Alzheimer's Neuropathology

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

Alzheimer’s disease (AD), a form of degenerative, fatal dementia, is characterized by progressive cognitive decline. While AD is the most common form of dementia, its prevalence has only recently been recognized. When Alois Alzheimer first described the sequence of changes in 1907, physicians believed the disease to be an extremely rare, mid-life condition. It wasn’t until the 1970’s that the same types of changes were shown to occur in both late- and early-onset forms (Cavanaugh et.al. 2008). As such, almost all knowledge of AD has been learned within the past several decades, with new discoveries being reported almost daily. It is now estimated that Alzheimer’s accounts for as many as 60% of all dementias and affects more than 500,000

Alzheimer’s disease is a common problem in today’s society and within the older population this disease makes up the largest form of dementia. Although it is a problem in mainly older people, this disease can still occur in the younger population also. People in their 30s-50s can be diagnosed with this disease, even though it is not as common as people in their 60s-90s. The number of people with Alzheimer’s in the U.S. is close to five million and is expected to double within the next 30 years. With our modern medicine and advancements one would think a cure would be available, however, getting to the cause of the disease is a major factor. The cause of Alzheimer’s disease is one that is very debatable and questionable and most likely is a result of multiple factors rather than one. The main issue with finding the cause is because this disease affects the brain and can

Alzheimer’s disease is the most common type of dementia that generally initiates the lost memory, problem of critical thinking and behavior problems for the elderly patients. It’s not a normal part of aging but the large number of elderly people reached 65 and older are at risk of developing Alzheimer’s disease. The most common early symptoms are struggle in remembering recent events or short term memory. As the disease advance more symptoms begin to show up like problems in speaking and language, disorientation like getting lost and cease to remember the present activity that they are supposed to do. Mood swings go from happy to sad for no reason. Not managing their self, personal hygiene

Alzheimer’s disease is incurable, but there are many stages, warning signs, and risk factors that can serve as detection devices for those who have older adults in their lives. One of the most common early signs of this form of dementia is memory loss. While it is normal for people to occasionally forget things, such as appointments and names, people with Alzheimer’s tend to forget these things more often and are not able to recall them even after a period of time. Other signs that signify a possible case of Alzheimer’s is difficulty performing familiar tasks (cooking, brushing teeth), problems with language (using odd words, failing to remember correct words), disorientation (forgetting where one lives, not knowing how he got to a certain place), problems with abstract thinking (forgetting what numbers represent), misplacing items (putting a hair brush in the freezer), moodiness, personality changes (confusion, suspicion, fearfulness), and loss of initiative

Certain qualities are consistently observed in the Alzheimer’s victim. These dysfunction’s, though, are not exclusive to Alzheimer’s disease. Consequently, declaring Alzheimer’s by these parameters is a matter of degree rather than an absolute. Characteristic dysfunction’s have been noted in Alzheimer’s victims, but the degree and severity of these varies from patient to patient. Thus, evaluation of the patient’s mental status must be made based on the sum, rather than a single characteristic. Memory is one of the first noticed deficiencies, beginning typically with the recent and short term memory, and progressing from there as the disease grows more severe. In addition, deterioration in language skills, attention span, praxis (performance of an action), and visuospatial skills are commonly seen. Also observed are changes in the actions and personality of the Alzheimer’s victim. These include changes in mood, motor activities, activities of daily living, socialization skills, psychotic disturbances, vegetative symptomology, and rise in anxiety levels. Again, the

The disease stem cells could fix is called Alzheimer’s Disease (AD). The reason I chose this topic is because I have seen first hand how badly someone who suffers from Alzheimer’s Disease is affected in their daily lives. This disease completely takes over their lives and they turn into a completely different person who can hardly function. AD is very tough on the loved ones of the person suffering from it because that person, most of the time has no idea what is going on or who their loved ones are. The memories for people with AD is completely gone and even the simplest tasks such as remembering to use the bathroom becomes difficult. The way stem cells could be feasible is because stem cell-based therapies could potentially treat

