Demakis, 2007). The reason for the appearance this disease is a collection of disorders in the brain due to which its cells are dying partially. In the case of the early stage of Alzheimer disease when the disease is not carried out the appropriate treatment mental functions are destroyed completely. The disease is diagnosed mainly in elderly people. The symptoms of Alzheimer 's disease, were first isolated by German psychiatrist Alois Alzheimer, is one of the most common forms of dementia. “As is well known, Alzheimer first described the disease that would eventually be named for him at a meeting of the South West German Psychiatrists in Tubingen in 1906. It was a brief report of the case of a 51year old woman who developed progressive dementia, accompanied by focal signs, hallucinations and delusions. On post-mortem, her brain was found to contain numerous senile plaques and a newly observed pathological structure – densely twisted bundles of neurofibrils, or neurofibrillary tangles, which were made visible to microscopic observation through a newly developed silver-staining technique.” (Perry, G. et. all, 2006). Typically, the

The research into Alzheimer's Disease has come a long way since 1906 when it is was discovered by Alois Alzheimer. He detected microscopic brain tissue changes called senile and neuritic plaques in deceased patients. These are chemical deposits consisting of protein molecules called Amyloid Precursor Protein(APP) that are fundamental components of a normal brain. However in the brain of an Alzheimer patient, an enzyme cuts the APP apart and leaves fragments in the brain tissue. These combined with degenerating nerve cells cause the plaques or lesions. These lesions are found in many sections of the brain including the hippocampus which regulates emotion and memory, the basal forebrain, and especially the basal nucleus of Meynert and the cortex, where the memory function is located.(2) Another sign of a diseased brain are neurofibrillary tangles, which are malformations within nerve cells.

The evidence has shown that the knowledge on the subject of Alzheimer's disease has progressed far from thinking that it is just a loss of memory. This disease produces a big dementia in patients, affecting millions of people and their families. These people and their families care for special needs.

In 1901 Auguste D was admitted to a mental institution because of the effects that the alzheimer's had on mind/ brain, Auguste D was studied for five years by Dr. Alzheimer before her death in 1906 Alzheimer's disease can take over your memory and cause a traumatic amount of memory loss and Can take over other functions in your body. Alzheimer's is caused by dead brain, but after Auguste death Dr. Alzheimer did an autopsy on he found unusual characteristics such as fiber tangles and what is known today as “amyloid plaques”. And he also had found that there was much shrinkage in and around her nerve cells in her brain. Then in 1931 max knoll and ernst ruska invented the electron microscope that allowed them to study brain cells even better that before. And then in in 1968 Cognitive measurement scales are created which allows researchers to measure impairment and estimate the volume of damaged brain tissue. Finally in 1974 the national institute on aging which now supports alzheimer's disease.