On November 26th 1901, Alois Alzheimer, an assistant physician at the psychiatric institution in Frankfurt met Auguste D, aged 51 (Berrios , 2004). After talking to her and carrying out the preliminary diagnostics, the physicist realized during talking to her that his patient was giving different answers to the same questions. She also often stopped mid-sentence as if she had forgotten what she was going to say. She seemed confused and anxious. When she died, Alzheimer received her brain for analysis. When he was inspecting the brain, he came to notice the neurons had thick, strongly staining fibrils. Moreover, the cortex was full of plaques of unknown composition. Auguste D’s brain

Alzheimer's disease is one of the most common causes of dementia. The term 'dementia' describes a set of symptoms, which can include memory loss, changes in mood and problems with communication and reasoning. These symptoms occur when certain diseases and conditions, including Alzheimer’s disease, damage the brain. Alzheimer's disease could be described as a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop

“There is one thing Alzheimer 's cannot take away, and that is love. Love is not a memory - it 's a feeling that resides in your heart and soul.” (Fade to Blank). The human brain is a remarkably complex organ that processes, stores, and recalls information. “Alzheimer 's disease (AD) is a slowly progressive disease of the brain that is characterized by impairment of memory and eventually by disturbances in reasoning, planning, language, and perception. Many scientists believe that Alzheimer 's disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain that leads to nerve cell death.” (Crystal). It is the most common form of dementia, accounting for 50 to 80 percent of dementia cases, and currently has no cure. (# 3) Research continues to be done to develop better ways to care for those affected with the disease, as well as to find support for family members, friends, and caregivers. Alzheimer’s is a devastating illness that is not a normal part of aging. In order to find a cure, awareness needs to increase to improve understanding, develop effective treatments, and to essentially prevent the disease.

Early 1900’s a man named Alois Alzheimer cared for a woman who had rapid severe declining dementia, after she died he was able to study her brain where he found atrophy of the grey matter along with plaques and neurofibrillary tangles, which when destroyed interrupts the messages sent from the neurotransmitters to the central and limbic regions of the brain resulting in early

Alzheimer’s disease slowly steals a person’s dignity and erases precious memories. The “Alzheimer’s Disease Guide”, found on WebMD explains that tasks become more difficult to do often leading to confusion and behavior changes. The article further explains the progression of the disease also brings hardship to family and friends (1). To best cope with Alzheimer’s we must better understand the disease.

The research into Alzheimer's Disease has come a long way since 1906 when it is was discovered by Alois Alzheimer. He detected microscopic brain tissue changes called senile and neuritic plaques in deceased patients. These are chemical deposits consisting of protein molecules called Amyloid Precursor Protein(APP) that are fundamental components of a normal brain. However in the brain of an Alzheimer patient, an enzyme cuts the APP apart and leaves fragments in the brain tissue. These combined with degenerating nerve cells cause the plaques or lesions. These lesions are found in many sections of the brain including the hippocampus which regulates emotion and memory, the basal forebrain, and especially the basal nucleus of Meynert and the cortex, where the memory function is located.(2) Another sign of a diseased brain are neurofibrillary tangles, which are malformations within nerve cells.

In 1906 a physician, named Alois Alzheimer, cared for a fifty-one year old patient with severe dementia. Upon her death, he was able to examine her brain at autopsy. Dr. Alzheimer was able to take advantage of recent innovations in microscopy and histological techniques that allowed him to study in detail the cellular components in nervous tissue. He found that the brain of his patient had severe cortical atrophy and described the neurofibrillary bundles and plaques that are now the hallmark for definitive diagnosis of what he at that time called “presenile dementia”. An account of his first patient was published in 1907. It is a little ironic that reevaluation this case has lead some to believe that this first patient did not suffer from the Alzheimer’s disease at all. Instead they believe she suffered from a different, rare disease called metachromatic leukodystrophy (Izenberg, 2000).

principally the affiliation areas and the average worldly projection; cortical neuritic plaques – Nps, and Neurofribrillary tangles – Nfts (Goetz, 2007). Nps and Nfts are the trademark pathologies utilized to diagnose the infection. It is not yet known whether they create autonomously or they impart the obsessive methodology, since at post-mortem examination both Nps and Nfts can be found. It is accepted that plaques happen to start with, and tangles come later (The Alzheimer's Project, 2009). The neuritic or feeble plaques have a β-amyloid protein center and dystrophic neurites. The β-amyloid protein is sticky and hard to break down. This protein exists in neurons basically at neural